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Two new 2-substituted thiazolidine-4(R)-carboxylic acids (TCAs), 2-glusosaminal-TCA (GIcNH2Cys) and 2-N-acetyl-glueosanlinal-TCA (GlcNAeCys), were synthesized. Their protective effects against liver toxicity induced by acetaminophen (APAP) were investigated in a mice model. The resuits demonstrate that administration of TCAs ( i. p. , 800 mg/kg) 30 min after APAP challenge efficiently decrease ALF, AST, and LDH levels in liver. GlcNAcCys shows the best proteetive eftects, decreasing ALT, AST and LDH levels to 63%, 18.4% and 37% of the APAP group respectively. Comparison with the control showed that APAP greatly decreases total sulfhydlyl (T-SH) levels (43%), non-protein hound sulfhydryl (NP-SH) levels (50%) and total antioxidative capabilities (57%) in the liver 24 hr after challenge. TCAs treatments 30min after APAP challenge significantly elevate sulfhydryl levels and total antioxidative capabilities. APAP administration also markedly (P 〈 0.05) increases liver lipid peroxidation to 1.65 and 1.17 times that of the control 4 hr and 24 hr after APAP administration respectively. TCAs treatments can inhibit lipid peroxidation as measured by decreased malondialdehyde (MDA) contents in liver. The histopathological results also further confirm the hepatoprotective effects of TCAs. In conclusion, our data show that TCAs, GleNAcCys particularly, have hepatoprotective anti antioxidant etfects. 相似文献
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本文先给出流形P上的向量场C在余切丛T*P上拓展的表达式,继而给出C作用于或C受导子作用结果的三个命题.在此基础上,最后用公式给出关于拓展T*(C)的性质的三个命题. 相似文献
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文章是把微分流形和小波分析思想结合,交叉,渗透的一种努力。为了在流形上讨论问题,我们先在"平直空间"讨论经典的多尺度变换,包括插值逼近和平均插值逼近。 相似文献
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文章陈述了流形上微分方程、渐近级数和渐近展开等概念和相关命题,然后给出了例子,用渐近展开方法求解了微分方程。 相似文献
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文章给出了Poisson流形上李括号的一些结论,并在Poisson流形P1,P2上定义了C^∞(P1)+C^∞(P2)的{,}运算,验证了C^∞(P1)+C^∞(P2)构成李代数,其次简单讨论了Poisson辛李群. 相似文献
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本文给出积映射φ( 1 )* ×φ( 2 )* 保持积流形的黎曼联络 ,以及几个诱导联络的公式。 相似文献