治疗先天性多拇畸形26例临床分析

目的 探讨先天性多拇畸形的治疗方法.方法 对26例先天性多拇畸形的患者进行手术,通过皮肤切口的设计,骨骼支架的建立,关节的修复,拇外展功能的重建等方面的治疗.结果 26例患者术后进行3个月至2 a的随访,拇指的外形及功能均取得满意的效果.结论 先天性多拇畸形临床治疗需综合考虑才能取得较好的疗效.     

神经营养因子联合治疗促进脊髓轴索再生的研究现状

神经营养因子（neurotrophic factors,NTFs）在急性脊髓损伤（spinal cord injury,SCI）后神经细胞的生长发育、保护和修复的过程中发挥重要作用。然而,单一的治疗尚不足以激活神经元内源性的再生程序;其次,再生抑制因子限制了NTFs对SCI后结构和功能恢复。因此,越来越多的学者选择以联合的方式探索NTFs对再生的促进作用。本文归纳了NTFs以联合的方式治疗轴索再生的基本原理和最新进展,旨在为联合治疗的进一步研究提供科学指导。     

New strategies for the repair of spinal cord injury

Spinal cord injury （SCI） leads to several neu- rologic damages to patients with sensory and motor func- tion loss. Although some inspiring results were reported in animal, even in non-human primate models, the clinical translation of these research achievements barely move forward for the SCI patients. This review mainly focused on the pathogenesis of the primary and secondary injury, the clinical therapies and the new technologies in spinal cord injury. Moreover, the key scientific issues on this field were discussed in the review. Finally, some suggestions were proposed for the scientific and clinical researches.     

Assessment of alternated cooling and heating treatment by US combined CEUS in the VX2 rabbit liver tumor model

Inoperable liver tumors are often treated by thermal ablation that destroys the tumor in situ and spares the adjacent hepatic tissue.Thermal–physical treatment has many advantages,but treatment by freezing or heating alone has some limitations.By taking the advantages and disadvantages of cryosurgery and thermotherapy into consideration,a new thermal technique that combines cryosurgery and radio frequency ablation has been proposed,thereby overcoming the disadvantages of each treatment strategy and improving therapeutic outcomes.This new approach remains to be systematically studied in the liver;therefore,this study was performed to estimate survival after alternated cooling and heating ablation therapy in a VX2 rabbit liver tumor model.Sixteen days after VX2 carcinoma implantation into the rabbit liver,tumors were treated with alternated cooling and heating ablation therapy.Rabbits were monitored for 6 months after treatment and assessed with ultrasound(US)and computed tomography at 1,7,14,and 30 days posttreatment.Untreated tumor-bearing animals served as the control group.Our results show that alternate freezing and heating ablation therapy resulted in a good recovery of VX2 rabbits.Compared with the control group,treated rabbits lived significantly longer(P\0.05),with 70%of treated animals surviving to 196 days posttreatment without metastasis or recurrence,while none of the controls did so.There was no local recurrence in the treatment group.All rabbits in the control group developed metastasis,while metastasis was only observed in 30% of treated rabbits.These results suggest that alternate cooling and heating ablation therapy can prolong the survival time of rabbits with VX2 liver tumors and is an effective method for tumor therapy.Furthermore,we also showed in this model that contrast enhanced US is a valid follow-up approach to assess treatment effectiveness.     

情侣软件 手机帮你融洽夫妻关系

在这个智能手机掌控生活的时代,即使是最私人的,最复杂的东西——爱情,都能找到方法变成应用软件。黄之燕在她一天的任何空闲时间都会下意识地掏出手机,那里有一个她和男友共同创造的虚拟的＂家＂,这是由一款名叫＂微爱＂的手机情侣应用软件提供的一项服务,情侣们可以根据自己的品位和喜好装饰一个房间,作为他们的私密空间。黄之燕承认她倾注了很大的心血,＂像回到了热恋期,用什么样的窗户,什么样的壁纸,每个细节都能够讨论很久。＂她说。她认为手机情侣应用确实提高了她和男友的亲密度。     

治疗输入性疟疾30例临床特征分析

目的了解输入性疟疾的临床特点、抗疟药治疗效果,为临床诊治提供参考依据.方法对收治的30例非洲务工疟疾患者的临床表现、实验室检查、治疗方案进行回顾性分析.结果血检疟原虫阳性19例,其中,恶性疟原虫6例,间日疟原虫5例,分型不详8例;30例中单用蒿甲醚治疗10例,青蒿琥酯治疗8例,双氢青蒿素哌喹片治疗5例,氯喹治疗1例,蒿甲醚联合双氢青蒿素哌喹片治疗6例;疗程最短2 d,最长15 d,所有病例最终均有效控制症状.结论输入性疟疾临床症状典型,有急性肝损害、急性血管内溶血、急性肾衰竭、脑型疟疾及肺病变等常见并发症,血检疟原虫阳性率较高,常用抗疟药物能有效控制症状.     

治疗良性前列腺增生药物的研究进展

良性前列腺增生是一种以前列腺增生并伴随下尿路症状为特点的常见疾病。目前治疗良性前列腺增生的药物有α-肾上腺素受体阻断剂、5α-还原酶抑制剂、植物花粉制剂以及民族医药等。现综述良性前列腺增生治疗药物的研究进展。     

2型糖尿病患者运动处方的个案研究

采用实验法通过12次测试获得受试者最大摄氧量,空腹及三餐后不同时间点血糖,不同强度、运动时间、起始时间运动后及次日晨的血糖,并对比不同运动方案的降糖效果.研究发现,该患者最大摄氧量绝对值为2.42 L/min,相对值为44.78 ml/kg/min,有氧能力较强;早、中、晚餐后血糖峰值出现时间均为餐后90min,且午餐后明显高于早、晚餐;餐后进行15min以内运动,中等强度血糖下降幅度大于低强度、较大强度;餐后进行30min运动,低强度降糖效果虽好于中等、较大强度,但运动停止后血糖反弹幅度较大,不适合该患者;餐后相同时间点（午餐后60min）进行中等强度运动30min效果好于15、45min,好于低强度30、60min;峰值前30min开始运动,运动前后血糖下降幅度大于峰值前15、45、60min.所以,该患者餐后（午餐后）60-75min开始,进行时间为15-30min、心率控制在143-147次/分中等强度跑台上的有氧运动为宜.     

奂疫关键点阻断剂点燃治疗黑色素瘤和癌症的希望

长期以来，癌症的治疗主要是通过外科手术、放疗以及使用具有细胞毒性的化疗等手段联合完成。近年来，随着科学家对癌症的细胞及分子生物学的研究不断深入，诞生了一系列新的化合物，这些化合物可以补充或替代上述传统的癌症治疗手段。例如，表l列举了针对晚期黑色素瘤的药物，其中一些可以对抗肿瘤细胞的免疫逃逸能力。     

Numerical modeling and simulation of temperature distribution uncertainty subject to ferromagnetic thermoseeds hyperthermia

In the process of ferromagnetic thermoseeds mediated magnetic induction hyperthermia, the tempera- ture distribution in the tumor region is a key factor to determine the therapy effect. During the preoperative treatment planning, discrepancies of the treatment parameters may lead to the temperature distribution uncertainty within the target area. Inaccurate prediction of temperature distribution may induce the treatment failure; therefore, it would be significant to investigate the uncertainty of tissue temperature prediction caused by the disturbance of calculation parameters. In this paper, 3D temperature field and necrosis zone of tissues in ferromagnetic thermoseeds hyperthermia are simulated by the finite volume algorithm, and effects of parameter uncertainties on the temperature distribution are revealed. Results show that selecting appropriate magnetic field parameters for treatment is a priority to guarantee therapeutic effect. Thermoseed properties and blood perfusion rate are the obvious disturbing terms for temperature distribution, while the metabolic heat of bio-tissues can often be ignored within limits. Our investigation is of importance for guiding reasonable and optimal preoperative treatment planning.