不同肥胖亚型血清肿瘤坏死因子α、C反应蛋白水平的变化及意义

目的通过观察不同肥胖代谢亚型患者血清肿瘤坏死因子α(Tumor necrosis factor-αTNF-α)、C反应蛋白(C-reactive protein CRP)水平,探讨血清TNF-α、CRP的变化在不同肥胖代谢亚型发病中的作用及意义。方法 选择2016年09月-2016年11月在石河子大学第一附属医院就诊的201名成年人,获得腰臀比(WHR)、体脂指数(BMI)、收缩压(SBP)、舒张压(DBP),检测空腹血糖(FBG)、餐后血糖(PBG)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋(LDL-C)、高密度脂蛋白(HDL-C)、糖化血红蛋白(Hb A1C)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿素氮(BUN),将研究对象分为正常体重代谢正常(MHNW)组、正常体重代谢异常(MONW)组、代谢正常性肥胖(MHO)组、代谢异常性肥胖(MAO)组。使用酶联免疫吸附测定的方法检测血清TNF-α和CRP的浓度。结果 1.各组Hb A1C、FBG、PBG、TG比较,MONW组、MAO组高于MHNW组和MHO组(Plt;0.001);各组ALT比较,MAO组高于MHNW组和MONW组(Plt;0.05);各组AST比较,MAO组高于MHNW组、MHO组和MONW组(Plt;0.05)。2.各组血清TNF-α、CRP水平比较,MHO组、MONW组、MAO组高于MHNW组(Plt;0.001),MAO组TNF-α、CRP高于MHNW组、MHO组(lt;0.001)。3.血清TNF-α、CRP水平与BMI、WHR、SBP、DBP、Hb A1c、FBG、PBG、TG、ALT呈正相关,与HDL-C呈负相关(Plt;0.001)。BMI、FBG、HDL-C为TNF-α的影响因素(Plt;0.001);BMI、PBG、HDL-C为CRP的影响因素(Plt;0.001)。结论MHO组、MONW组、MAO组人群体内均存在炎症状态,以MAO组最为明显;TNF-α、CRP可能参与了不同肥胖亚型的发病过程。     

SUMO-1在ApoE -/一小鼠PM2.、暴露中调控血管HIF-1a/VEGF信号通路的研究

以气管滴注方法研究了ApoE-/一小鼠经PM2.5暴露后，其主动脉弓中SUMO-1, HIF- la、血管内皮生长因子(VEGF)表达变化规律及HIF- la的SUMO化修饰情况.实验结果显示:PM2.5暴露后，小鼠主动脉SUMO-1,HIF-la,VEGF的表达上调;PM2.5暴露诱导了SUMO-1对HIF- la的SUMO化修饰;低氧条件下SUMO-1敲低导致HIF-la表达的下调结果提示PM2.5暴露通过上调细胞中SUMO-1的表达，稳定或者上调HIF- la的表达，进而影响血管内皮生长因子(VEGF)的表达，造成动脉粥样硬化斑块的不稳定.     

协同过滤中一种项目综合相似度计算方法

协同过滤算法作为一种成功的个性化推荐技术已经被应用到很多领域,但是由于协同过滤算法所使用的用户-项目评分矩阵一般都非常稀疏,导致该算法推荐效果一直较差。文章在考虑了用户相似喜好、项目平均得分的差异性和方差等因素基础上,提出了一种项目间综合相似度计算方法JAV Weighted Model,通过在MovieLens数据集上的实验表明本文方法在预测精度上与已有方法相比有一定的提高。     

基于样本重要性原理的KNN文本分类算法

KNN是重要数据挖掘算法之一,具有良好的文本分类性能.传统的KNN方法对所有样本权重看作相同,而忽略了不同样本对于分类贡献的不同.为了解决该个问题,提出了一种样本重要性原理,并在此基础上构造KNN分类器.应用随机游走算法识别类边界点,并计算出每个样本点的边界值,生成每个样本点的重要性得分,将样本重要性与KNN方法融合形成一种新的分类模型——SI-KNN.在中英文文本语料上的实验表明:改进的SI-KNN分类模型相比于传统的KNN方法有一定的提高.     

全局性N元F-强混沌系统的一个判据

设(X,f)是一个动力系统，其中X是一个含至少2个点的完备度量空间，f是X上的一个连续自映射对给定的Furstenberg族下与整数N》2，将升混沌推广到N元升混沌为此，对于X的2个非空子集A,B，借助集对(A,B)的升往复点来引入升攀援串的概念，进而定义N元升混沌以及讨论N元升混沌的一些性质最后以Furstenberg族理论为主要工具，给出一个动力系统是全局性N元多二强混沌的一个判据，并通过例子来阐述它在动力系统中的应用     

Evaluating the reliability of microsatellite genotyping from low-quality DNA templates with a polynomial distribution model

Molecular studies using trace DNA, such as from museum specimens, ancient or forensic samples and samples obtained noninvasively, often have a common problem of low quality of DNA templates. Amplification errors, such as allelic dropout and false allele, may arise during polymerase chain reaction (PCR) using such samples. A mathematical model which treats homozygotes and heterozygotes discriminately has been developed to measure sample quality and compute the confidence level of using multipletube approaches. We use plucked hair samples collected from 26 individual Sichuan snub-nosed monkeys (Rhinopithecus roxel- lana) to test the model. In this case, a confidence level of 99% can be achieved by three positive PCRs. If the sample quality is very poor and requires many PCR replicates, an alternative multiplestep genotyping method is recommended. This model enables researchers to optimize experimental protocols through pilot studies and obtain reliable genetic information using noninvasive sampling method.     

Growth, photosynthesis and podophyllotoxin accumulation of Dysosma versipellis in response to a light gradient and conservation implications

Dysosma versipellis (Hance) M. Cheng ex Ying (Berberidaceae) is a rare and vulnerable, perennial herb endemic to China with pharmaceutical significance. Increasing habitat loss and over-exploitation of the plant has severely affected the plant’s in situ conservation, necessitating ex situ conservation and commercial cultivation. The light regime is a critical environmental factor contributing to successful ex situ conservation via efficient production of biomass and secondary metabolites. We investigated th...     

Understanding atomic-scale phase separation of liquid Fe-Cu alloy

Using liquid Fe 60 Cu 40 alloy as a model, the structure of liquid Fe-Cu alloy systems is investigated in the temperature range 1200 2200 K, covering a large metastable undercooled regime, to understand the phase separation of liquid Fe-Cu alloys on the atomic scale. The total pair distribution functions (PDFs) indicate that liquid Fe 60 Cu 40 alloy is ordered in the short range and disordered in the long range. If the atom types are ignored, the total atom number densities and PDFs demonstrate that the atoms are distributed homogenously in the liquid alloy. However, the segregation of Fe and Cu atoms is very obvious with decreasing temperature. The partial PDFs and coordination numbers show that the Cu and Fe atoms are not apt to get together on the atomic scale at low temperatures; this will lead to large fluctuations and phase separation in liquid Fe-Cu alloy.     

An overview of resistive random access memory devices

With recent progress in material science, resistive random access memory (RRAM) devices have attracted interest for nonvolatile, low-power, nondestructive readout, and high-density memories. Relevant performance parameters of RRAM devices include operating voltage, operation speed, resistance ratio, endurance, retention time, device yield, and multilevel storage. Numerous resistive-switching mechanisms, such as conductive filament, space-charge-limited conduction, trap charging and discharging, Schottky Emission, and Pool-Frenkel emission, have been proposed to explain the resistive switching of RRAM devices. In addition to a discussion of these mechanisms, the effects of electrode materials, doped oxide materials, and different configuration devices on the resistive-switching characteristics in nonvolatile memory applications, are reviewed. Finally, suggestions for future research, as well as the challenges awaiting RRAM devices, are given.     

强化教育对新诊断的Ⅱ型糖尿病门诊患者生存质量的影响

目的探讨强化教育项目在改善糖尿病—Ⅱ患者生存质量中的作用.方法将84例新诊断的糖尿病—Ⅱ门诊患者随机分为强化教育组及对照组.对照组按医嘱服用药物,接受医院常规指导;强化教育组在受药物治疗和医院常规指导的基础上,接受为期3天的强化教育,及后续每3个月定期1次的随访,研究时间共12个月.研究起始及12个月末均采用糖尿病生存质量特异性量表(DSQL)进行问卷调查并评分.结果强化教育组患者12个月末的生存质量显著优于对照组(P <0.05).结论对新诊断的糖尿病—Ⅱ门诊患者进行强化教育是提高自我管理水平,改善其生存质量的有效方法