时标轴上二阶Dirichlet边值问题的弱解（英文）

采用变分方法和临界点理论研究一个时标轴上二阶Dirichlet边值问题弱解的存在性.     

仿生非光滑花纹沟对轮胎抗滑水性能的影响

以205/55R16乘用车轮胎为研究对象,采用计算流体动力学建立了考虑胎面花纹变形的轮胎滑水分析模型;以气-液二相流数值模型分析了轮胎的滑水性能,并将临界滑水速度仿真值与NASA滑水速度预测值及轮胎发生滑水时力平衡下的速度进行对比.在此基础上,引入仿生减阻理念,研究了夹角为60°、高度为0.6mm的仿生对称V形结构对花纹沟排水量和水流阻力的影响,并将其结构特征信息等效移植到接地区轮胎花纹沟底,进行了仿生花纹轮胎的滑水性能分析.结果表明:所建滑水分析模型可用来分析轮胎滑水时的流体运动特性;相对原花纹轮胎,仿生非光滑花纹沟轮胎通过提高接地区花纹沟内水流速度,降低了胎面动水压力,提高了临界滑水速度.     

青藏铁路含保温夹层路基厚度与地温关系的研究

通过对青藏铁路风火山段含有保温夹层的路基建立均匀介质分层纯导热模型并运用分层近似解法求出冻土表层的温度函数,结合Lachenbruch给出的冻土层的理论温度表达式,得到了路基填料层、保温层、地表年平均温度与正弦变化温度的振幅比三者之间的隐式方程,并应用该方程对三者之间的关系进行了分析.     

含砂雾封层在桥面铺装工程中的应用

结合含砂雾封层在国道205桥面铺装上的应用,深入分析了含砂雾封层的防水、防老化作用机理,本文系统总结了国道205桥面雾封层施工质量的控制要点,并对施工前后封层各项性能指标进行跟踪检测,分析结果表明采取含砂雾封层措施确实能对桥面早期微裂缝进行有效封水,延缓桥面病害的发生,延长沥青路面的使用寿命。     

自学考试“助学二学历”优化管理探究——以南京农业大学为例

南京农业大学作为首批"助学二学历"试点单位之一,自2010年起,在本校范围内积极开展了"助学二学历"教育工作。经过几年的实践与探索,积累了丰富的教学管理经验,同时也取得了一定的成果。本文基于南京农业大学实践经验,分析了"助学二学历"开展的现状及存在的问题,提出了增强宣传力度,提高普及水平;立足学生需求,增设优势专业;加强组织建设,完善管理体系;重视过程管理,保障教学质量等策略。对自学考试"助学二学历"优化管理进行探讨,有利于高校推进自学考试事业的发展,培养复合型人才,更好地满足社会对人才多样化需求。     

兰州黄河岸边卵石层大吨位桩基自平衡法试验研究

对兰州深安黄河大桥进行桩基自平衡法试验。在对黄河岸边的岩土层进行桩基试验时,对桩基的极限侧阻力和端阻力标准值的取值提出建议,并在兰州地区进行自平衡法桩基试验时,对桩基侧摩阻力的取值提出建议。     

弱智儿童的脑机制及教育启示探析

弱智儿童的脑机制是我国特殊教育界尚未探讨的一个领域。从智力、弱智和学习的本质出发,探讨了弱智儿童脑发育的机制和脑活动机制,认为弱智儿童脑发育的正常机制因为先天、后天的遗传异常或损伤遭到了破坏,由此导致了神经系统的传导失能,并表现为神经环路的形成困难、传导的信息堵塞和消失这些主要的神经活动特点。提出了干预或教育弱智儿童的三大措施,包括食物或物质干预、文化给予以及感官训练与文化、言语的结合。     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

Fuzzy Views on Black-Litterman Portfolio Selection Model

In this paper, views of investor are described in fuzzy sets, and two fuzzy Black-Litterman models are constructed with fuzzy views and fuzzy random views respectively. In the models, expected returns and uncertainty matrix of views are redefined and the views are formulated by fuzzy approaches suitably. Then the models are tested with data from Chinese financial markets. Empirical results show that the fuzzy random views model performs the best, and both the fuzzy models are better than the traditional ones, demonstrating that the fuzzy approaches can contain more information in the views and measure the uncertainty more correctly.     

新生代农民工收入消费统计分析——基于郑州市817位新生代农民工调查数据

近年来,我国农民工群体正处在代际更替的阶段,新生代农民工有其独特的消费观念、消费结构和消费行为。同时,新生代农民工也面临生产生活方式和消费方式的变化,其收入提高与消费行为转变更是实现我国经济转型的重要推动力。基于此,本文选取郑州市作为样本地区,对新生代农民工的收入状况、消费观念和消费行为进行实地调查,运用Logist模型分析其收入状况、消费观念对其消费行为选择的影响。最后,从改善新生代农民工收入状况、人力资本提升和消费观念的引导等方面提出科学、合理的建议。