MCP-1在子痫前期患者胎盘组织及血清中的表达及意义

通过比较单核细胞趋化蛋白-1（MCP-1）在正常孕妇和子痫前期患者胎盘及血清中的表达,探讨MCP-1在子痫前期发病机制中的作用。选取30例正常晚孕妇女、30例轻度子痫前期患者和30例重度子痫前期患者进行研究。采用免疫组织化学S P法检测MCP-1在胎盘组织中的表达;采用酶联免疫吸附法（ELISA）检测血清MCP-1水平。结果：子痫前期患者胎盘组织和血清中MCP-1的表达均高于正常妊娠组,差异有统计学意义（P〈0.01）,且随着病情加重而递增;子痫前期患者胎盘组织MCP-1表达与血清MCP-1水平呈显著正相关（r=0.725,P〈0.01）。结果表明,MCP-1在子痫前期患者胎盘与血清中的表达均升高,提示MCP-1在子痫前期的发生、发展中可能起着重要的作用。

Expression and Significance of MCP-1 in Placenta and Serum of Preeclampsia Women

Objective To study the expression of monocyte chemoattractant protein-1（MCP-1） in placenta and in serum of preeclampsia and normal pregnant,thus to detect its role in the pathogenesis of preeclampsia.Methods Thirty normal pregnant women（control group）,thirty women with mild preeclampsia and thirty women with severe preeclampsia were selected randomly in this study.Localization and expression of MCP-1 in placenta were determined by immunohistochemistry.The levels of serum MCP-1 were determined by enzyme-linked immunosorbent assay.Results（1） The level of MCP-1 in placenta and in serum of the preeclampsia group were significantly higher than control group（P〈0.01）,which were increased gradually with the condition getting more serious.（2） A significant positive correlation was observed between MCP-1 expression in placenta and serum MCP-1 level of the preeclampsia group（r = 0.725,P〈0.01）.Conclusion MCP-1 expression in placenta and in serum increased significantly of the preeclampsia group,which suggested that MCP-1 was associated with the occurrence and development of the preeclampsia.