氯芬黄敏片糖衣片和薄膜衣片溶出曲线的建立和比较

建立氯芬黄敏片的溶出度测定法,采用f2因子法评价本品糖衣片与薄膜衣片溶出曲线的相似性.分析结果表明:二者溶出曲线不相似,后者具有较好的溶出速率,建议提高氯芬黄敏片的质量标准和制剂水平.该法具有较好线性关系(R=0.9999),精密度RSD为0.41%(n=6),回收率为98.4%,可作为本品的溶出度测定方法.     

用于超快激光器碳纳米饱和吸收体的研究进展

碳纳米管及石墨烯饱和吸收体与目前广泛使用的锁模器相比,具有强饱和吸收、超快恢复时间、宽带宽、高光损伤阈值、易制作以及与光纤和纳米器件兼容等优点.对用于超短脉冲激光器的碳纳米管及石墨烯饱和吸收体的制作方法进行综述,针对目前存在的问题,指出了其发展方向.     

无需重新初始化水平集的多相水平集图像分割方法

笔者提出了一种无需重新初始化水平集函数的多相变分水平集图像分割方法.根据Vese -Chan提出的多相模型的区域竞争思想,结合图像区域全局信息的能量函数作为模型的外部能量项,引入内部变形能量约束水平集函数来逼近符号距离函数,避免了重新初始化水平集函数的过程,提高了计算速度和分割效果.实验结果表明,笔者提出的模型有效地克服了传统模型需重新初始化和构造符号距离函数计算量大的缺点,而且具有全局最优分割能力和较强的抗噪性能.     

试论空三加密在地形图绘制中的应用

笔者就章丘市1：2000地形图绘制项目,按区域网法影响空三加密精度的因素主要为：影像质量、像控点选取及精度、加密点的选取及加密解算方法、加密人员的经验等,找出了影响空三加密精度的主要因素及解决办法．结合生产实践解决了1：2000地形图绘制空三加密精度问题,很好的完成地形图绘制工作,希望借此可以找到此类问题的解决办法．     

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

Since its discovery in the early 1990s the deleted in colorectal cancer (DCC) gene, located on chromosome 18q21, has been proposed as a tumour suppressor gene as its loss is implicated in the majority of advanced colorectal and many other cancers. DCC belongs to the family of netrin 1 receptors, which function as dependence receptors as they control survival or apoptosis depending on ligand binding. However, the role of DCC as a tumour suppressor remains controversial because of the rarity of DCC-specific mutations and the presence of other tumour suppressor genes in the same chromosomal region. Here we show that in a mouse model of mammary carcinoma based on somatic inactivation of p53, additional loss of DCC promotes metastasis formation without affecting the primary tumour phenotype. Furthermore, we demonstrate that in cell cultures derived from p53-deficient mouse mammary tumours DCC expression controls netrin-1-dependent cell survival, providing a mechanistic basis for the enhanced metastatic capacity of tumour cells lacking DCC. Consistent with this idea, in vivo tumour-cell survival is enhanced by DCC loss. Together, our data support the function of DCC as a context-dependent tumour suppressor that limits survival of disseminated tumour cells.     

宁夏贺兰山东麓扬黄新灌区土壤质量的演变

为系统认识宁夏贺兰山东麓扬黄新灌区土地在利用变化背景下,土壤质量演变的一般规律,用空间换时间的田间取样方法,分别从利用方式、土壤分层、利用年限的角度构建数据体系.结果表明,相对未利用对照地,耕地土壤中有机碳和盐分发生表聚现象,园地20～60cm土层中有机碳和盐分明显富集;随利用年限的延长,早期耕地和园地表层中有机碳和盐分含量都呈现先降后升的格局,但后期变化趋势出现分异.园地和耕地表层土壤中wC/N,wC/P随利用年限的延长表现出近似的变化趋势,但后期土壤中wC/N开始趋近于未利用对照地,土壤中C-N循环并未发生实质性改变.耕地、园地各自具有其独特的土地退化防治价值,但是园地具有更突出的生态适宜性,耕地长期利用下的次生退化问题依然需要关注.     

蚕丝蛋白仿生多肽RAGA16的纳米结构与性能研究

利用天然蛋白质氨基酸序列设计生物仿生材料是近年来兴起的一个热门研究领域.本文中将蚕丝蛋白特征氨基酸序列(Gly-Ala-Gly-Ala-Gly-Ser)部分引入离子互补型多肽RA-DA16-Ⅰ中,设计了新型多肽RAGA16.采用原子力显微镜(AFM)、旋转流变仪(Rheometer)、傅立叶变换红外光谱仪(FTIR)、倒置荧光显微镜等技术对多肽RAGA16的自组装结构、肽链的二级结构、流变学性能以及细胞相容性等进行研究.结果表明,蚕丝蛋白多肽序列引入后,多肽RAGA16具有自组装特性,能够自组装形成致密的纳米级三维网络结构,所形成的水凝胶力学性能明显提高,通过分析得知这可能是由于多肽二级结构中Silk Ⅰ结构成分比例增加所致.荧光染色显示,绝大多数接种于多肽水凝胶中的小鼠前成骨细胞MC3T3-E1能存活,且在不同的三维平面上生长增殖.综上,利用蚕丝蛋白特征序列对RADA16-Ⅰ进行仿生改性后,对拓展多肽材料在生物医学领域的应用具有重要意义.     

Petrogenesis of Aoyougou high-silica adakite in the North Qilian orogen, NW China: Evidence for decompression melting of oceanic slab

A trondhjemitic body occurs in the Aoyougou area,the western part of the North Qilian orogen.It is geochemically characterized by high SiO 2,Na 2 O (high Na/K),elevated Sr/Y and (La/Yb) N,positive Sr anomaly,relatively enriched large ion lithophile elements (LILEs) and light rare earth elements (LREEs),and depleted Nb,Ta,Ti,resembling the high-silica adakite.Zircon U-Pb SHRIMP dating yields a weighted mean age of 438±3 Ma.This age is significantly younger than eclogitization ages of 460-490 Ma in the North Qilian orogen,suggesting that formation of the adakite postdates the subduction of oceanic crust in association with closure of the ancient Qilian Ocean.Whole-rock Sr and Nd isotopic analyses give initial ratios of I Sr =0.7044 0.7047 and Nd (t)=3.0 4.1,indicating that they are derived from partial melting of the juvenile oceanic crust.In view of the tectonic evolution of the North Qilian orogen,the high-silica adakite was probably derived from decompression melting of the exhumed eclogite at the depth of ～60 km.     

Leptomeningeal metastasis from central nervous system tumors: A study of classification and stage in the spinal canal of 58 patients

Leptomeningeal metastasis (LM) is caused by the spread of malignant tumor cells into the subarachnoid space.However,classification and staging of LM in the spinal canal is rare in the literature.The authors reviewed the records of 58 Chinese patients with LM for clinical features,neuroimaging,and treatments.Gadolinium-enhanced magnetic resonance imaging (MRI) of brain and spinal cord were performed in all patients.Removal of intracranial tumors was performed in all patients and diagnoses were confirmed by histology.The study group consisted of 58 patients,with 29 cases presenting with intraspinal symptoms.Of the 58,8 patients underwent intraspinal tumor removal,8 received radiotherapy alone,9 received chemotherapy alone,and 34 patients received combined radiochemotherapy.We classified LM into 3 types:type L or leptomeninges LM,is subdivided into 2 subtypes (subtype LI and LII (a,b)),type N or nerve root LM is subdivided into 2 subtypes (subtype NI and NII (a,b)),and type M or mixed-type LM.We also divided LM into stages of I-IV according to the symptoms and the volume of the tumor based on spinal axial MRI.Type LI LM often occurs in patients with intracranial and intraspinal tumors found simultaneously.Patients who receive surgery for intracranial tumors may present with type N LM.Surgery is suitable for patients with NI LM and LIIb LM in stages III-IV,presenting with severe spinal symptoms.The prognosis is better for type N LM than type L LM.