不同铸造方法对船用螺旋桨毂成型质量的影响

采用ZCuAl9Fe4Ni4Mn2铝青铜合金为结构材料,研究3种不同铸造方法对船用桨毂组织性能的影响。结果表明,重力铸造桨毂窗口下方有大量氧化夹渣存在;低压铸造容易获得组织致密、性能优良的桨毂,但工序较多;离心铸造可获得较为致密的桨毂断面组织,二次氧化夹渣状况较重力铸造得到明显改善,但离心转速超过150r/min时,容易产生缩孔和缩松。     

9芴酮的简易还原氨化

9-芴基结构单元是重要的多功能中间体和生物活性片段,9-芴基的官能化在药物分子转换方面具有重要意义.报道了9-芴酮还原氨化的实用方法.9-芴酮与盐酸羟胺反应得9-芴酮肟,9-芴酮肟经多种还原剂还原为9-芴胺.通过条件优化,高收率(高于95%)得到9-芴肟,中等收率(锌粉还原法)制得9-芴胺,从而发现了未见文献报道的9-芴酮肟及9-芴胺合成的简便操作方法.     

SS9G型轻大修电力机车转向架悬挂参数改进设计

文中以SS9G型电力机车轻大修后的横向晃动问题为研究内容,根据机车动力学计算结果,对SS9G型轻大修机车转向架进行悬挂参数的优化设计,改善机车动力学性能。     

基于ARM9的嵌入式无线视频监控小车设计

目的将监控技术和嵌入式技术相结合,实现可移动的无线远程视频监控系统。方法在基于ARM9和linux2.6内核的嵌入式系统平台上控制摄像头采集视频、电机驱动电路以及无线网卡,并配置实现Boa服务器和MJPG-streamer视频服务器;利用CGI实现了客户端浏览器控制小车和摄像头电机的运行。结果实现了一种嵌入式视频监控小车的设计方法。结论该系统可扩展性、实时性、灵活性高,可实现对实时移动视频监控的需求。     

SSD1963驱动RGB接口LCD的设计与实现

为了解决RGB接口LCD与微控制器相连时的驱动问题,提出了一种基于SSD1963硬件电路设计方案。通过与单片机LM3S9B96进行通信调试,并对底层驱动软件进行了设计。实际测试中,利用LM3S9B96控制板和SSD1963驱动板顺利实现了图文显示。测试结果表明,硬件设计和软件驱动设计都能满足实际需求,并且工作稳定。另外,该设计方案已经在总体方案中得到应用,降低了购买带LCD控制器的成本。     

基于GMS的汽车事故求救系统设计

为了在汽车意外事故后伤者能得到及时的救援, 设计了一种基于嵌入式的汽车事故求救系统。该系统以MC9S12XS128为主控芯片, 利用三轴加速传感器MPU6050和GPS(Global Positioning System)判断车辆的姿态信息和位置信息, 并通过GSM(Global System for Mobile Communications)模块将车况数据传给呼叫中心和家
属端, 接收端对事故确认后迅速救援。测试结果证明了该系统的可靠性。     

Genome editing and animal models

Transgenic technology allows a gene of interest to be introduced into the genome of a laboratory animal, and provides an extremely powerful tool to dissect the molecular mechanisms of disease. Transgenic mouse models made by microinjection of DNA into zygotic pro- nuclei in particular have been widely used by the genetics community for 30 years. However, it remains a rather crude approach： injected sequences randomly insert in multiple copies as concatamers, they can be mutagenic, and they have variable or silenced expression depending on the site of integration, a phenomenon called position effects. As a result, multiple lines are required in order to confirm appropriate transgene expression. This can be partially overcome by flanking transgenes with insulator sequences to protect the transgene from the influence of the sur- rounding regulatory elements. Large （〈300 kb） BAC- based transgenic vectors have also been shown to be more resistant to position effects. However, animals carrying extra copies of fairly large regions of the genome could have unpredictable phenotypes. The most effective method used to control for position effects is to target transgene insertion to specific genomic loci, the so-called targeted transgenesis; for instance, the fast, site-specific transgenic technology TargattTM. The purpose of this review is to provide an overview on the current existing methods for making targeted transgenic mouse models.     

DanHong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice

Clinical observations indicate that DanHong Injection （DHI） can increase blood flow and reduce various syndromes in patients with cardiovascular disease. How- ever, it still needs to define the function of DHI and the involved mechanisms in details, such as the protective effect on the development of primary abdominal aortic aneurysms （AAAs）. In this study, we determined whether DHI is able to inhibit AAA in apoE knockout （apoE-/-） mice. Thirty apoE-/- male mice on high-fat diet （0.5 % cholesterol, 21% fat） were randomly divided into two groups and received i.p. injection of saline （100 μL/day） and DHI （100 μL/day）, respectively, for 16 weeks. At the end of experiment, we determined the development of atherosclerosis in en face aorta and aneurysms,pathological morphology of arterial wall, and serum lipid levels. We also determined the expression of monocyte chemoattractant protein-1 （MCP-1）, MMP-2, and MMP-9 mRNA in aortic wall using real-time RT-PCR. Our results indicated that high-fat diet induced the development of AAAs in apoE-/- mice, but the induction was totally blocked by DHI （P 〈 0.01）. The result of staining of abdominal aortic cross sections showed that DHI main- tained the collagen content in arterial wall, thereby pre- venting the animals from the development of AAA. Although DHI had little effect on serum total- and LDL- cholesterol levels, it reduced the expression of MCP-1, MMP-2, and MMP-9 mRNA in aortic wall （P 〈 0.01）. Taken together, our study suggests that DHI can inhibit the high-fat diet-induced AAA formation. The inhibitory effects may be related to the maintenance of the collagen content and inhibition of expression of AAA-related genes. Our study may suggest a new application of DHI in clinics.     

基于 VxWorks 的有线通信模块设计

单对线高速数字用户线技术是一种用于点对点的高速数据传输技术,可用于远距离局域网的连接,以满足用户远程的较小传输容量的企业网专线互联和对称带宽的Internet接入.基于VxWorks的有线通信模块以ARM9控制芯片作为主控芯片,完成对通信芯片SDFE-24624的参数配置和控制,也提供状态信息上报、主机控制及断线自动重连功能.模块可以不在人为干预的情况下自动运行连接,让整个模块的使用更加方便.     

源外斜坡区油侧向优势运移路径及控藏作用——以松辽盆地台9区块葡萄花油层为例

为了研究松辽台9区块葡萄花油层油成藏规律,在其油侧向运移条件研究的基础上,采用势能汇聚洼槽带为油气侧向运移优势路径的研究方法,对台9区块葡萄花油层油侧向运移优势路径及其控藏作用进行了研究。结果表明:台9区块通过油源断裂进入葡萄花油层中的油总体上由东向西发生侧向运移,发育5条优势运移路径,第2、4、5条优势运移路径分布距离相对较远,有利于油向西部长距离侧向运移;第1、3条优势运移路径分布距离相对较近,不利于油向西长距离侧向运移。圈闭只有位于油源断裂附近或位于优势运移路径上,才能形成油聚集,油气钻探为油区;否则远离油源断裂且又不在优势运移路径上的圈闭则不能形成油聚集,油气钻探则为水区。