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探讨环磷酰胺(cyclophosphamide,CTX)与交流电刺激合用对小鼠U14生长的抑制效果.将右背皮下荷有U14的昆明小白鼠,随机分成4组,①D-E-,②D+E-,③D-E+,④D+E+,(D代表CTX,E代表交流电,+和-代表有和无).实验结果显示D+E+组(交流电120V,50Hz,刺激持续时间200ms,5个部位刺激,每个部位刺激2次)与D+E-相比较,有明显抑制U14的生长(P<0.05).说明环磷酰胺介导的交流电刺激为局部肿瘤的治疗提供了新思路. 相似文献
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Electrochemotherapy (ECT) is a novel cancer treatment in which electric pulses (EPs) inducing cell membrane pored (eleetroporation) are used as a means of delivering antitumor drugs to the cytoplasm of cancer cells. In vitro, with scan electromicroscope (SEM) and Trypan blue staining examination, the best parameter of EPs of electroporation is studied by the S-180 cells exposed to EP with various voltages, pulses, capacitance. The best parameter of EP of electroporation is 600V/cm, 6 pulses, 10 μF. In the in vivo study, ECT is studied with the Cytoxan (CTX) injected directly into the tumor followed immediately by a local EP at the tumor site.Four parameters, which include the tumor inhibitory ratio, the curing ratio and the vas capillareof tumor, the tumor‘s histopathological characteristics are determined and compared among the ECT group, the control group, the EP-only group and the drug-only group. The results indicate that the antitumor effect of CTX is sitrnifiezntlt enhanced by electroporation. 相似文献
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恶性肿瘤是威胁人类生命健康的主要疾患,电化学法(ECT)是近年发民起来的治疗恶性肿瘤的新技术,最常见的方法有直流电化学法和电脉冲辅助抗癌药物治疗法,根据近20年的文献资料综述了国内外学者应用电化学法治疗肿瘤的机理研究、实施方法以及在动物试验与临床应用方面的研究进展。大量的研究表明,电化学法是一种操作简便、疗效好、安全性较佳的肿瘤治疗法,目前正处于临床应用研究阶段。在此基础上,提出了一种新的电化学法即能量可控陡脉冲肿瘤治疗法,单纯利用电脉冲对细胞膜的不可逆击穿,杀死肿瘤细胞,并介绍了该方法的初期研究成果。 相似文献
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