Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy

Host genetics has an important role in leprosy, and variants in the shared promoter region of PARK2 and PACRG were the first major susceptibility factors identified by positional cloning. Here we report the linkage disequilibrium mapping of the second linkage peak of our previous genome-wide scan, located close to the HLA complex. In both a Vietnamese familial sample and an Indian case-control sample, the low-producing lymphotoxin-alpha (LTA)+80 A allele was significantly associated with an increase in leprosy risk (P = 0.007 and P = 0.01, respectively). Analysis of an additional case-control sample from Brazil and an additional familial sample from Vietnam showed that the LTA+80 effect was much stronger in young individuals. In the combined sample of 298 Vietnamese familial trios, the odds ratio of leprosy for LTA+80 AA/AC versus CC subjects was 2.11 (P = 0.000024), which increased to 5.63 (P = 0.0000004) in the subsample of 121 trios of affected individuals diagnosed before 16 years of age. In addition to identifying LTA as a major gene associated with early-onset leprosy, our study highlights the critical role of case- and population-specific factors in the dissection of susceptibility variants in complex diseases.     

Lp(［0,1］)-characterizations of multi-knot piecewise linear spectral sequences

There exists a class of new orthonormal basis for L²(［0,1］), whose exponential parts are multi-knot piecewise linear functions called spectral sequences. In this paper, we show that these bases constitute bases, but not unconditional bases, for L^p(［0,1］) with 1＜p＜∞, p≠2. In addition, we give the corresponding convergence theorem in L^p, Carleson-Hunt theorem on almost everywhere convergence, Littlewood-Paley theorem and Poisson summation formula related to these bases.     

Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits

Influenza viruses cause acute respiratory infections, which are highly contagious and occur as seasonal epidemic and sporadic pandemic outbreaks. Innate immune response is activated shortly after infection with influenza A viruses (IAV), affording effective protection of the host. However, this response should be tightly regulated, as insufficient inflammation may result in virus escape from immunosurveillance. In contrast, excessive inflammation may result in bystander lung tissue damage, loss of respiratory capacity, and deterioration of the clinical outcome of IAV infections. In this review, we give a comprehensive overview of the innate immune response to IAV infection and summarize the most important findings on how the host can inappropriately respond to influenza.     

Fe76Si7.6B9.5P5C1.9合金带的纵向巨磁阻抗效应

利用单辊快淬法制备宽0.35 mm,厚0.033 mm的Fe76Si7.6B9.5P5C1.9非晶薄带,具有明显的纵向巨磁阻抗效应,最大磁阻比达到754%.氮气保护条件下进行热处理的样品,最大阻抗比和灵敏度都有明显提高,440℃退火1 h的样品最大阻抗比达到1 196%,灵敏度为715%/(A·m-1).     

洛阳智慧交通系统的行车引导系统

主要讨论了支持行车引导系统的数据库、引导基础设施、信息发布的方法及内容以及系统的主要功能.行车引导系统是洛阳智慧交通系统应用的重要组成部分,为人们的出行提供实时、准确的道路现状和通行信息以及最佳的行车路线,合理地引导城市车流,保障城市道路的快捷畅通.     

大跨度预应力框架梁应力测试技术研究

应力监测是预应力结构施工监控中的重要部分,结合工程实例介绍了基于混凝土应变测试预应力测试技术,对弥补预应力结构设计中误差,保证施工质量具有重要意义.     

N,N’—二羧甲基,N,N’—二(2,2,6,6—四甲基—1—氧基哌啶—4—氧酰甲基)乙二胺的合成

本文报道了以丙酮和EDTA为原料合成N,N'—二羧甲基,N,N'—二(2,2,6,6—四甲基—1—氧基哌啶—4—氧酰甲基)乙二胺的方法。该方法具有产率高、操作简便、易于提纯等优点。     

非线性参数最优化的几个定理

本文考虑非线性参数最优化问题:其中M X,而X和A为度量空间,f:X×A→R为一函数,将要证明有关非线性参数最优化问题定性稳定性的几个定理。     

模拟电路故障定数的理论和方法

本文研究模拟电路的故障定数问题，这是作者提出的一个新概念，在最近２０年的故障诊断研究中，涉及到故障定位和故障定值，本文首先指出，故障定数、故障定痊和故障定值三者乃是整个故障诊断的三个主题，并给出了模拟电路故障定数的理论和方法。     

An Energy-Aware Routing Protocol Based on Effective Transmission in Sensor Networks

In order to minimize the energy consumption in the discovery of the routing path, this paper introduces a novel concept of effective transmission （ET） that ensures each forwarding node is not only farther from the source node, but also nearer to the destination node with respect to its sender, An energ-aware routing protocol based on ET is proposed. It enables the energy consumption for each hop to be the least for the transmission. The simulation results show the routing protocol is effective in the performance of energy consumption comparing with some other routing protocols.