Synthesis of two new thiazolidines and their hepatoprotective effects

Two new 2-substituted thiazolidine-4（R）-carboxylic acids （TCAs）, 2-glusosaminal-TCA （GIcNH2Cys） and 2-N-acetyl-glueosanlinal-TCA （GlcNAeCys）, were synthesized. Their protective effects against liver toxicity induced by acetaminophen （APAP） were investigated in a mice model. The resuits demonstrate that administration of TCAs （ i. p. , 800 mg/kg） 30 min after APAP challenge efficiently decrease ALF, AST, and LDH levels in liver. GlcNAcCys shows the best proteetive eftects, decreasing ALT, AST and LDH levels to 63%, 18.4% and 37% of the APAP group respectively. Comparison with the control showed that APAP greatly decreases total sulfhydlyl （T-SH） levels （43%）, non-protein hound sulfhydryl （NP-SH） levels （50%） and total antioxidative capabilities （57%） in the liver 24 hr after challenge. TCAs treatments 30min after APAP challenge significantly elevate sulfhydryl levels and total antioxidative capabilities. APAP administration also markedly （P 〈 0.05） increases liver lipid peroxidation to 1.65 and 1.17 times that of the control 4 hr and 24 hr after APAP administration respectively. TCAs treatments can inhibit lipid peroxidation as measured by decreased malondialdehyde （MDA） contents in liver. The histopathological results also further confirm the hepatoprotective effects of TCAs. In conclusion, our data show that TCAs, GleNAcCys particularly, have hepatoprotective anti antioxidant etfects.     

一种基于Gabor滤波器的竹节纱检测方法

竹节纱是纺织工业中广泛使用的一种花式纱,为了检测和提取织物中的竹节纱,结合人眼视觉特性,提出了一种基于Gabor滤波器的竹节纱检测方法.根据竹节纱分布的方向特性,利用Gabor滤波器的带通技术,设计了一个目标函数,通过该函数来抑制织物正常纹理的频率成分,增强了竹节纱的频率成分,从而达到了检测竹节纱的目的.大量实验结果表明,该方法获得了较好的检测效果.     

冶金因素对钢点蚀扩展的影响

选择六种冶金因素各有特点的低碳钢和一种低合金钢,通过模拟闭塞腐蚀电池实验,结合冶金特点和腐蚀形貌分析,研究冶金因素对孔蚀扩展的影响. 结果表明,钢中固溶氧量、夹杂物、钙处理、磷含量及其偏析和合金元素镍铬等对点蚀扩展有重要影响. 钢中固溶氧量高、钙处理、高磷量和高镍铬量有利于抑制蚀坑扩展.     

A study of chitosan blend film as a carrier of corneal endothelial cells

In order to evaluate the cytocompatibility and biocompatibility of a new kind of chitosan blend film as a carrier of corneal endothelial cell, rabbit corneal endothelial cells cultured in vitro were breeded onto the film. After a cell monolayer formed, the scanning electron micrography was performed. After inplanted into anterior chamber, slit lamp observation, thickness metering, specular microscopy and HE staining were performed at random time after operation to evaluate the biocompatibility. Inflammation in anterior, thickness of cornea, cell density, hexagonality and cell size of the surgical cornea were taken as the indexes of biocompatibility. The cultured cells exhibited a confluent monolayer 10 days after incubation, which proved the satisfactory cytocompatibility of this film. Biocompatibility assay results suggested the implantation feasibility of the film as a carrier of corneal endothelial cells.     

磁控溅射制备的氧化钒薄膜的结构研究

用Ｘ射线光电子谱（ＸＰＳ）,原子力显微镜（ＡＦＭ）和Ｘ射线衍射（ＸＲＤ）研究了磁控溅射制备的氧化钒薄膜的宏观、微观和电子学结构。建立了薄膜的相结构与ＸＰＳ谱中Ｖ２ｐ３／２特征峰的结合能之间的定量关系。给出了二氧化钒薄膜的ＡＦＭ像。所得到的二氧化钒热致变色薄膜的结构特性与光电特性相一致。     

功能梯度热压电带拼接功能梯度材料中裂纹对SH波的散射

讨论了功能梯度热压电带拼接功能梯度材料中裂纹对SH波的散射,借助Fourier积分变换,将所研究的问题转化成对偶积分方程,运用Copson方法将对偶积分方程变为第二类Fred-holm积分方程进行求解,最后通过数值计算,讨论了材料梯度参数,温度,波数等因素对标准动应力强度因子的影响.     

功能梯度/压电材料层合中裂纹对SH波的散射

讨论了功能梯度／压电材料层合中裂纹对SH波的散射,借助Fourier积分变换,将所研究的问题转化成对偶积分方程,运用Copson方法将对偶积分方程变为第二类Fredhohn积分方程进行求解,最后通过数值计算,讨论了材料梯度参数、波数等因素对标准动应力强度因子的影响．     

热载荷下功能梯度材料中裂纹对SH波散射问题的分析

讨论了热栽荷下功能梯度材料中裂纹对SH波的散射问题．借助Fourier积分变换,将所研究的问题转化成对偶积分方程,运用Copson方法将对偶积分方程变为第二类Fredholm积分方程进行求解,分析了材料梯度参数、温度等因素对标准化动应力强度因子的影响．     

湖泊湿地生态系统水动力、水生态数学模型研究

探析水生植物的生长机理及与外部环境物质的交换过程,凝练水生植物生长发育特征以及底泥营养物质迁移转化过程的动力特征,基于营养物质在植物-底泥-水体界面的迁移转化理论以及湖泊水动力对水生植物生长过程的响应机理,建立了水-植物-底泥耦合的湖泊湿地生态系统水动力水生态数学模型.     

Activities of the Deriviatives of Chitin on the Osbeoblast Proliferation and the Effect on Bone Strength in Ovariectomized Rats

This study intends to examine the effects of different concentrations of four kinds of degradations of chitin： glucosamine （GLC）, N-acetyl-D-glucosamine （NAG）, chitooligosaccharide（COS）, CM-chitooligosaccharide （CM-COS）—on the proliferation of MC3T3-E1 cell line cultured in vitro. Results suggest that all of the glucoses mentioned above promoted the proliferation of osteoblast, and various concentrations have different effects： the proliferation was remarkable when the concentration of GLC, NAG, COS, CM-COS was 100 , 100, 500, 500 μg/mL ,respectively. Furthermore we choose the glucosamine as the material and study the effect on the bone strength in ovariectomized rats. The results showed that the middle does of glucosamine can significantly increase the hone strength of femur in ovariectomized rats.