| 酒精对大鼠外侧穿通纤维-CA3区LTP诱导的影响 |
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| 引用本文： | 杨荣,杨友华,陈晓青,黄丹,HUANG Dan.酒精对大鼠外侧穿通纤维-CA3区LTP诱导的影响[J].江汉大学学报(自然科学版),2011,39(2):66-69,85. |
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| 作者姓名： | 杨荣 杨友华 陈晓青 黄丹 HUANG Dan |
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| 作者单位： | 江汉大学医学院基础部生理教研室,湖北武汉,430056 |
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| 基金项目： | 湖北省自然科学基金资助(2006AB198) |
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| 摘 要： | 目的:研究酒精对大鼠外侧穿通纤维(lateral perforant path,LPP)-CA3区(LPP-CA3)长时程增强(long-term potentiation,LTP)诱导阶段的影响及可能的机制.方法:用细胞外电生理记录方法,通过向海马CA3区分别微量注射酒精(Alcohol)、阿片受体拮抗剂纳洛酮(naloxone)和GABAA受体拮抗剂荷包牡丹碱(bicucul-line,BIC),以海马CA3区群体兴奋性突触后电位(field excitory postsynaptic potentials,fEPSP)斜率改变为指标,观察高频刺激引起的LTP诱导的变化.结果:①酒精剂量依赖性地抑制LTP的诱导;②纳洛酮和BIC均可以部分减轻酒精对LTP诱导的抑制作用.结论:内源性阿片系统和GABA能系统参与了酒精对LPP-CA3通路LTP诱导的调制.
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| 关 键 词： | 酒精 长时程增强 纳洛酮 群体兴奋性突触后电位 荷包牡丹碱 穿通纤维 |
Effects of Alcohol on Induction of Long-term Potentiation in Lateral Perforant Path-CA3 Area of Rats |
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| YANG Rong,YANG You-hua,CHEN Xiao-qing,HUANG Dan.Effects of Alcohol on Induction of Long-term Potentiation in Lateral Perforant Path-CA3 Area of Rats[J].Journal of Jianghan University:Natural Sciences,2011,39(2):66-69,85. |
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| Authors: | YANG Rong YANG You-hua CHEN Xiao-qing HUANG Dan |
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| Institution: | YANG Rong,YANG You-hua,CHEN Xiao-qing,HUANG Dan(Department of Physiology,School of Medicine,Jianghan University,Wuhan 430056,Hubei,China) |
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| Abstract: | Objective:To investigate the effect of alcohol on the induction of long-term potentiation(LTP)in lateral perforant pathway(LPP)-CA3 area of rats and its possible mechanism.Methods:Taking the method of electro-physiology record in vivo,through micro-injection of alcohol,naloxone and bicuculline respectively to hippocampal CA3 area,using the slope coefficient chang of field excitory postsynaptic potentials(fEPSP) as index,to observe the LTP induction change caused by high frequency stimulation.Results:(1) Sin... |
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| Keywords: | alcohol long-term potentiation(LTP) naloxone field excitory postsynaptic potentials bicuculline lateral perforant path(LPP) |
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