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1.
科技查新用户数据是查新业务积累的真实而宝贵的资源,其充分利用不仅是查新业务管理的需要,可提升查新服务水平,同时还能用于挖掘更多的情报价值.调研发现,当前对科技查新用户数据的挖掘利用仍以基础性的业务管理分析为主,而增值情报价值的挖掘较少.为拓展成都文献情报中心科技查新客户群体和增值服务范围,做大做强查新业务,立足成都中心查新服务实践,依托于积累查新用户及其服务记录,在挖掘发现潜在服务对象的基础上,通过多维用户关联聚类,探讨了后期信息情报服务的精准营销与推送,分析了基于用户聚类的服务推荐存在的不足,展望了挖掘更多需求信息的推荐路径. 相似文献
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为研究飞秒光源作为链路初始光源的可行性,使用阵列波导光栅(AWG)对265 fs光纤光源进行波分解复用 复用实验。实验光源波长为1 52765~1 56505 nm,通道数为48,通道间隔为080 nm。研究发现:在分波实验中,飞秒光纤光源经过AWG后,扫描谱线3 dB带宽为064 nm ,相邻通道串扰为2726 dB,比连续光源增大502 dB;在合波实验中,观察到AWG多端口端对宽带光源的波长选择作用,验证了AWG的色散特性,发现多光束的输出谱线总体轮廓未出现太大变形;在波分解复用 复用实验中,谱线最大损耗为251 dB,输出谱线轮廓和初始光谱基本一致,信号在传输过程中未出现明显失真,证明飞秒光源作为链路初始光源的可行性。 相似文献
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Evolutionary game analysis of low-carbon behavior credit supervision of logistics enterprises 下载免费PDF全文
Based on the low-carbon obligation fulfillment of Chinese logistics enterprises, this study constructs a tripartite evolutionary game model to analyze the evolutionary process of the interaction between the local government, logistics enterprises and the public in the process of low-carbon behavior credit supervision. Then using Netlogo software, a parameter simulation experiment is conducted to determine the optimal policy for improving the effect of supervision. The results are as follows: ① The combined influence of the local government and the public can effectively change the strategic choice of enterprises and promote the low-carbon behavior of enterprises. ② In terms of improving the effect of supervision, reducing the cost of government supervision would have a highly significant effect, and reducing the cost of the public would be counterproductive. ③ Increasing the government subsidies to enterprises and the government’s fines to enterprises both have a significant effect, and the effect of improving the former is better. However, increasing the severity of higher-level governments punishing local governments will reduce the stability of the system. ④ Supervision can be more effective by increasing the public’s impact on enterprises’ earnings rather than by increasing government subsidies to the public. 相似文献
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Beatriz E. Nielsen Teresa Minguez Isabel Bermudez Cecilia Bouzat 《Cellular and molecular life sciences : CMLS》2018,75(13):2457-2471
The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional contribution of the β2 subunit, we generated heteromeric receptors with fixed stoichiometry by two different approaches comprising concatenated and unlinked subunits. Receptors containing up to three β2 subunits are functional. As the number of β2 subunits increases in the pentameric arrangement, the durations of channel openings and activation episodes increase progressively probably due to decreased desensitization. The prolonged activation episodes conform the kinetic signature of α7β2 and may have an impact on neuronal excitability. For activation of α7β2 receptors, an α7/α7 binding-site interface is required, thus indicating that the three β2 subunits are located consecutively in the pentameric arrangement. α7-positive allosteric modulators (PAMs) are emerging as novel therapeutic drugs. The presence of β2 in the pentamer affects neither type II PAM potentiation nor activation by an allosteric agonist whereas it impairs type I PAM potentiation. This first single-channel study provides fundamental basis required to decipher the role and function of the novel α7β2 receptor and opens doors to develop selective therapeutic drugs. 相似文献
7.
Sei Yoshida Regina Pacitto Ken Inoki Joel Swanson 《Cellular and molecular life sciences : CMLS》2018,75(7):1227-1239
The growth and proliferation of metazoan cells are driven by cellular nutrient status and by extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical signals that increase anabolic metabolism and macropinocytosis, an actin-dependent endocytic process in which relatively large volumes of extracellular solutes and nutrients are internalized and delivered efficiently into lysosomes. Macropinocytosis is prominent in many kinds of cancer cells, and supports the growth of cells transformed by oncogenic K-Ras. Growth factor receptor signaling and the overall metabolic status of the cell are coordinated in the cytoplasm by the mechanistic target-of-rapamycin complex-1 (mTORC1), which positively regulates protein synthesis and negatively regulates molecular salvage pathways such as autophagy. mTORC1 is activated by two distinct Ras-related small GTPases, Rag and Rheb, which associate with lysosomal membranes inside the cell. Rag recruits mTORC1 to the lysosomal surface where Rheb directly binds to and activates mTORC1. Rag is activated by both lysosomal luminal and cytosolic amino acids; Rheb activation requires phosphoinositide 3-kinase, Akt, and the tuberous sclerosis complex-1/2. Signals for activation of Rag and Rheb converge at the lysosomal membrane, and several lines of evidence support the idea that growth factor-dependent endocytosis facilitates amino acid transfer into the lysosome leading to the activation of Rag. This review summarizes evidence that growth factor-stimulated macropinocytosis is essential for amino acid-dependent activation of mTORC1, and that increased solute accumulation by macropinocytosis in transformed cells supports unchecked cell growth. 相似文献
8.
Xiuli Liu 《系统科学与复杂性》2018,31(6):1554-1570
The paper established a double filtering method (DFM) to visualize the skeleton industrial structure (SIS) of one economy and find its evolution rule. Different with the previous researches, this method is from a new view of industrial conjunctions combined by leading sectors to depict the industrial structure. It was proved that the leading sector selected by DFM must be key sector selected by Hirschman-Rasmussen method. Applied DFM to input-output tables of China, Japan and USA and MFA to Japan and USA, the results analysis showed that DFM could overtake the two main shortcomings of minimum flow analysis (MFA), scratch SIS of each economy with its own characteristics, visualize the general evolution rules of the industrial structure with crisscrossed conjunctions among leading sectors. 相似文献
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In this article we consider the growing interest in recent years in the use of documentary strategies in the wold of contemporary art, film and performing arts and explore some of the central epistemological assumptions underpinning the persistent idea that the documentary should be equated with ‘non-fiction’. Following Stella Bruzzi we argue that if documentary theory maintains objectivity as the primary measure of value, it will inevitably and continuously arrive at the conclusion that the documentary genre is fundamentally flawed. Instead, we propose to move beyond the ‘realist epistemology’ of documentary theory and focus on the ‘documentary real’, i.e. the specific performativity of the reality constructed in and by the documentary genre. In the last paragraphs, we introduce the various articles that address the “documentary real” in this special issue. 相似文献
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Patricio Atanes Inmaculada Ruz-Maldonado Ross Hawkes Bo Liu Min Zhao Guo Cai Huang Israa Mohammed Al-Amily Albert Salehi Stefan Amisten Shanta J. Persaud 《Cellular and molecular life sciences : CMLS》2018,75(16):3039-3050