基于概率图模型的危险驾驶罪刑期预测

针对司法实践中对于可解释性及预测性能的需求, 本文提出了一种基于概率图模型的量刑智能辅助方法. 该方法以量刑要素为基石建立含有隐节点的概率图模型, 由极大似然准则估计刑期分布的参数, 进而计算分布的数学期望得到预测值. 关于危险驾驶罪的实验结果表明, 概率图模型的预测准确率优于基于决策树和神经网络等的模型, 且具有良好的可解释性.     

基于改进Lagrange乘子法的交通信号配时优化研究

为提高交叉口的机动车通行效率及环境效益,采用改进罚参数来构造一种新的Lagrange乘子法对交叉路口的交通信号进行优化配时。通过权重系数建立车辆延误与尾气排放的数学模型,利用改进Lagrange乘子法进行优化,将其结果与两种典型智能算法的优化结果进行对比,并利用VISSIM(Verkehr in Stadten Simulation)微观交通可视化仿真软件进行验证。实验结果表明,该方法优化的信号配时使车辆延误降低19.89%,尾气排放量降低2.379%,可见大比例优化了交叉口的车辆延误,同时可以降低尾气排放量。     

绿色发展视域下政府环境规制对企业绿色创新的影响 ——企业环境责任的中介作用

以工业企业为对象,从绿色发展视域考察政府环境规制对企业绿色创新的影响,以及异质性企业环境责任的中介作用.结果显示:政府环境规制对绿色创新有显著正向影响,环境规制力度越大则企业绿色创新动力越强;相较于反应型环境责任,政府环境规制对前瞻型环境责任履行的促进作用更显著;环境规制对绿色创新的影响通过前瞻型企业环境责任的中介来发挥作用,而反应型企业环境责任在环境规制与绿色创新之间不具有中介作用.该研究结论为绿色发展视域下企业绿色实践与环境治理研究提供理论参考与支撑.     

De Casteljau Algorithm and Degree Elevation of Toric Surface Patches

De Casteljau algorithm and degree elevation of Bézier and NURBS curves/surfaces are two important techniques in computer aided geometric design. This paper presents the de Casteljau algorithm and degree elevation of toric surface patches, which include tensor product and triangular rational Bézier surfaces as special cases. Some representative examples of toric surface patches with common shapes are illustrated to verify these two algorithms. Moreover, the authors also apply the degree elevation of toric surface patches to isogeometric analysis. And two more examples show the effectiveness of proposed method.     

砂岩在西湖凹陷花港组交互式盖层中的作用初探

西湖凹陷花港组盖层具有砂泥岩交互式发育特征，而与泥岩伴生的砂岩类盖层的油气封闭作用研究较少。采用岩芯、镜下观察及压汞等分析方法，对砂泥岩交互式盖层中的砂岩特征进行了分析。结果表明，盖层中的砂岩可作为有效盖层，砂岩类盖层早期受沉积环境控制，含有较多的泥质而导致早期压实作用较强，加之晚期的黏土矿物转换及胶结物的发育，具备形成良好盖层的条件。在不同地区进行砂岩盖层有效性研究时应以沉积环境为基础，针对不同类型的砂岩进行成岩作用研究，并针对不同类型的砂岩样品进行实验分析以明确砂岩盖层的有效性。     

Improving the photocatalytic activity of graphitic carbon nitride by thermal treatment in a high-pressure hydrogen atmosphere

Extending visible light absorption range and suppressing the recombination of photogenerated charge carriers are always important topics in developing efficient solar-driven photocatalysts. In this study, the thermal treatment process at 400 °C in a high-pressure hydrogen atmosphere was applied to modify graphitic carbon nitride. Compared to the normal atmospheric hydrogen treatment process, this process has the merit of producing nitrogen deficient graphitic carbon nitride in high-yield. The optimal photocatalytic activity of modified graphitic carbon nitride was demonstrated by controlling the treatment duration in the hydrogen atmosphere.The changes in the crystal structure, microstructure and optical properties of carbon nitrides were investigated by several characterizations. The relationship between the photocatalytic activity and structures of graphitic carbon nitride was preliminarily established. The results obtained in this study could provide some new ways of improving the activity of graphitic carbon nitride based photocatalyst.     

Molecular function of the novel α7β2 nicotinic receptor

The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional contribution of the β2 subunit, we generated heteromeric receptors with fixed stoichiometry by two different approaches comprising concatenated and unlinked subunits. Receptors containing up to three β2 subunits are functional. As the number of β2 subunits increases in the pentameric arrangement, the durations of channel openings and activation episodes increase progressively probably due to decreased desensitization. The prolonged activation episodes conform the kinetic signature of α7β2 and may have an impact on neuronal excitability. For activation of α7β2 receptors, an α7/α7 binding-site interface is required, thus indicating that the three β2 subunits are located consecutively in the pentameric arrangement. α7-positive allosteric modulators (PAMs) are emerging as novel therapeutic drugs. The presence of β2 in the pentamer affects neither type II PAM potentiation nor activation by an allosteric agonist whereas it impairs type I PAM potentiation. This first single-channel study provides fundamental basis required to decipher the role and function of the novel α7β2 receptor and opens doors to develop selective therapeutic drugs.     

Macropinocytosis,mTORC1 and cellular growth control

The growth and proliferation of metazoan cells are driven by cellular nutrient status and by extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical signals that increase anabolic metabolism and macropinocytosis, an actin-dependent endocytic process in which relatively large volumes of extracellular solutes and nutrients are internalized and delivered efficiently into lysosomes. Macropinocytosis is prominent in many kinds of cancer cells, and supports the growth of cells transformed by oncogenic K-Ras. Growth factor receptor signaling and the overall metabolic status of the cell are coordinated in the cytoplasm by the mechanistic target-of-rapamycin complex-1 (mTORC1), which positively regulates protein synthesis and negatively regulates molecular salvage pathways such as autophagy. mTORC1 is activated by two distinct Ras-related small GTPases, Rag and Rheb, which associate with lysosomal membranes inside the cell. Rag recruits mTORC1 to the lysosomal surface where Rheb directly binds to and activates mTORC1. Rag is activated by both lysosomal luminal and cytosolic amino acids; Rheb activation requires phosphoinositide 3-kinase, Akt, and the tuberous sclerosis complex-1/2. Signals for activation of Rag and Rheb converge at the lysosomal membrane, and several lines of evidence support the idea that growth factor-dependent endocytosis facilitates amino acid transfer into the lysosome leading to the activation of Rag. This review summarizes evidence that growth factor-stimulated macropinocytosis is essential for amino acid-dependent activation of mTORC1, and that increased solute accumulation by macropinocytosis in transformed cells supports unchecked cell growth.