Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy

Host genetics has an important role in leprosy, and variants in the shared promoter region of PARK2 and PACRG were the first major susceptibility factors identified by positional cloning. Here we report the linkage disequilibrium mapping of the second linkage peak of our previous genome-wide scan, located close to the HLA complex. In both a Vietnamese familial sample and an Indian case-control sample, the low-producing lymphotoxin-alpha (LTA)+80 A allele was significantly associated with an increase in leprosy risk (P = 0.007 and P = 0.01, respectively). Analysis of an additional case-control sample from Brazil and an additional familial sample from Vietnam showed that the LTA+80 effect was much stronger in young individuals. In the combined sample of 298 Vietnamese familial trios, the odds ratio of leprosy for LTA+80 AA/AC versus CC subjects was 2.11 (P = 0.000024), which increased to 5.63 (P = 0.0000004) in the subsample of 121 trios of affected individuals diagnosed before 16 years of age. In addition to identifying LTA as a major gene associated with early-onset leprosy, our study highlights the critical role of case- and population-specific factors in the dissection of susceptibility variants in complex diseases.     

Advances in identification and application of tumor antigen inducing anti-cancer responses

Tumor antigen is one of the important bases of tumor immunotherapy . With the discovery of novel tumor antigens, interest in specific immunotherapy for treatment of malignancies has increased substantially. Nowadays more and more scientists paid close attention to various tumor antigens with their roles or/and applications in anti-cancer immune responses, immune tolerance, tumor markers,     

黔西县马鬃岭井田煤层特征对比及其意义

黔西县是贵州省主要的产煤区之一。根据贵州省黔西县马鬃岭井田普查所获地质成果资料,经过系统统计分析,建立了标志层B1~B5,通过该区标志层B1~B5地质特征、地球物理特征及煤层特征的对比分析,阐明了含煤岩系煤层对比划分的方法和特点,指出了黔西县马鬃岭井田煤层、标志层特征对比的意义和作用。     

Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits

Influenza viruses cause acute respiratory infections, which are highly contagious and occur as seasonal epidemic and sporadic pandemic outbreaks. Innate immune response is activated shortly after infection with influenza A viruses (IAV), affording effective protection of the host. However, this response should be tightly regulated, as insufficient inflammation may result in virus escape from immunosurveillance. In contrast, excessive inflammation may result in bystander lung tissue damage, loss of respiratory capacity, and deterioration of the clinical outcome of IAV infections. In this review, we give a comprehensive overview of the innate immune response to IAV infection and summarize the most important findings on how the host can inappropriately respond to influenza.     

试论提升研究型学院中的教师教学积极性

国内研究型学院中教师＂重科研、轻教学＂的情况较为突出,而这一问题已严重影响到教风学风建设以及教学质量的提升。该文从研究型学院中存在的教学问题着手,挖掘出研究型学院中有利于教学工作开展的天然资源,最后提出提升研究型学院中教师教学积极性的措施和建议,以提高研究型学院教师的教学质量。     

青藏铁路低温热管应用的能量基础条件

针对青藏铁路冻土路基工程中广泛应用的低温热管,研究了其工作的能量条件和工作效果.依据观测数据对低温热管的降温效果进行了分析研究,并采用有限元方法,在实测数据作为边界条件的基础上对低温热管的30年长期工作效果的变化趋势进行了数值模拟研究.对实测数据的分析以及数值模拟计算的结果都反映出相同的趋势:热管的应用有效地降低了土体温度,并在长期工作中能够持续降低土体温度.研究表明,在气温升高趋势下,低温热管应用于寒区工程的能量基础条件未有重大改变,并能够在30年的寿命期内持续地发挥作用,使应用这种热管的冻土区路基工程热稳定性得到保证.     

洛阳智慧交通系统的行车引导系统

主要讨论了支持行车引导系统的数据库、引导基础设施、信息发布的方法及内容以及系统的主要功能.行车引导系统是洛阳智慧交通系统应用的重要组成部分,为人们的出行提供实时、准确的道路现状和通行信息以及最佳的行车路线,合理地引导城市车流,保障城市道路的快捷畅通.     

N,N’—二羧甲基,N,N’—二(2,2,6,6—四甲基—1—氧基哌啶—4—氧酰甲基)乙二胺的合成

本文报道了以丙酮和EDTA为原料合成N,N'—二羧甲基,N,N'—二(2,2,6,6—四甲基—1—氧基哌啶—4—氧酰甲基)乙二胺的方法。该方法具有产率高、操作简便、易于提纯等优点。     

圆环域裂纹端应力强度因子的光弹法测定

本文采用光测弹性力学的方法测出内压圆环带二条径向裂纹时的应力场.根据裂纹尖端附近的等差线条纹,计算了裂纹尖端的应力强度因子.并提供一种实现圆环内壁受压的新方法,即在圆环内侧放一过盈芯棒.     

国产干酵母活化方法的研究

本试验利用土豆汁、活化液、土豆汁加活化液对丹宝利和梅山两种国产干酵母分别进行了活化，并测定其发酵力。结果表明，对于丹宝利活化最佳工艺为利用活化液活化４５ｍｉｎ，对于梅山活化最佳工艺为利用５％土豆汁和活化液共同活化１５～３０ｍｉｎ，两种干酵母发酵力分别提高９０ｍｌ和１２１ｍｌ，这为国产干酵母替代进口干酵母提供了依据。