反相乳液原位界面聚合制备聚合物药物胶囊

利用可聚合乳化剂（12-丙烯酰氧基-9-十八烯酸，AOA），在反相乳液中进行辐射原位界面聚合，成功制备出聚苯乙烯药物胶囊．自由基引发AOA与苯乙烯在油水界面进行聚合，胶囊的壁厚与油相苯乙烯单体浓度成正比．同时，通过包裹水杨酸钠进行了药物释放试验研究．在反相乳液中，原位界面聚合可以实现简单、高效的一步法制备聚合物中空微球／胶囊．

Preparation of polymer microcapsules as drug carriers by in-situ interfacial polymerization in inverse emulsion

Polymerizable surfactant (12-acryloxy-9-octadecenoic acid, AOA) was introduced intoinverse emulsion to control the in-situ interracial polymerization induced by 60 Co γ-ray andpolystyrene microcapsules were successfully synthesized. Free-radical polymerization wasconstrained to the interface of water-in-oil emulsion by the copolymerization of AOA and styrene.The shell thickness can be controlled by monomer content, The hydrophobic hollow microsphereswere used to encapsulate a large amount of sodium salicylate directly and the controlled release ofthe drug into water at a tunable rate depended on the shell thickness. This study demonstratesthe potential of hollow microspheres, prepared from 60 Co y-ray induced in-situ interracialpolymerization, as drug carriers in controlled drug release applications.