Preparation of (R)-and (S)-2-Allyl-1,3,2-Dinaphtho(α,β)[d.f]dioxaborepin and Their Reactions with Aldehydes

0　IntroductionEnantiopure 1,1′ bi 2 naphtholspossessingC2 chiralityhaveprovedtobeversatilechiralauxiliariesinanumberofasym metricreactions[1 \|6] .Althoughsomeboroncompoundsofthemhavebeenprepared[7 1 6] ,chemistryoftheirallylboranederivativeshasneverbeenreported .Toexplorepossibilityofapplyingseven memberedcyclicchrialallylboronateesterstoasymmetricsynthesisofchiralβ alkenylalcohols,whichareimportantintermediateinthepreparationofopticallyactivenaturalproducts,werecentlyat temptedtosynthesi…     

水相中6-甲基-6-苯基-7-烯-1,5-辛二醇的合成

以DHP为原料,通过在锌介入下水相中的烯丙基化反应,合成目标产物6 甲基 6 苯基 7 烯 1,5 辛二醇.产物结构经核磁共振光谱、红外光谱和质谱得到了证实.     

Synthesis of Chiral Sulfoxides and Application in Enantioselective Allylation of Aldehydes with Allyltrichlorosilane

1 Results The enantioselective addition of allylic organometallic reagents to aldehydes is a fundamental tool in organic synthesis.The high degree of both diastereo-and enantioselectivity gives the possibility to obtain a wide series of homoallylic alcohols,versatile intermediates in a great number of synthesis[1]. One of the most successful approaches is related to the discovery that organocatalytic activation of the nucleophilic allyltrichlorosilanes by means of neutral Lewis bases,such as formamides,...     

1,3-二羰基化合物烯丙基化构建季碳中心的反应研究

许多天然产物和药物活性分子往往因为季碳中心的存在而表现出更好的理化性质和生物活性.文章首先以氢化钠作碱,利用酮和酯反应得到了一系列的α-取代-1,3-二羰基化合物,收率50%～87%;然后进一步通过烯丙基化反应成功合成了具有3个官能团(2个羰基和1个烯基)的季碳砌块,产率为50%～93%.并对合成的α-取代-1,3-二羰基化合物和烯丙基化产物进行了1H NMR表征.     

离子液体中的烯丙基化反应研究进展

文章综述了近年来离子液体中的烯丙基化反应的研究进展,如Tsuji-Trost反应,Sakurai反应,Barbier烯丙基化反应,Markovnikov烯丙基化反应,烯丙基胺化反应等.表明离子液体作为一种新型的绿色溶剂可有效促进烯丙基化反应的进行,显著地提高了反应的选择性和产率.     

Preparation of New Chiral Ferroceny Phosphine Ligands and Their Application to Organic Synthesis

1 Results The unique structure of chiral ferrocenes allows one to design a variety of chiral phosphine ligands,which are useful tools for metal catalyzed asymmetric reactions.Although some useful chiral ferrocenyl phosphine ligands have already been reported,it is still an challenging subject tocreate new ferrocenyl phosphine ligands in order to cover asymmetric reactions in which conventional ligands do not effectively work[1].We happned to discover that 1,5-dilithiation of o-TMS blocked ferrocene 1 pr...     

Preparation of (R)- and (S)-2-Allyl-1, 3, 2-dinaphtho (α, β) [d.f] dioxaborepin and their reactions with aldehydes

(R)- and(S)-2-Allyl-1,3,2-dinaphtho (α,β) [d.f] dioxaborepin ((R)-2 and(S)-2) have been first prepared by the reaction of(R)-(+)- or(S)-(−)-1, 1′-bi-2-naphthol and triallylborane in THF at room temperature, respectively.(S)-2 and(R)-2 are sensitive to moisture and oxygen in air and disproportionate easily to triallylborane and 1,1′-bi-2 naphthyl bis (1,1′-bi-2-naphtholborate) at ambient temperature. However, THF is a stabilizer for them. The reactions of(R)-2 or(S)-2 and some aliphetic or aromatic aldehydes in CH₂Cl₂ at −78°C for several hours afforded β-alkylenyl alcohols in up to 84.8%ee. Among them, optically active 1-(3, 5-dichlorophenyl)-3-butenol and 1-(2-methoxyphenyl)-3-butenol were first prepared Foundation item: Supported by the National Natural Science Foundation of China (29972033) Biography: Liu Dejun (1973), male, Ph. D, research direction: asymmetric synthesis     

Sn粉催化苯甲醛的水相烯丙基化反应研究

文章在室温和以低浓度酸或酸式盐溶液作为助催化剂的情况下,研究了Sn粉催化的苯甲醛的水相烯丙基化反应。研究结果表明:Sn粉与0.1 mol.L-1酸或酸式盐组成的催化体系都具有不同程度的催化活性,其中Sn粉与0.1 mol.L-1对甲苯磺酸溶液、0.1 mol.-L1酒石酸氢钠溶液组成的催化体系的反应产率分别高达82.1%和69.2%。     

水相中相转移催化剂和金属促进的高效羰基化合物烯丙基化反应

应用四丁基淀化铵(TBAB)、β—环糊精(β—CD)和四氟硼酸盐(MBF4)作为催化剂，在纯水中加入锡或锌能促进羰基化合物的烯丙基化反应顺利地进行，得到相应的高产率烯丙基化产物。     

Synthesis and Application of a Novel Perfluorooctylated Citric Acid

A novel perfluorooctylated citric acid was synthesized successfully via allylation of triethyl citrate followed by perfluorooctylation, reduction and hydrolysis. The fabrics treated with this compound showed good oil repellent and moderate water repellent properties; the oil repellent rating and the water repellent score were 6 and 80 respectively. Even after 10 washing cycles, the repellent properties were kept at the same level. The finished fabrics also showed some wrinkle-resistant properties, and the dry wrinkle recovery angle was increased by 53°compared with untreated fabrics. The critical surface energy of the treated fabric surface was 20±1 mN/m. This multifunctional compound also showed good water solubility, which would be beneficial for the environmental protection.