椒目仁油合用盐酸小檗碱治疗烫伤的研究

目的：考察椒目仁油对烫伤的治疗作用。方法：采用大鼠深Ⅱ度烫伤模型，创面用不同配比的椒目仁油和盐酸小檗碱进行治疗，以京万红为阳性对照药，通过观察烧伤创面愈合率、愈合时间和组织病理变化，研究椒目仁油和盐酸小檗碱合用对大鼠深Ⅱ度烫伤的治疗作用。结果：烫伤伤后第6、12、18、23天合用药组的创面愈合率随椒目仁油用量的增加而增加；椒目仁油组的脱痂时间与模型组相比有显著性差异（P<0.05）；伤后第14天，椒目仁油和盐酸小檗碱（8︰1）合用组、椒目仁油组与模型组比较成纤维细胞增殖多，真皮胶原纤维排列整齐；而模型组、溶剂组真皮胶原纤维排列较紊乱，肉芽少；伤后第21d椒目仁油组新生表皮已连接成片，表皮层厚，染色深，而模型、溶剂组新生表皮未完全覆盖创面。结论：椒目仁油可增快胶原合成，促进上皮细胞增殖，加速烧伤创面愈合。

The combined effect of the send oil from Zanthoxylum bungeanum Maxim and berberine on treatment of thermal burn

Objective: To study the effect of send oil from Zanthoxylum bungeanum Maxim and berberine hydrochloride on burn injury. Methods: The rat model with deep second-degree burns was set up and the therapeutic effects of the Zanthoxylum bungeanum Maxim send oil and berberine hydrochloride were evaluated through observing the wound healing time and ratio, and the pathological changes. Results: On the day 6, 12, 18 and 23 after burn, the healing ratio was markedly increased in the send oil group compared with the model group and the healing ratio in the combined treatment groups depended on the content of send oil. The time of decrustation in seed oil group were shorter than that in the model control (P <0.05). At 14 d after injury, send oil and berberine hydrochloride (8:1) group and seed oil group showed more fibroblast proliferation and more orderly arrangement of collagen fibers in dermis than the model group. At 21d after injury, in send oil group, newborn epidermises were connected into a film with thick epidermis compared with the model group. Conclusion: The send oil from Zanthoxylum bungeanum Maxim can speed up collagen synthesis, promote epithelial cell proliferation, and accelerate the healing of burn wound.