梅花鹿宫精Ⅱ号对人体某些生理功能的影响

以新鲜梅花鹿胎盘为主要成份的保健品——梅花鹿宫精Ⅱ号,能够明显提高人体的运动能力。经检测3个人体生理指标,即本品对人体运动后肌肉耐力的影响,对人体运动性血压增幅的影响;对人体运动性心率增幅的影响。结果3项指标均显示出有意义的变化。服药5天后,给药组拉动肌力计次数比对照组增加40.36％;服药1天后,给药组血压增幅比对照组减少30.8％;服药5天后,给药组血压增幅比对照组减少48.05％;服药1天后,给药组心率增幅比对照组减少53.42％;服药5天后,给药组心率增幅比对照组减少46.28％。提示 梅花鹿宫精Ⅱ号能明显提高人体运动能力。     

Pathogenesis of Plasmodium falciparum malaria: the roles of parasite adhesion and antigenic variation

Malaria results in up to 2.5 million deaths annually, with young children and pregnant women at greatest risk. The great majority of severe disease is caused by Plasmodium falciparum. A characteristic feature of infection with P. falciparum is the accumulation or sequestration of parasite-infected red blood cells (RBCs) in various organs, such as the brain, lung and placenta, and together with other factors is important in the pathogenesis of severe forms of malaria. Sequestration results from adhesive interactions between parasite-derived proteins expressed on the surface of infected RBCs and a number of host molecules on the surface of endothelial cells, placental cells and uninfected RBCs. Some receptors for parasite adhesion have been implicated in particular malaria syndromes, such as intercellular adhesion molecule 1 in cerebral malaria and chondroitin sulfate A and hyaluronic acid in placental infection. The principal parasite ligand and antigen on the RBC surface, P. falciparum erythrocyte membrane protein 1 encoded by a multigene family termed var, is clonally variant, enabling evasion of specific immune responses. An understanding of these host-parasite interactions in the context of clinical disease and immunity may reveal potential targets to prevent or treat severe forms of malaria. Received 25 June 2001; received after revision 22 August 2001; accepted 24 August 2001     

米非司酮对人中期妊娠胎盘超微结构的影响

目的：研究米非司酮对人中期妊娠胎盘超微结构的影响。方法：运用电子显微镜对８例１７－１９孕水囊引产的孕妇引产前６ｈ空腹服用米非司酮１５０ｍｇ，胎盘出后进行超微结构的研究，并与同期１７－１９孕周水囊引产胎盘标本８例对照。结果：与对照组相比，米非司酮组功能活跃的合体滋养细胞表现没程度的退行性变，细胞滋养细胞变化不明显，绒毛间质毛细管部分内皮细胞变性，结论：米非司酮对中期妊娠胎盘组织具有损伤作用，提示米非     

Effects of acetaldehyde and/or ethanol on neutral amino acid transport systems in microvillous brush border membrane vesicles prepared from human placenta

Summary At 20 mM of acetaldehyde, the activities of three transport systems of L-alanine distinguished by the difference in their cation dependence, namely 1) Na⁺-specific, 2) Li⁺-dependent, and 3) Na⁺-independent systems, were significantly reduced in a similar manner. Only the Li⁺-dependent system was selectively inhibited at toxic concentrations of acetaldehyde and ethanol.     

MCP-1在子痫前期患者胎盘组织及血清中的表达及意义

通过比较单核细胞趋化蛋白-1（MCP-1）在正常孕妇和子痫前期患者胎盘及血清中的表达,探讨MCP-1在子痫前期发病机制中的作用。选取30例正常晚孕妇女、30例轻度子痫前期患者和30例重度子痫前期患者进行研究。采用免疫组织化学S P法检测MCP-1在胎盘组织中的表达;采用酶联免疫吸附法（ELISA）检测血清MCP-1水平。结果：子痫前期患者胎盘组织和血清中MCP-1的表达均高于正常妊娠组,差异有统计学意义（P〈0.01）,且随着病情加重而递增;子痫前期患者胎盘组织MCP-1表达与血清MCP-1水平呈显著正相关（r=0.725,P〈0.01）。结果表明,MCP-1在子痫前期患者胎盘与血清中的表达均升高,提示MCP-1在子痫前期的发生、发展中可能起着重要的作用。     

中央性前置胎盘41例临床分析

目的探讨中央性前置胎盘的发病原因及处理方法。方法对2002～2008年41例中央性前置胎盘患者的临床资料进行回顾性分析。结果住院分娩产妇4489例中,中央性前置胎盘41例,发生率0．8％,其中胎盘植入5例,孕产妇死亡率为0,新生儿窒息4例,新生儿存活率100％。结论对中央性前置胎盘选择合适的处理方法很重要,积极期待疗法加适时的手术处理有助于降低母婴死亡率和发病率。     

胎盘免疫调节因子的实验研究

报道了改良的胎盘免疫调节因子（ＰＦ）提取方法，并对制备的ＰＦ理化性质，生物学活性，急性及长期毒性进行了系统的研究，结果表明ＰＦ由３个组分构成，分子量为３８００～５０００属核酸和多肽物质，性能稳定，有明显提高机体细胞免疫功能作用毒性试验证实ＰＦ无毒副作用，长期应用完全，初步临床应用结果提示ＰＦ对鼻咽癌，结核及慢性乙肝患者免疫功能提高作用。     

强啡肽(DYN)对人胎盘绒毛组织促性腺素分泌的影响

用胎盘绒毛组织体外孵育法(无血清培液)研究了强啡肽对妊娠6～10周人胎盘绒毛组织分泌促性腺素的影响.结果表明,当DYN浓度为10~(-9)mol/L,与对照组相比,有明显的刺激作用(P<0.05);浓度为10~(-10)mol/L,刺激作用最强(p<0.001).DYN可能在胎盘绒毛组织分泌hCG中起重要作用.     

前置胎盘发病率及预后相关因素的研究

通过对219例前置胎盘临床资料的分析，结果显示：流产、剖宫产史、孕产次数与前置胎盘发病率密切相关，孕产次数增多，则前置胎盘发病率增高，有流产、剖宫产史，其前置胎盘发病率明显增高。围产儿病死率的降低与孕妇能按时产前检查、及时B超检查、早期诊断、积极治疗有关。     

羊胎盘活细胞素对小鼠机体功能的影响

小鼠腹腔注射羊胎盘活细胞素（SPLCC）后，检测其胸，脾指数，免疫细胞数量，缺氧耐受性及其胃肠推动能力，结果表明SPLCC能有效地增加小鼠外周血白细胞数和脾脏有核细胞数，增加胸，脾旨数，提高其缺氧耐受性，共小鼠功能有一定的改善。