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Dicer is essential for mouse development 总被引：33，自引：0，他引：33
Bernstein E Kim SY Carmell MA Murchison EP Alcorn H Li MZ Mills AA Elledge SJ Anderson KV Hannon GJ 《Nature genetics》2003,35(3):215-217
To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development. 相似文献
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Stuart B. Murchison 《西北部美国博物学家》2011,49(1)
A bulk sampling of gastropods collected near Great Salt Lake, Utah, Revealed several fish bones of Gila atraria (Girard). The early date of this find, coupled with the relationship of the Gilbert lake transgression and successive regression of approximately 11,000 years B.P., reveals a death assemblage induced by a series of saline inundations into the freshwater paludal environment. 相似文献
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Tam OH Aravin AA Stein P Girard A Murchison EP Cheloufi S Hodges E Anger M Sachidanandam R Schultz RM Hannon GJ 《Nature》2008,453(7194):534-538
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