腹部脂肪组织脂联素表达与新疆维吾尔族肥胖及2型糖尿病的相关性研究

Correlation of the Adiponectin mRNA Expression of the Intro-abdominal Fat Tissue With the Obesity and Type-2 Diabetes among Xinjiang Uygur People

To discuss the relationship between the mRNA display of the Adiponectin （APN） and Xinjiang Ugyr people＇s obesity as well as the type-2 diabetes mellitus（T2DM）.Three groups of the fat samples were collected：50 samples for normal group （18.5 kg/mE≤BMI≤24 kg/m2）; 48 samples for obesity group （BMI≥28 kg/m2）;16 samples for T2DM group （after meal blood sugar≥ 11.1 mmol/L and limosis blood sugar 〉1 7.0 mmol/L）,then detected all mRNA displays according to the RT-PCR and analyzed by SPSS17.0.All parameters in terms of the weight, the waist size,the hip size,waist-to-hip ratio and the physique index from the obesity and T2DM groups were obviously higher than the normal group was significantly higher than the obesity and T2DM group （P〈0.01）.It was found that the diffemece of relative copy data of the Adiponectin mRNA,from all groups was statistical ly significant （P〈0.01）. Meanwhile, the data of the adipose cytokines from the obesity group was also higher than that from the T2DM groups,however,there was no statistical significance （P=-0.753）. The relative copy data of the Adiponectin mRNA in Abdominal adipose tissue was negatively correlated to the BMI （r=-0.334,P=0.045）, the waist size （r=-0.053,P=-0.047） and the blood sugar level （r=-0.129,P=-0.017）.Low expression of adiponectin mRNA of the abdominal adipose tissue is one of the risk factors of Uygur people obesity and T2DM.