基于改进欧几里得聚类的激光雷达障碍物检测

针对传统的欧氏聚类算法无法同时对近处和远处的障碍物点云进行精准检测和分割,容易造成错检和漏检的情况,提出一种欧氏聚类算法的改进方法,可以根据点云与激光雷达之间的距离动态地选择阈值,从而快速且准确地完成聚类.实验表明:该方法能同时对近处和远处的障碍物点云进行快速且准确的聚类.     

石杉碱甲片联合丁苯酞软胶囊对轻度阿尔茨海默病患者认知功能的疗效观察

目的 评价石杉碱甲片联合丁苯酞软胶囊对阿尔茨海默病患者认知功能的临床疗效.方法 将100例轻度阿尔茨海默病(Alzheimer's disease,AD)患者随机分为石杉碱甲片联合丁苯酞软胶囊组(治疗组)及单独应用石杉碱甲组(对照组).治疗前及治疗90 d后分别评价两组患者简易智力状态检查(Mini-mental State Examination,MMSE)量表、事件诱发电位P300潜伏期、波幅及不良反应.结果 石杉碱甲片联合丁苯酞软胶囊组治疗90 d后,MMSE评分和P300潜伏期、波幅与治疗前比较差异均具有统计学意义(P<0.05);与单独应用石杉碱甲组比较差异具有统计学意义(P<0.05).结论 石杉碱甲片联合丁苯酞软胶囊对轻度阿尔茨海默病患者认知功能有明显改善,且优于单独应用石杉碱甲片组.     

柔性基础下不排水桩复合地基固结分析

考虑柔性基础下不排水桩复合地基中桩–土非等应变特性，推导出变荷载下不排水桩复合地基桩间土平均超静孔隙水压力的控制微分方程和求解条件。通过函数变换，基于变荷载下天然地基一维固结理论建立了相应的固结解析解，包括复合地基和桩间土中的平均超静孔隙水压力解答和复合地基整体平均固结度解答。利用有限元模拟方法验证了固结解析解的合理性，并与现有的固结度解析解进行了比较。结果表明，固结度解析解与数值模拟的结果较为吻合，计算精度高于现有的固结计算模型。采用基于等应变假设的固结计算模型分析路堤下不排水桩复合地基的固结速率，计算结果偏大。     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

基于LabVIEW与SQL server设计的浮标电源远程管理系统

针对现有海洋浮标缺乏对电源有效监控管理的问题，提出了一种基于LabVIEW与SQL server编程，结合C8051F021单片机硬件的方法，设计了岸站服务器的终端监控软件和安装于浮标上的硬件电路。通过网络或北斗通讯等实时通讯方式，实现对浮标上电源的实时监控和管理，提高了浮标电源的利用和管理的能力。     

Uncoupled PID Control of Coupled Multi-Agent Nonlinear Uncertain systems

In this paper, PID (proportional-integral-derivative) controllers will be designed to solve the tracking problem for a class of coupled multi-agent systems, where each agent is described by a second-order high-dimensional nonlinear uncertain dynamical system, which only has access to its own tracking error information and does not need to communicate with others. This paper will show that a 3-dimensional manifold can be constructed based on the information about the Lipschitz constants of the system nonlinear dynamics, such that whenever the three parameters of each PID controller are chosen from the manifold, the whole multi-agent system can be stabilized globally and the tracking error of each agent approaches to zero asymptotically. For a class of coupled first-order multi-agent nonlinear uncertain systems, a PI controller will be designed to stabilize the whole system.     

Taq酶体外合成DNA时模板错位机制的探讨

利用Taq DNA聚合酶体外合成DNA过程中,当反应体系中缺少与模板链互补配对的dNTP底物时,产物合成并不会在底物缺失位点处终止,聚合反应继续进行.为研究此复制缺陷现象,设计一系列模板用于DNA体外酶促合成.除了已知的碱基错配机制,笔者发现存在另一种"模板错位"机制,即模板中与底物非Watson-Crick互补配对的碱基位点首先进行收缩滑动,形成模板bulge结构后再继续进行酶促合成反应.这项研究有助于提高DNA样品合成保真度以及继续深入探索体外DNA合成的详细机制.     

A method for recovery of iron,titanium, and vanadium from vanadium-bearing titanomagnetite

An innovative method for recovering valuable elements from vanadium-bearing titanomagnetite is proposed. This method involves two procedures: low-temperature roasting of vanadium-bearing titanomagnetite and water leaching of roasting slag. During the roasting process, the reduction of iron oxides to metallic iron, the sodium oxidation of vanadium oxides to water-soluble sodium vanadate, and the smelting separation of metallic iron and slag were accomplished simultaneously. Optimal roasting conditions for iron/slag separation were achieved with a mixture thickness of 42.5 mm, a roasting temperature of 1200°C, a residence time of 2 h, a molar ratio of C/O of 1.7, and a sodium carbonate addition of 70 wt%, as well as with the use of anthracite as a reductant. Under the optimal conditions, 93.67% iron from the raw ore was recovered in the form of iron nugget with 95.44% iron grade. After a water leaching process, 85.61% of the vanadium from the roasting slag was leached, confirming the sodium oxidation of most of the vanadium oxides to water-soluble sodium vanadate during the roasting process. The total recoveries of iron, vanadium, and titanium were 93.67%, 72.68%, and 99.72%, respectively.     

A Novel Routing Method for Social Delay-Tolerant Networks

The lack of continuous connectivity and a complete path from source to destination makes node communication quite difficult in Delay-Tolerant Networks(DTNs). Most studies focus on routing problems in idealized network environments without considering social properties. Communication devices are carried by individuals in many DTNs; therefore, DTNs are unique social networks to some extent. To design efficient routing protocols for DTNs, it is important to analyze their social properties. In this paper, a more accurate and comprehensive metric for detecting the quality of the relationships between nodes is proposed, by considering the contact time, contact frequency, and contact regularity. An overlapping hierarchical community detection method is designed based on this new metric, and a tree structure is built. Furthermore, we exploit the overlapping community structure and the tree structure to provide message-forwarding paths from the source node to the destination node.The simulation results show that our Routing method based on Overlapping hierarchical Community Detection(ROCD) achieves better delivery rate than SimBet and Bubble Rap, the classic routing protocols, without affecting the average delay.