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1.
针对传统的欧氏聚类算法无法同时对近处和远处的障碍物点云进行精准检测和分割,容易造成错检和漏检的情况,提出一种欧氏聚类算法的改进方法,可以根据点云与激光雷达之间的距离动态地选择阈值,从而快速且准确地完成聚类.实验表明:该方法能同时对近处和远处的障碍物点云进行快速且准确的聚类. 相似文献
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为了研究风味和营养俱佳的低糖复合果酱,以新鲜的苹果、山楂和胡萝卜为原料,以原料比例、加糖量、复合增稠剂比例和浓缩时间为影响因素,通过单因素和正交试验确定最佳工艺配方.结果表明,低糖复合果酱最佳配方为:原料比例3:2:1(苹果:山楂:胡萝卜),加糖量20%,复合增稠剂比例1:1(果胶:黄原胶),浓缩时间18 min.在储藏6个月内,果酱的可溶性固形物和总糖含量呈下降趋势,酸度先增大后趋于稳定,菌落总数有所增加,均符合国家标准.另外,果酱储藏6个月内感官评分下降,在第6个月时,因营养成分发生变化引起口感不适. 相似文献
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构造了两类Hom-δ-Jordan李色代数,给出了Hom-δ-Jordan李色代数上交换扩张的概念,证明了Hom-δ-Jordan李色代数的等价交换扩张给出相同的表示. 相似文献
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Lei Chen Cong-Fa Huang Yi-Cun Li Wei-Wei Deng Liang Mao Lei Wu Wen-Feng Zhang Lu Zhang Zhi-Jun Sun 《Cellular and molecular life sciences : CMLS》2018,75(11):2045-2058
The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4+ and CD8+ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1+ and Tim3+ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy. 相似文献
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Margherita Ratti Andrea Lampis Jens C. Hahne Rodolfo Passalacqua Nicola Valeri 《Cellular and molecular life sciences : CMLS》2018,75(22):4151-4162
Gastric cancer is one of the most aggressive malignancies, with limited treatment options in both locally advanced and metastatic setting, resulting in poor prognosis. Based on genomic characterization, stomach tumour has recently been described as a heterogeneous disease composed by different subtypes, each of them with peculiar molecular aspects and specific clinical behaviour. With an incidence of 22% among all western gastric tumour cases, stomach cancer with microsatellite instability was identified as one of these subgroups. Retrospective studies and limited prospective trials reported differences between gastric cancers with microsatellite stability and those with instability, mainly concerning clinical and pathological features, but also in regard to immunological microenvironment, correlation with prognostic value, and responses to treatment. In particular, gastric cancer with microsatellite instability constitutes a small but relevant subgroup associated with older age, female sex, distal stomach location, and lower number of lymph-node metastases. Emerging data attribute to microsatellite instability status a favourable prognostic meaning, whereas the poor outcomes reported after perioperative chemotherapy administration suggest a detrimental role of cytotoxic drugs in this gastric cancer subgroup. The strong immunogenicity and the widespread expression of immune-checkpoint ligands make microsatellite instability subtype more vulnerable to immunotherapeutic approach, e.g., with anti-PD-L1 and anti-CTLA4 antibodies. Since gastric cancer with microsatellite instability shows specific features and clinical behaviour not overlapping with microsatellite stable disease, microsatellite instability test might be suitable for inclusion in a diagnostic setting for all tumour stages to guarantee the most targeted and effective treatment to every patient. 相似文献
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我国初步建立了财政性科技经费监管体系,但是在监督主体、监督制度等方面还存在缺陷,科技经费监督出现诸多问题。建立要加强宏观层面的统筹规划,建立由政府、承担单位和外部主体上下联动、横向联合的立体监督体系。 相似文献
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以205/55R16乘用车轮胎为研究对象,采用计算流体动力学建立了考虑胎面花纹变形的轮胎滑水分析模型;以气-液二相流数值模型分析了轮胎的滑水性能,并将临界滑水速度仿真值与NASA滑水速度预测值及轮胎发生滑水时力平衡下的速度进行对比.在此基础上,引入仿生减阻理念,研究了夹角为60°、高度为0.6mm的仿生对称V形结构对花纹沟排水量和水流阻力的影响,并将其结构特征信息等效移植到接地区轮胎花纹沟底,进行了仿生花纹轮胎的滑水性能分析.结果表明:所建滑水分析模型可用来分析轮胎滑水时的流体运动特性;相对原花纹轮胎,仿生非光滑花纹沟轮胎通过提高接地区花纹沟内水流速度,降低了胎面动水压力,提高了临界滑水速度. 相似文献