诺氟沙星对氨茶碱血药浓度的影响

本文采用放射免疫分析法(RIA)对单用氨茶碱及氨茶碱与诺氟沙星合用后,慢性阻塞性肺病(COPD)患者体内茶碱血药浓度进行测定,并对两组数据进行了统计学处理。结果表明,合用诺氟沙星后,茶碱血药浓度略升高,但无显著性差异(P>0.05);组间比较茶碱血药浓度变化百分率,经t检验,P>0.05,亦无显著性差异。提示通常情形下,诺氟沙星与氨茶碱合用是较安全的。同时,茶碱RIA对于临床监测茶碱血药浓度不失为一种行之有效的方法。     

高效液相色谱法测定血清中茶碱和速尿

本文研究了反相高效液相色谱法分离和测定茶碱和速尿的诸条件,提出了液相色谱法测定和萃取血清中茶碱和速尿的新方法;该法简单、灵敏、精确。线性范围:茶碱为1—70μg/ml,速尿为0.5—100μg/ml;血清中茶碱和速尿浓度的日内与日间变异不大于5.5%。     

茶碱印迹酚醛吸附树脂吸附茶碱的热力学研究

通过静态吸附实验,对自制茶碱模板酚醛吸附树脂(TTPS)和非模板酚醛吸附树脂(NTPS)吸附茶碱状况进行比较.结果表明,在一定浓度范围内TTPS和NTPS对茶碱的吸附数据符合Langmuir方程和Freundlich方程,说明吸附是单分子层吸附和优惠吸附;对吸附数据进行数学处理,求得了茶碱在TTPS和NTPS上的吸附焓变、自由能变和吸附熵变,并对吸附行为作了合理解释.     

紫外-可见光度法测定茶碱缓释片中茶碱的研究

在H2BO3-Na2B4O7缓冲溶液中,甲酚红同茶碱会发生诱导荷移反应,使其吸收光谱发生变化.以十二烷基磺酸钠作增敏剂,常温下显色20 min,茶碱与甲酚红形成2︰1型络合物,其λmax=570 nm,摩尔吸光系数κ=5.56×105L/(mol.cm),茶碱浓度在0.10~8.00μg/mL范围内符合比尔定律,线性回归方程为A=0.064 36C 0.058 50,相关系数R=0.999 1,根据信噪比确定的检测限(S/N=3,n=3)为0.172μg/mL.该方法简单易行,准确度、灵敏度高,适用于快速、大批量地分析茶碱缓释片中的茶碱.     

茶碱对美味侧耳胞外多酚氧化酶和纤维素酶活性的影响

本文以美味侧耳为实验菌研究了茶碱对胞外多酚氧化酶和纤维素酶活性的影响.多酚氧化酶活性测定是用邻甲氧基苯酚为底物,用分光光度法测定.纤维素酶活性测定是以微晶纤维素和 CMC 为底物,用 DNS 法测定还原糖生成量.结果表明:当棉子壳培养基中茶碱浓度为0.5～2ppm 时,酶活提高极为显著,这一结果与茶碱促进菌丝生长和子实体形成的效应相吻合.     

HPLC法和FPIA法测定茶碱血清浓度的相关性

目的:建立快速测定茶碱血清浓度的高效液相色谱(HPLC)法,研究应用此法和常规的荧光偏振免疫分析(FPIA)法测定结果的相关性。方法:分别用HPLC和FPIA法测定58份茶碱血清样品,比较两种方法的测定结果。结果:HPLC法(Y)和FPIA法(X)测定的茶碱血清浓度的回归方程为Y=0.282 5+1.064X(r=0.988 1)。r的t检验显示两种方法测定结果之间的直线相关关系有显著意义(P<0.001)。结论:用HPLC法和FPIA法测定的茶碱血清浓度具有良好的相关性;与FPIA法相比,该HPLC法不仅同样具有快速、简便和准确的特点,而且检测成本较低,也可作为监测茶碱血清浓度的常规方法。     

硅胶表面茶碱分子印迹聚合物的制备和性能研究

以茶碱作为模板分子,通过对硅胶表面进行修饰后进行接枝共聚,制备了基于硅胶表面修饰的分子印迹聚合物.借助红外,元素分析,电镜等表征方法对聚合物的制备进行了评价和探讨.用紫外分光光度法考察了分子印迹聚合物对茶碱的吸附特性.实验表明这种分子印迹聚合物对茶碱表现了特异性吸附,而对相似化合物咖啡因则无吸附,并用薄层色谱对聚合物的分离性能进行了研究.     

UPLC-MS/MS测定中药制剂及保健品中茶碱的含量

为建立准确、灵敏的UPLC-MS/MS方法直接测定止咳平喘类中药制剂及保健食品中非法添加的茶碱的含量,采用Agilent ZORBAX-SB-C18柱为分析柱,以甲醇-0.1%甲酸铵(30:70)为流动相,检测波长270nm,扫描方式采用全扫描一级质谱、全扫描二级质谱以及MRM模式定量,质量数范围100~300。结果显示UPLC-MS/MS方法测定茶碱的检出限为scan模式下50ng/ml、MRM模式下0.05ng/ml;茶碱的定量限为MRM模式下0.1ng/ml,在0.1ng/ml~2.0ng/ml范围内浓度与峰面积呈良好的线性关系(r=0.9975)。该方法建立的系统能够灵敏、准确地测定止咳平喘类中药制剂及保健食品中茶碱含量。     

碳纳米管修饰电极伏安法测定茶碱

以碳纳米管修饰碳圆盘微电极为工作电极,铂丝为对电极,Ag/AgCl电极为参比电极,研究了茶碱在碳纳米管修饰电极上的电化学行为,化学修饰电极与裸电极相比,电流响应明显提高。在0.01 mol.L-1的硫酸溶液中-0.4 V的电压富集30 s,阳极化扫描,在1.1 V处有一灵敏的氧化峰,氧化峰电流和茶碱浓度在5.0×10-6~1.0×10-4 mol.L-1范围呈良好的线性关系,检测限为6×10-7 mol.L-1。对5.0×10-5 mol.L-1茶碱进行了6次的连续重复测定,相对标准偏差为1.79%,表明修饰电极稳定性良好,表面易于更新。此法用于茶叶样品中茶碱含量的测定结果满意。     

伊曲茶碱溶析结晶工艺研究

药物结晶工艺是药物工业生产流程中至关重要的环节。通过单因素实验，以伊曲茶碱晶体收率、粒度分布作为评价标准，考察结晶液初始浓度、溶析剂用量、结晶温度、陈化时间、溶析剂滴加速率等因素的影响。通过分析各种影响因素，得到伊曲茶碱较佳结晶条件：结晶液初始浓度12 mg/ml，水和DMF体积分数比3：1，滴加速率2 ml/min，结晶温度20 ℃、陈化时间60 min。通过该方案获得伊曲茶碱晶体呈短针状，收率、平均粒径（MS）、变异系数（CV）分别为93.7 %、12.6 μm、4.25，为工业上制备高质量的伊曲茶碱产品提供基础依据和参考。     

Characterization of Ordovician carbonate reservoirs, southeastern Saskatchewan, Canada

The discovery of the prolific Ordovician Red River reservoirs in 1995 in southeastern Saskatchewan was the catalyst for extensive exploration activity which resulted in the discovery of more than 15 new Red River pools. The best yields of Red River production to date have been from dolomite reservoirs. Understanding the processes of dolomitization is, therefore, crucial for the prediction of the connectivity, spatial distribution and heterogeneity of dolomite reservoirs.The Red River reservoirs in the Midale area consist of 3～4 thin dolomitized zones, with a total thickness of about 20 m, which occur at the top of the Yeoman Formation. Two types of replacement dolomite were recognized in the Red River reservoir: dolomitized burrow infills and dolomitized host matrix. The spatial distribution of dolomite suggests that burrowing organisms played an important role in facilitating the fluid flow in the backfilled sediments. This resulted in penecontemporaneous dolomitization of burrow infills by normal seawater. The dolomite in the host matrix is interpreted as having occurred at shallow burial by evaporitic seawater during precipitation of Lake Almar anhydrite that immediately overlies the Yeoman Formation. However, the low δ18O values of dolomited burrow infills (-5.9‰～ -7.8‰, PDB) and matrix dolomites (-6.6‰～ -8.1‰, avg. -7.4‰ PDB) compared to the estimated values for the late Ordovician marine dolomite could be attributed to modification and alteration of dolomite at higher temperatures during deeper burial, which could also be responsible for its 87Sr/86Sr ratios (0.7084～0.7088) that are higher than suggested for the late Ordovician seawaters (0.7078～0.7080). The trace amounts of saddle dolomite cement in the Red River carbonates are probably related to "cannibalization" of earlier replacement dolomite during the chemical compaction.     

A computer generator for randomly layered structures

AcomputergeneratorforrandomlylayeredstructuresYUJia shun1,2,HEZhen hua2(1.TheInstituteofGeologicalandNuclearSciences,NewZealand;2.StateKeyLaboratoryofOilandGasReservoirGeologyandExploitation,ChengduUniversityofTechnology,China)Abstract:Analgorithmisintrod…     

海南岛地体及其毗邻陆缘晚中生代—新生代古地磁研究和构造演化

本文叙述了对海南岛及其毗邻大陆边缘白垩纪到第四纪地层岩石进行古地磁研究的全部工作过程。通过分析岩石中剩余磁矢量的磁偏角及磁倾角的变化,提出海南岛白垩纪以来经历的构造演化模式如下:早期伴随顺时针旋转而向南迁移,后期伴随逆时针转动并向北运移。联系该地区及邻区的地质、地球物理资料,对海南岛上述的构造地体运动提出以下认识:北部湾内早期有一拉张作用,主要是该作用使湾内地壳显著伸长减薄,形成北部湾盆地。从而导致了海南岛的早期构造运动,而海南岛后期的构造运动则主要是受南海海底扩张的影响。海南地体运动规律的阐明对于了解北部湾油气盆地的形成演化有重要的理论和实际意义。     

Exciton Seebeck in Molecular Systems

Various applications relevant to the exciton dynamics,such as the organic solar cell,the large-area organic light-emitting diodes and the thermoelectricity,are operating under temperature gradient.The potential abnormal behavior of the exicton dynamics driven by the temperature difference may affect the efficiency and performance of the corresponding devices.In the above situations,the exciton dynamics under temperature difference is mixed with     

Achieving Unusual States of Matter Under High Pressure

The elongation method,originally proposed by Imamura was further developed for many years in our group.As a method towards O(N)with high efficiency and high accuracy for any dimensional systems.This treatment designed for one-dimensional(ID)polymers is now available for three-dimensional(3D)systems,but geometry optimization is now possible only for 1D-systems.As an approach toward post-Hartree-Fock,it was also extended to     

《Chinese Science Bulletin》SUBJECT INDEX TO VOLUME 59(2014)

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An on-line scaling method for improving scalability of a database cluster

The explosive growth of the Internet and database applications has driven database to be more scalable and available, and able to support on-line scaling without interrupting service. To support more client's queries without downtime and degrading the response time, more nodes have to be scaled up while the database is running. This paper presents the overview of scalable and available database that satisfies the above characteristics. And we propose a novel on-line scaling method. Our method improves the existing on-line scaling method for fast response time and higher throughputs. Our proposed method reduces unnecessary network use, i.e. , we decrease the number of data copy by reusing the backup data. Also, our on-line scaling operation can be processed parallel by selecting adequate nodes as new node. Our performance study shows that our method results in significant reduction in data copy time.     

An improved R-tree based on childnode''s probability

R-Tree is a good structure for spatial searching. But in this indexing structure,either the sequence of nodes in the same level or sequence of traveling these nodes when queries are made is random. Since the possibility that the object appears in different MBR which have the same parents node is different, if we make the subnode who has the most possibility be traveled first, the time cost will be decreased in most of the cases. In some case, the possibility of a point belong to a rectangle will shows direct proportion with the size of the rectangle. But this conclusion is based on an assumption that the objects are symmetrically distributing in the area and this assumption is not always coming into existence. Now we found a more direct parameter to scale the possibility and made a little change on the structure of R-tree, to increase the possibility of founding the satisfying answer in the front sub trees. We names this structure probability based arranged R-tree (PBAR-tree).     

An Index mechanism for multi-scale view in spatial databases

There are numerous geometric objects stored in the spatial databases. An importance function in a spatial database is that users can browse the geometric objects as a map efficiently. Thus the spatial database should display the geometric objects users concern about swiftly onto the display window. This process includes two operations:retrieve data from database and then draw them onto screen. Accordingly, to improve the efficiency, we should try to reduce time of both retrieving object and displaying them. The former can be achieved with the aid of spatial index such as R-tree, the latter require to simplify the objects. Simplification means that objects are shown with sufficient but not with unnecessary detail which depend on the scale of browse. So the major problem is how to retrieve data at different detail level efficiently. This paper introduces the implementation of a multi-scale index in the spatial database SISP (Spatial Information Shared Platform) which is generalized from R-tree. The difference between the generalization and the R-tree lies on two facets: One is that every node and geometric object in the generalization is assigned with a importance value which denote the importance of them, and every vertex in the objects are assigned with a importance value,too. The importance value can be use to decide which data should be retrieve from disk in a query. The other difference is that geometric objects in the generalization are divided into one or more sub-blocks, and vertexes are total ordered by their importance value. With the help of the generalized R-tree, one can easily retrieve data at different detail levels.Some experiments are performed on real-life data to evaluate the performance of solutions that separately use normal spatial index and multi-scale spatial index. The results show that the solution using multi-scale index in SISP is satisfying.     

Integrating GIS Web services based on mediating architecture

The geographic information service is enabled by the advancements in general Web service technology and the focused efforts of the OGC in defining XML-based Web GIS service. Based on these models, this paper addresses the issue of services chaining,the process of combining or pipelining results from several interoperable GIS Web Services to create a customized solution. This paper presents a mediated chaining architecture in which a specific service takes responsibility for performing the process that describes a service chain. We designed the Spatial Information Process Language (SIPL) for dynamic modeling and describing the service chain, also a prototype of the Spatial Information Process Execution Engine (SIPEE) is implemented for executing processes written in SIPL. Discussion of measures to improve the functionality and performance of such system will be included.