| 氯芬黄敏片糖衣片和薄膜衣片溶出曲线的建立和比较 |
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| 引用本文： | 肖松,郑若纯,赖锐娟.氯芬黄敏片糖衣片和薄膜衣片溶出曲线的建立和比较[J].汕头大学学报(自然科学版),2012(4):33-36,60. |
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| 作者姓名： | 肖松 郑若纯 赖锐娟 |
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| 作者单位： | 汕头经济特区舵滨制药厂,广东汕头515041 |
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| 摘 要： | 建立氯芬黄敏片的溶出度测定法,采用f2因子法评价本品糖衣片与薄膜衣片溶出曲线的相似性.分析结果表明:二者溶出曲线不相似,后者具有较好的溶出速率,建议提高氯芬黄敏片的质量标准和制剂水平.该法具有较好线性关系(R=0.9999),精密度RSD为0.41%(n=6),回收率为98.4%,可作为本品的溶出度测定方法.
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| 关 键 词： | 氯芬黄敏片 糖衣片 薄膜衣片 溶出曲线 |
Design and Comparison of Stripping Curves of Sugar-Coated and Film-Coated Tablets |
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| XIAO Song,ZHENG Ruo-chun,LAI Rui-juan.Design and Comparison of Stripping Curves of Sugar-Coated and Film-Coated Tablets[J].Journal of Shantou University(Natural Science Edition),2012(4):33-36,60. |
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| Authors: | XIAO Song ZHENG Ruo-chun LAI Rui-juan |
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| Institution: | (Tuobin Pharmaceutical Factory, Shantou Special Economic Zone, Shantou 515041, Guangdong, China) |
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| Abstract: | In this paper, the determination method for stripping curve of Lufenhuangmin tablets is designed. The f2 factor method is used to evaluate the similarity in stripping curves of sugar-coated tablets and film-coated tablets. The results show that the stripping curves are not similar. The stripping curve of film-coated tablets is faster. The quality standard and preparation techniques will be further improved in future. The new determination method is good at linearity （R is 0.9999）, precision （RSD is 0.41;n is 6） and recovery（98.4%）. |
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| Keywords: | Lufenhuangmin tablet sugar-coated tablet film -coated tablet stripping curve |
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