全文获取类型
收费全文 | 9365篇 |
免费 | 767篇 |
国内免费 | 225篇 |
专业分类
系统科学 | 1280篇 |
丛书文集 | 127篇 |
教育与普及 | 79篇 |
理论与方法论 | 309篇 |
现状及发展 | 879篇 |
研究方法 | 7篇 |
综合类 | 7676篇 |
出版年
2024年 | 7篇 |
2023年 | 42篇 |
2022年 | 85篇 |
2021年 | 89篇 |
2020年 | 79篇 |
2019年 | 38篇 |
2018年 | 777篇 |
2017年 | 784篇 |
2016年 | 498篇 |
2015年 | 173篇 |
2014年 | 173篇 |
2013年 | 177篇 |
2012年 | 486篇 |
2011年 | 1158篇 |
2010年 | 1004篇 |
2009年 | 670篇 |
2008年 | 740篇 |
2007年 | 971篇 |
2006年 | 181篇 |
2005年 | 230篇 |
2004年 | 260篇 |
2003年 | 307篇 |
2002年 | 305篇 |
2001年 | 248篇 |
2000年 | 140篇 |
1999年 | 135篇 |
1998年 | 72篇 |
1997年 | 74篇 |
1996年 | 77篇 |
1995年 | 53篇 |
1994年 | 52篇 |
1993年 | 50篇 |
1992年 | 42篇 |
1991年 | 48篇 |
1990年 | 41篇 |
1989年 | 26篇 |
1988年 | 23篇 |
1987年 | 24篇 |
1986年 | 8篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1967年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
1.
为了能利用单一传感器在跌倒撞击前实时检测出跌倒即将发生,结合支持向量机(SVM)和阈值法设计了一种自适应跌倒前实时检测方法.实验结果表明,该方法能在跌倒撞击前实时检测出跌倒即将发生,且比人工阈值法和SVM方法有更长的间隔时间,比SVM方法有更高的召回率和特异度. 相似文献
2.
目的 分析产后早期肛提肌裂孔扩张的影响因素.方法 盆底超声测量产后早期女性肛提肌裂孔面积,其中研究组为105名肛提肌裂孔扩张者,对照组为145名肛提肌裂孔正常者,对肛提肌裂孔扩张的相关因素进行二元Logistic回归分析.结果 研究组中盆底疾病的发生率高于对照组(P<0.05),Logistic回归分析显示第二产程时间、胎儿体重、催产素使用和盆腔器官脱垂与肛提肌裂孔扩张显著相关(P<0.05).结论 第二产程时间延长、催产素增加和胎儿体重增加是肛提肌裂孔扩张的影响因素,对预测和精确诊断盆底疾病有临床意义. 相似文献
3.
4.
提出一种改进的基于人体静电冲击模型(Human Body Model, HBM)应力的瞬态功率模型。利用HSPICE仿真软件, 模拟MOS管遭受的HBM应力, 得到对应的等效直流电压。HBM电路的预充电电压与MOS管对应的等效直流电压值的散点图表明, 两者保持线性关系, 并通过拉普拉斯变化得到证明。与现有的瞬态功率模型相比, 改进后的模型降低了在HBM应力作用下的计算复杂度, 可以更加简便地从统计学上预测MOS管栅氧击穿的发生, 给HBM冲击作用下MOS管栅氧化层可靠性的评估提供参考。 相似文献
5.
6.
Beatriz E. Nielsen Teresa Minguez Isabel Bermudez Cecilia Bouzat 《Cellular and molecular life sciences : CMLS》2018,75(13):2457-2471
The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional contribution of the β2 subunit, we generated heteromeric receptors with fixed stoichiometry by two different approaches comprising concatenated and unlinked subunits. Receptors containing up to three β2 subunits are functional. As the number of β2 subunits increases in the pentameric arrangement, the durations of channel openings and activation episodes increase progressively probably due to decreased desensitization. The prolonged activation episodes conform the kinetic signature of α7β2 and may have an impact on neuronal excitability. For activation of α7β2 receptors, an α7/α7 binding-site interface is required, thus indicating that the three β2 subunits are located consecutively in the pentameric arrangement. α7-positive allosteric modulators (PAMs) are emerging as novel therapeutic drugs. The presence of β2 in the pentamer affects neither type II PAM potentiation nor activation by an allosteric agonist whereas it impairs type I PAM potentiation. This first single-channel study provides fundamental basis required to decipher the role and function of the novel α7β2 receptor and opens doors to develop selective therapeutic drugs. 相似文献
7.
Sei Yoshida Regina Pacitto Ken Inoki Joel Swanson 《Cellular and molecular life sciences : CMLS》2018,75(7):1227-1239
The growth and proliferation of metazoan cells are driven by cellular nutrient status and by extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical signals that increase anabolic metabolism and macropinocytosis, an actin-dependent endocytic process in which relatively large volumes of extracellular solutes and nutrients are internalized and delivered efficiently into lysosomes. Macropinocytosis is prominent in many kinds of cancer cells, and supports the growth of cells transformed by oncogenic K-Ras. Growth factor receptor signaling and the overall metabolic status of the cell are coordinated in the cytoplasm by the mechanistic target-of-rapamycin complex-1 (mTORC1), which positively regulates protein synthesis and negatively regulates molecular salvage pathways such as autophagy. mTORC1 is activated by two distinct Ras-related small GTPases, Rag and Rheb, which associate with lysosomal membranes inside the cell. Rag recruits mTORC1 to the lysosomal surface where Rheb directly binds to and activates mTORC1. Rag is activated by both lysosomal luminal and cytosolic amino acids; Rheb activation requires phosphoinositide 3-kinase, Akt, and the tuberous sclerosis complex-1/2. Signals for activation of Rag and Rheb converge at the lysosomal membrane, and several lines of evidence support the idea that growth factor-dependent endocytosis facilitates amino acid transfer into the lysosome leading to the activation of Rag. This review summarizes evidence that growth factor-stimulated macropinocytosis is essential for amino acid-dependent activation of mTORC1, and that increased solute accumulation by macropinocytosis in transformed cells supports unchecked cell growth. 相似文献
8.
Xiuli Liu 《系统科学与复杂性》2018,31(6):1554-1570
The paper established a double filtering method (DFM) to visualize the skeleton industrial structure (SIS) of one economy and find its evolution rule. Different with the previous researches, this method is from a new view of industrial conjunctions combined by leading sectors to depict the industrial structure. It was proved that the leading sector selected by DFM must be key sector selected by Hirschman-Rasmussen method. Applied DFM to input-output tables of China, Japan and USA and MFA to Japan and USA, the results analysis showed that DFM could overtake the two main shortcomings of minimum flow analysis (MFA), scratch SIS of each economy with its own characteristics, visualize the general evolution rules of the industrial structure with crisscrossed conjunctions among leading sectors. 相似文献
9.
In this article we consider the growing interest in recent years in the use of documentary strategies in the wold of contemporary art, film and performing arts and explore some of the central epistemological assumptions underpinning the persistent idea that the documentary should be equated with ‘non-fiction’. Following Stella Bruzzi we argue that if documentary theory maintains objectivity as the primary measure of value, it will inevitably and continuously arrive at the conclusion that the documentary genre is fundamentally flawed. Instead, we propose to move beyond the ‘realist epistemology’ of documentary theory and focus on the ‘documentary real’, i.e. the specific performativity of the reality constructed in and by the documentary genre. In the last paragraphs, we introduce the various articles that address the “documentary real” in this special issue. 相似文献
10.
Patricio Atanes Inmaculada Ruz-Maldonado Ross Hawkes Bo Liu Min Zhao Guo Cai Huang Israa Mohammed Al-Amily Albert Salehi Stefan Amisten Shanta J. Persaud 《Cellular and molecular life sciences : CMLS》2018,75(16):3039-3050