Development of the CAS-IBB single-particle microbeam for localized irradiation of living cells

A single-particle microbeam facility has been constructed at the Key Laboratory of Ion Beam Bioengineering (LIBB), Chinese Academy of Sciences (CAS). The system was designed to deliver a defined numbers of hydrogen ions, produced by a van de Graaff accelerator, in an energy range of 2.0-3.0 MeV, into an area smaller than that of the nucleus of an individual living cell. The beam is collimated by a borosilicate glass capillary that forms the beam-line exit. An integrated computer program recognizes the cells and locates them one by one over the microbeam exit for irradiation. We present technical details of the CAS-LIBB microbeam facility, particularly on the collimator, hardware, control program, as well as cell irradiation protocols available. Various factors contributing to the targeting and positioning precision are discussed along with accuracy measurement results.     

Mutations in SEC63 cause autosomal dominant polycystic liver disease

Mutations in PRKCSH, encoding the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum (ER), cause autosomal dominant polycystic liver disease. We found that mutations in SEC63, encoding a component of the protein translocation machinery in the ER, also cause this disease. These findings are suggestive of a role for cotranslational protein-processing pathways in maintaining epithelial luminal structure and implicate noncilial ER proteins in human polycystic disease.     

福建枇杷主要虫害种类及其防治研究

本文记述我省枇杷 4 0余种主要害虫生物学特性及防治方法 ,提供生产上参考应用     

钇基重稀土复合球化剂的应用研究

试验研究了钇基重稀土复合球化剂对球铁的铁水净化（脱硫）,球化,抗球化衰退,铸态基体组织以及机机性能的影响。结果表明,钇基重稀土复合球化剂具有脱硫,球化,抗球化衰退能力强,细化基体组织,白口倾向小及提高球铁抗拉强度和延伸率的作用,在高炉冷却壁,轧辊等关键铸件上应用可提高心部性能和成品率。     

沿空掘巷锚网梁索联合支护技术

本文结合沿空掘巷支护特点,通过数值模拟分析确定了山脚树矿21128回风巷合理煤柱的留设宽度为7 m.采用钻孔岩层结构探测技术手段对巷道围岩松动情况进行探测,确定了巷道松动圈影响范围一般在2.2 m左右,为支护方式的确定和支护参数优化提供了实际依据,提出了锚网梁索支护方案.通过FLAC3D有限差分软件分析和工程监测结果表明,巷道围岩变形在安全生产允许范围内,顶板离层较小,巷道围岩得到了有效控制.     

福建枇杷5种新害虫的初步研究

本文记述福建枇杷5种新害虫—尖凹大叶蝉、柿广翅叶蝉、伊贝鹿蛾、枇杷麦蛾和蟪蛄的形态特征及生物学特性等,供生产上应用参考。