Identification and bioinformatics analysis of pseudogenes from whole genome sequence of Phaeodactylum tricornutum

Pseudogenes share sequence similarities with functional genes, but in general they have lost their protein-coding ability. The identification of pseudogenes is a very important step in genome annotation. Phaeodactylum tricornutum is a marine diatom that is rich in polyunsaturated fatty acids (PUFAs). The genome of P. tricornutum has been completely sequenced. To identify pseudogenes in P. tricornutum, we developed a pipeline to discover and characterize pseudogenes. We identified a total of 1654 ‘true’ processed pseudogenes, 714 duplicated pseudogenes and 4729 pseudogene fragments. The results of the bioinformatics analysis indicated that the genome sequence of P. tricornutum contained many pseudogenes and pseudogene fragments.     

Hierarchical power control for OFDM based LTE system

3 GPP LTE has approved uplink intra-cell power control and defined overload indicator （OI） for uplink inter-cell power contrQ1 to mitigate the inter-cell interference （ICI）, respectively. In this pa- per, we propose a hierarchical power control （ HPC ） scheme where intra-eell and inter-cell power controls interact with each other. The inter-cell power control eommand is generated by radio re- source management （RRM） entity according to the ICI-load model together with the current ICI and served load information. This ICI-load model is proposed as a guideline for coordination among cells to enable the system to approach its system specific interference over thermal noise （IoT） work area. Simulation results show that for HPC scheme, the system＇ s IoT is well controlled to fit its pre-de- fined work area and the power efficiency is improved significantly. Our proposed scheme is also ro- bust to different settings of its inter-cell power control period.     

时间成本视角下RCEP对中国的经济影响——基于GTAP模型的测算

作为潜在的最大自由贸易区以及中国应对TPP(trans-pacific partnership)的一项重要策略,RCEP(regional comprehensive economic partnership)谈判的迅速推进使其成为国际社会的热点议题,然而目前却鲜有研究在量化贸易便利性的情况下测算RCEP对中国的经济影响.本文利用改进的GTAP(global trade analysis project)模型,以时间成本量化贸易便利性,分别模拟了RCEP成员之间"关税削减"情景和"关税削减+时间成本削减"情景.发现关税削减只能使中国的GDP增长0.14%.然而,如果将时间成本的削减也纳入考虑,在"冰山效应"的拉动下,中国的GDP将增长1.41%,达到关税削减情景的10倍之多.此外,中国的消费、贸易及大部分行业的生产也都会因此受益.这说明贸易时间的减少将会给中国带来巨大经济效益,也说明忽视时间成本的定量研究严重地低估了贸易自由化潜在的正面影响.     

α-突触核蛋白异常沉积后的成分改变

神经元内α-突触核蛋白(α-syn)异常沉积见于许多神经系统变性疾病中,如帕金森氏病、路易体痴呆、多系统萎缩等.溶酶体酶是清除α-syn的主要途径之一.在溶酶体酶Cathepsin D(CD)缺乏的小鼠中,已经发现有α-syn异常沉积.为了明确溶酶体出现缺陷后,体内α-syn异常沉积的过程,对野生型和CD-/-小鼠的皮层作抗α-syn抗体的Western blot,分析了CD-/-小鼠大脑皮层内α-syn的成分改变.结果发现,α-syn单体在两种小鼠大脑皮层的可溶性和不溶性成分里均没有明显变化,α-syn其他成分CD-/-小鼠则比野生型明显增多,特别是在可溶性成分里的大小位于分子量25～37 kD之间,CD-/-小鼠有明显的带存在而野生型的没有.结果提示,溶酶体功能的正常对于α-syn的代谢有重要的作用.其功能的缺失主要是影响α-syn多倍体成分,推测体内正常的α-syn除了单体,也有多倍体存在.溶酶体功能的异常引起该平衡失调,导致大量的大分子量的α-syn异常出现,直至导致-syn聚集体的出现.     

Different effects of substrates on the morphologies of single-walled carbon nanotubes

In this work, different effects of substrates on the morphologies of single-walled carbon nanotubes （SWNTs） are studied. SWNTs were produced by floating catalytic chemical vapor deposition using CH4 as carbon source gas and Ar as carrier gas. Then the SWNTs were deposited on lithography-patterned different substrates. The as-grown SWNTs at the boundaries between SiO2 and metal were characterized by scanning electron microscopy, atomic force spectroscopy and Raman spectroscopy. It is found that SWNTs deposited on low-conductivity substrates trend to have curved morphologies and some of them form rings, while SWNTs deposited on metal sub- strates remain straight and orientated. The mechanism of these effects was also discussed, which is closely related to the thermal conductivities and the principle of energy dissipation.     

Theoretical advances of the structures and catalytic activities of small-sized gold nanoclusters

Gold nanoclusters exhibit extraordinary catalytic activities,but the dominating factor is still unclear due to the complexity of the structures.In this review,we briefly summarized the recent theoretical progress on their structures and catalytic activities.Combining the experimental and theoretical efforts,the structures of small-sized gold clusters have been explored systematically.Based on the determined structures,factors that influence the catalytic capabilities of small-sized gold clusters(Au_(16)-Au_(35))are studied using CO oxidation asa probe.The preadsorption energies of CO and O_2are found strongly correlated with catalytic activities,which could be affected by the clusters'geometries,sizes,and charge distributions.In addition,the presence of water could significantly lower the activation energy barrier of O_2 dissociation to enhance the clusters'catalytic activities.     

Growth mechanism of liquid Hg/solid β-HgS metal-semiconductor heterostructures

Density functional theory （DFT） was utilized to simulate the reactions occurred in the mixture solution of cysteine and Hg（II） ions with the ratio 〈 2. Simulation result shows that Hg ions will coordinate to cysteine by the thiol groups with the form of S-Hg2 and S-Hg3; and moreover, the content of free Hg ions can only be reduced by these two forms. OH- plays an important role in the growth of β-HgS, because its nucleophilic substitution reaction supplies plenty of Hg-S-Hg radicals, which will be adsorbed onto the surface of liquid mercury ball and form the precursor of 13-HgS（111） plane. Three valent bonds adsorption of Hg-S-Hg radicals onto the surface of Hg ball has more adsorption energy （-32.768 kcal mol-1） than that of two valent bond adsorption （-20.882 kcal - mol-1）. Hg balls will stop growing after completely covered with Hg-S-Hg radicals and their size will be limited. The growth direction of β-HgS is parallel to the ＂repel- ling＂ force, that is [111] direction in β-HgS lattice. The calculated results are in good agreement with the experimental observations, demonstrating that the DFT method can be taken as a very useful tool to interpret the solution reactions that cannot be solved by conventional methods.     

Generalized reliability measures of Kalman filtering for precise point positioning

To deal with the adverse influence of model failures on Kalman filtering (KF) estimation, it is necessary to investigate the generalized reliability theory, including the model failure detection and identification method as well as the separability and reliability theories. Although the generalized reliability theory for the least square has been discussed for many decades, the generalized reliability theory of KF is not widely discussed. Compared with the least square, KF includes not only the measurement model, but also the dynamic model. In KF, the predicted value of the state parameters from the dynamic model is considered as pseudomeasurements and combined with the observed measurements to compose the form of the least square. According to the reliability of the least square, the generalized reliability of KF is derived. Then, the dynamic model failure of precise point positioning is simulated to demonstrate the usage of the generalized reliability theory. The results show that the adverse influence of the dynamic model failure is more severe than that of the measurement model. Moreover, it is recommended that the model failure identification should always be used even if the overall model test passes. It is shown that the derived generalized reliability measures are suitable for the generalized KF estimation.