| 一氧化氮在心血管活动调控中的作用 |
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| 引用本文： | 白旭华,康炜东,李大力.一氧化氮在心血管活动调控中的作用[J].内蒙古民族大学学报(自然科学版),2005,20(2):198-200. |
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| 作者姓名： | 白旭华 康炜东 李大力 |
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| 作者单位： | 内蒙古民族大学,临床医学院,内蒙古,通辽,028041 |
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| 摘 要： | 一氧化氮是20年来医学研究的热点之一，一氧化氮在心血管活动调控和许多心血管疾病如高血压、动脉粥样硬化、器官缺血再灌注损伤的病理机制中都有重要作用．其作用即有有利的一方面，又有有害的一方面．在一氧化氮合酶作用下产生的一氧化氮对机体具有保护作用。另一方面，受细菌内毒素或细胞因子等诱导，一氧化氮合酶表达上调并产生大量一氧化氮引起细胞损伤和循环衰竭．目前有许多临床实验正在评价一氧化氮在心血管疾病中的作用．
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| 关 键 词： | 一氧化氮 一氧化氮合酶 高血压 动脉粥样硬化 器官缺血再灌注 |
| 文章编号： | 1671-0185(2005)02-0198-03 |
| 修稿时间： | 2004年12月18 |
Role of Nitric Oxide in Regulation of Cardiovascular Activity |
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| BAI Xu-hua,KANG Wei-dong,LI Da-li.Role of Nitric Oxide in Regulation of Cardiovascular Activity[J].Journal of Inner Mongolia University for the Nationalities(Natural Sciences),2005,20(2):198-200. |
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| Authors: | BAI Xu-hua KANG Wei-dong LI Da-li |
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| Abstract: | Nitric Oxide (NO) has been one of highlights of medical research in the last 20 years.Nitric Oxide has many important effects on regulation of cardiovascular activity and on cardiovascular diseases,such as hypertension?artherosclerosis and ischemia-reperfusion injury.Nitric Oxide has both harmful and beneficial effect in this event.On the one hand,NO derived from NO synthase (NOS) has been identified to play a protective role,on the other hand,NO induced by endotoxin or cytokines,with NOS highly expressed and producing a large amount of NO,could result in cell injury and circulation failure.Currently several clinical trials are ongoing to test the effects of NO on cardiovascular diseases. |
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| Keywords: | Nitric Oxide Nitricoxide synthase Hypertension Artherosclerosis Ischemia-reperfusion |
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