脂联素受体与2型糖尿病

脂联素（Adiponectin）是脂肪组织分泌的一种脂肪细胞因子,具有增加脂肪酸氧化、提高葡萄糖摄取量、改善胰岛素抵抗、调控血管内皮的炎症反应等作用。正常人血浆中脂联素浓度与体质量指数（BMI）、腰臀比、空腹血糖、空腹胰岛素、甘油三酯、尿酸和瘦素呈负相关。脂联素还与肥胖、胰岛素抵抗、2型糖尿病和心血管疾病密切相关。     

血清脂联素与脑梗死的关系研究

目的研究血清脂联素(APN)水平与脑梗死的关系.方法测定123例脑梗死患者及120名健康对照者的血清脂联素(APN)、高密度脂蛋白胆固醇(HDL-C)水平、低密度脂蛋白胆固醇(LDL-C)和高敏C反应蛋白(hs-CRP)水平,并分析血清脂联素(APN)水平与脑梗死患者神经功能缺损程度评分的相关性.结果脑梗死患者血清脂联素水平明显低于健康对照组(P<0.01).经Logistic回归分析显示:血清脂联素与神经功能缺失呈负相关,血清脂联素和高密度脂蛋白胆固醇(HDL-C)水平降低、低密度脂蛋白胆固醇(LDL-C)和高敏C反应蛋白(hs-CRP)升高是脑梗死的危险因素.结论血清低脂联素水平是脑梗死的独立危险因素.     

原发性高血压患者血清脂联素和抵抗素水平的变化

目的:探讨脂联素、抵抗素水平与原发性高血压的发生、发展之间的关系.方法:原发性高血压患者114例,根据血压水平分为高血压病1级组(H1)、高血压病2级组(H2)和高血压病3级组(H3), 正常血压组(H4,对照组)40例,检测各组组的血清脂联素、抵抗素、血胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和空腹血糖;计算体质指数.结果:脂联素与收缩压、甘油三酯之间呈直线关系,收缩压、甘油三酯是影响脂联素水平的独立因素;抵抗素与舒张压、高密度脂蛋白、脂联素之间呈直线关系,舒张压、高密度脂蛋白、脂联素是影响抵抗素水平的独立因素.结论:血清脂联素的降低、抵抗素的升高是原发性高血压发生和发展进程中的重要影响因素.     

综合干预对肥胖男大学生身体形态和糖脂代谢的影响

对肥胖男大学生进行为期30 d综合干预(运动、饮食、心理辅导等)减肥,对比干预前后肥胖男大学生体重、身体脂肪量、BMI指数,体脂率,腰围,臀围等身体形态指标和空腹血糖(FBG)、空腹血清胰岛素(FIN)、空腹血脂4项(TC、TG、HDL-C、LDL-C)等血液生化指标的变化。结果显示:经过30 d的综合干预减肥,肥胖男大学生的体重、身体脂肪量、BMI指数,体脂率,腰围,臀围、腰臀比等身体形态指标以及血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、血清胰岛素(FIN)等血液生化指标均明显改善(P0.05)。结论:30 d的综合干预减肥能够改善肥胖男大学生的身体形态、改善已存在的脂代谢紊乱和胰岛素抵抗倾向。     

冠心病患者血清脂联素水平及与胰岛素抵抗、冠状动脉狭窄的关系

目的 探讨脂联素及胰岛素抵抗与冠心病（CHD）患者冠状动脉狭窄的关系。方法 选取CHD患者39例及健康对照者21例,用酶联免疫吸附法检测各组空腹血清脂联素浓度,测定各组的空腹血糖（FBG）、空腹胰岛素（FINS）等指标,采用稳态模型法计算胰岛素敏感指数（ISI）,同时进行冠状动脉造影,分析血清脂联素及ISI与冠状动脉狭窄的关系。结果 CHD组与对照组比较,存在高胰岛素血症（P〈0．05）、ISI增高（P〈0．05）和血清脂联素水平降低（P〈0．01）。随冠脉病变支数的增加,FINS和ISI明显增高,2支病变组、3支病变组FINS和ISI显著高于1支病变组（P〈0．05）。相关分析显示,冠心病各亚组,血清脂联素水平与空腹胰岛素之间呈负相关（r=-0．291,P=0．040）,与ISI呈正相关（r=0．325,P=0．021）,而与冠状动脉病变支数无明显相关。结论 血清脂联素水平,胰岛素抵抗与冠心病发生率成正比,胰岛素抵抗与冠状动脉病变程度密切相关。     

血清脂联素和炎性因子对2型肥胖糖尿病患者肾脏病变的影响

目的探讨炎症因子和脂联素与2型糖尿病(T2DM)肾脏病变之间的关联。方法 60例T2DM患者被分成肥胖组和非肥胖组。采用ELISA方法检测血液中炎性细胞因子,即血清肿瘤坏死因子(TNF-a)、白细胞介素(IL-6)、总脂联素和高分子量脂联素;同时评估肾脏病变的严重程度。结果在肥胖患者进行分析时,大量蛋白尿患者的总脂联素和高分子脂联素水平显著高于正常蛋白尿患者;而大量尿蛋白患者的TNF-a和IL-6水平水与正常蛋白尿患者无统计学差异。在非肥胖患者中,大量蛋白尿患者与正常蛋白尿患者之间总脂联素、高分子脂联素、TNF-a和IL-6均无统计学差异。逻辑回归分析显示,肥胖组中血清总脂联素和高分子脂联素与肾脏病变无显著相关性。结论总脂联素与肥胖T2DM患者肾脏病变无相关性。     

2型糖尿病合并高血压病患者踝肱指数与血清脂联素的相关性

目的比较2型糖尿病(type 2 diabetes mellitus,T2DM)与2型糖尿病合并高血压(type 2 diabetescomplicated with hypertension)患者的踝肱指数(ankle brachail,ABI)、血清脂联素(adiponectin,APN),分析影响踝肱指数、脂联素水平的相关因素。方法选择山西医科大学第二医院内分泌科就诊的符合1999年WHO制定的糖尿病诊断分型标准及高血压诊断分级标准的2型糖尿病、2型糖尿病合并高血压患者88例,以血压(收缩压>140 mmHg,舒张压>90 mmHg),分为两组;测血压、踝肱指数、空腹血糖、餐后2 h血糖、糖化血红蛋白、甘油三酯、胆固醇、高密度脂蛋白、低密度脂蛋白及血清脂联素水平。结果 2型糖尿病合并高血压组踝肱指数值低于2型糖尿病组踝肱指数值,P<0.05。2型糖尿病合并高血压组血清脂联素水平低于2型糖尿病组,差异有统计学意义(P<0.05)。结论踝肱指数及血清脂联素水平对于糖尿病大血管病变有预测意义,脂联素具有延缓糖尿病大血管病变发生的作用。     

新疆地区汉族、维吾尔族和哈萨克族脂代谢异常检出率分析

为了解新疆地区汉族、维吾尔族和哈萨克族脂代谢特征,阐明代谢综合征各指标间的相互关系,以2014年6~12月新疆维吾尔自治区人民医院门诊体检个体为研究对象,包括年龄在20~90岁之间的汉族1359名、维吾尔族172名、哈萨克族630名,收集其一般资料,检测空腹血糖、血浆总胆固醇、三酰甘油、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇等指标,并对不同民族血脂异常检出率进行分析比较。结果显示,维吾尔族体重、腰围、臀围、腰臀比、体质指数、肥胖及腹型肥胖检出率、血压,以及各项血脂指标均显著高于汉族及哈萨克族。新疆地区汉族、维吾尔族和哈萨克族体检人群血脂异常总检出率为23.23%,男性(32.40%)显著高于女性(17.61%)(P0.001);高胆固醇血症检出率、高三酰甘油血症检出率以及低密度脂蛋白胆固醇血症检出率维吾尔族显著高于汉族和哈萨克族(P0.001);各项血脂指标中除高密度脂蛋白胆固醇与体重、体质指数、腰围、臀围、腰臀比、收缩压、舒张压、空腹血糖、2 h后血糖、空腹胰岛素以及2 h后胰岛素等指标在汉族和哈萨克族人群中显著负相关,其余指标均与上述资料显著正相关(P0.01)。而在维吾尔族人群中仅有总胆固醇与身高、臀围、舒张压显著正相关,低密度脂蛋白与2 h血糖显著正相关(P0.01),其余指标之间均无显著相关性。结果表明,血脂异常的发生在民族及性别间存在显著差异,维吾尔族更易发生脂代谢紊乱,可能与其独特的遗传背景有关。     

2型糖尿病患者性别、肥胖对血中RBP4和TNF-α的影响

目的:检测不同性别2型糖尿病患者正常体重组和肥胖组的血清视黄醇结合蛋白4(RBP4)和肿瘤坏死因子α(TNF-α)水平,探讨两者与体脂,糖类、脂类代谢,胰岛素敏感性等的相关性.方法:采用HOMA-IR评价各组胰岛素敏感性,测定受试者的体重指数(BMI),腰臀比(WHR),检测空腹状态下血清RBP4、TNF-α、血糖、HbA1c、血脂和胰岛素水平.结果:超重或肥胖者,RBP4及TNF-α浓度均比体重正常者高;男性RBP4浓度均比女性高,TNF-α浓度无性别差异.RBP4与TNF-α显著正相关.Pearson相关分析:不论性别,血清RBP4和BMI、WHR、TG及HOMA-IR均有显著正相关(P<0.05).而TNF-均与腹内型肥胖、脂代谢有关,TNF-α     

An Index mechanism for multi-scale view in spatial databases

There are numerous geometric objects stored in the spatial databases. An importance function in a spatial database is that users can browse the geometric objects as a map efficiently. Thus the spatial database should display the geometric objects users concern about swiftly onto the display window. This process includes two operations:retrieve data from database and then draw them onto screen. Accordingly, to improve the efficiency, we should try to reduce time of both retrieving object and displaying them. The former can be achieved with the aid of spatial index such as R-tree, the latter require to simplify the objects. Simplification means that objects are shown with sufficient but not with unnecessary detail which depend on the scale of browse. So the major problem is how to retrieve data at different detail level efficiently. This paper introduces the implementation of a multi-scale index in the spatial database SISP (Spatial Information Shared Platform) which is generalized from R-tree. The difference between the generalization and the R-tree lies on two facets: One is that every node and geometric object in the generalization is assigned with a importance value which denote the importance of them, and every vertex in the objects are assigned with a importance value,too. The importance value can be use to decide which data should be retrieve from disk in a query. The other difference is that geometric objects in the generalization are divided into one or more sub-blocks, and vertexes are total ordered by their importance value. With the help of the generalized R-tree, one can easily retrieve data at different detail levels.Some experiments are performed on real-life data to evaluate the performance of solutions that separately use normal spatial index and multi-scale spatial index. The results show that the solution using multi-scale index in SISP is satisfying.     

Characterization of Ordovician carbonate reservoirs, southeastern Saskatchewan, Canada

The discovery of the prolific Ordovician Red River reservoirs in 1995 in southeastern Saskatchewan was the catalyst for extensive exploration activity which resulted in the discovery of more than 15 new Red River pools. The best yields of Red River production to date have been from dolomite reservoirs. Understanding the processes of dolomitization is, therefore, crucial for the prediction of the connectivity, spatial distribution and heterogeneity of dolomite reservoirs.The Red River reservoirs in the Midale area consist of 3～4 thin dolomitized zones, with a total thickness of about 20 m, which occur at the top of the Yeoman Formation. Two types of replacement dolomite were recognized in the Red River reservoir: dolomitized burrow infills and dolomitized host matrix. The spatial distribution of dolomite suggests that burrowing organisms played an important role in facilitating the fluid flow in the backfilled sediments. This resulted in penecontemporaneous dolomitization of burrow infills by normal seawater. The dolomite in the host matrix is interpreted as having occurred at shallow burial by evaporitic seawater during precipitation of Lake Almar anhydrite that immediately overlies the Yeoman Formation. However, the low δ18O values of dolomited burrow infills (-5.9‰～ -7.8‰, PDB) and matrix dolomites (-6.6‰～ -8.1‰, avg. -7.4‰ PDB) compared to the estimated values for the late Ordovician marine dolomite could be attributed to modification and alteration of dolomite at higher temperatures during deeper burial, which could also be responsible for its 87Sr/86Sr ratios (0.7084～0.7088) that are higher than suggested for the late Ordovician seawaters (0.7078～0.7080). The trace amounts of saddle dolomite cement in the Red River carbonates are probably related to "cannibalization" of earlier replacement dolomite during the chemical compaction.     

A computer generator for randomly layered structures

AcomputergeneratorforrandomlylayeredstructuresYUJia shun1,2,HEZhen hua2(1.TheInstituteofGeologicalandNuclearSciences,NewZealand;2.StateKeyLaboratoryofOilandGasReservoirGeologyandExploitation,ChengduUniversityofTechnology,China)Abstract:Analgorithmisintrod…     

Perspherical Approaches for Electrons in Atoms and Charged Excitons in Quantum Wells

Instead of following Fock’s expansion,we solve the Schrodinger equation for some quantum mechanical manybody systems such as electrons in atoms and charged excitons in quantum wells in a similar way in hyperspherical coordinates by expanding the wave functions into orthonormal complete basis sets of the hyperspherical hannonics(HHs)of hyperangles and generalized Laguerre polynomials(GLPs)of the hyperradius.This leads the equation to     

Advances in broadband wireless communications under high-mobility scenarios

Future mobile communication systems aim at providing very high data transmission rates, even in high-mobility scenarios such as high-speed wheel-track trains, maglev trains, highway vehicles, airplanes, guided missiles or spacecraft. A particularly important commercial application is the strong and increasing worldwide demand for high- speed broadband wireless communications （up to 574.8 km/ h test speeds or 380 km/h commercial speeds） in railways, providing data, voice and video services for applications such as onboard entertainment services to passengers, train control, train dispatch, train sensor status handling and sur- veillance. In such high-mobility scenarios, there are a number of communication challenges, including fast hand- over, location updating, high-speed channel modeling, estimation and equalization, anti-Doppler spreading tech- niques, fast power control, and dedicated network architec- ture. Because signal transmission in very high-speed scenarios will inevitably experience serious deterioration, it is imperative to develop key broadband mobile communi- cation techniques for such high-speed vehicles.     

Wuhan University Journal of Natural Sciences TOTAL CONTENTS

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海南岛地体及其毗邻陆缘晚中生代—新生代古地磁研究和构造演化

本文叙述了对海南岛及其毗邻大陆边缘白垩纪到第四纪地层岩石进行古地磁研究的全部工作过程。通过分析岩石中剩余磁矢量的磁偏角及磁倾角的变化,提出海南岛白垩纪以来经历的构造演化模式如下:早期伴随顺时针旋转而向南迁移,后期伴随逆时针转动并向北运移。联系该地区及邻区的地质、地球物理资料,对海南岛上述的构造地体运动提出以下认识:北部湾内早期有一拉张作用,主要是该作用使湾内地壳显著伸长减薄,形成北部湾盆地。从而导致了海南岛的早期构造运动,而海南岛后期的构造运动则主要是受南海海底扩张的影响。海南地体运动规律的阐明对于了解北部湾油气盆地的形成演化有重要的理论和实际意义。     

Scale-based spatial data model for GIS

Being the primary media of geographical information and the elementary objects manipulated, almost all of maps adopt the layer-based model to represent geographic information in the existent GIS. However, it is difficult to extend the map represented in layer-based model. Furthermore, in Web-Based GIS, It is slow to transmit the spatial data for map viewing. In this paper, for solving the questions above, we have proposed a new method for representing the spatial data. That is scale-based model. In this model we represent maps in three levels: scale-view, block, and spatial object, and organize the maps in a set of map layers, named Scale-View, which associates some given scales.Lastly, a prototype Web-Based GIS using the proposed spatial data representation is described briefly.     

Exciton Seebeck in Molecular Systems

Various applications relevant to the exciton dynamics,such as the organic solar cell,the large-area organic light-emitting diodes and the thermoelectricity,are operating under temperature gradient.The potential abnormal behavior of the exicton dynamics driven by the temperature difference may affect the efficiency and performance of the corresponding devices.In the above situations,the exciton dynamics under temperature difference is mixed with     

Achieving Unusual States of Matter Under High Pressure

The elongation method,originally proposed by Imamura was further developed for many years in our group.As a method towards O(N)with high efficiency and high accuracy for any dimensional systems.This treatment designed for one-dimensional(ID)polymers is now available for three-dimensional(3D)systems,but geometry optimization is now possible only for 1D-systems.As an approach toward post-Hartree-Fock,it was also extended to