基于泰勒级数展开法的船舶水动力数值预报

为减小由大、小时间参数区域划分不明确所导致的三维时域Green函数的数值误差,在大、小时间区域交界处采用泰勒级数展开法对三维时域Green函数进行计算.基于线性叠加原理,采用脉冲响应函数法对船舶辐射问题与绕射问题进行求解.将Wigley Ⅰ型船作为研究算例,数值计算结果表明:本文计算的三维时域Green函数数值精度在大、小时间参数过渡区域内提高了四个数量级,水动力数值计算结果与其他文献结果及试验结果吻合较好,证明了本文所建立的水动力分析模型的可靠性.     

产后早期肛提肌裂孔扩张程度及相关因素分析

目的 分析产后早期肛提肌裂孔扩张的影响因素.方法 盆底超声测量产后早期女性肛提肌裂孔面积,其中研究组为105名肛提肌裂孔扩张者,对照组为145名肛提肌裂孔正常者,对肛提肌裂孔扩张的相关因素进行二元Logistic回归分析.结果 研究组中盆底疾病的发生率高于对照组(P＜0.05),Logistic回归分析显示第二产程时间、胎儿体重、催产素使用和盆腔器官脱垂与肛提肌裂孔扩张显著相关(P＜0.05).结论 第二产程时间延长、催产素增加和胎儿体重增加是肛提肌裂孔扩张的影响因素,对预测和精确诊断盆底疾病有临床意义.     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

砂岩在西湖凹陷花港组交互式盖层中的作用初探

西湖凹陷花港组盖层具有砂泥岩交互式发育特征，而与泥岩伴生的砂岩类盖层的油气封闭作用研究较少。采用岩芯、镜下观察及压汞等分析方法，对砂泥岩交互式盖层中的砂岩特征进行了分析。结果表明，盖层中的砂岩可作为有效盖层，砂岩类盖层早期受沉积环境控制，含有较多的泥质而导致早期压实作用较强，加之晚期的黏土矿物转换及胶结物的发育，具备形成良好盖层的条件。在不同地区进行砂岩盖层有效性研究时应以沉积环境为基础，针对不同类型的砂岩进行成岩作用研究，并针对不同类型的砂岩样品进行实验分析以明确砂岩盖层的有效性。     

南方丝绸之路对大理的影响及当前的对策

大理历史悠久,文化灿烂,风光秀丽,古道纵横。过去南方丝绸之路对大理的经济、政治、交通、文化、宗教等有较大的影响,今天在国家"一带一路"的大战略背景下,大理应该怎么办,大理学院应该怎么办,这是当代学人的新课题。以古代南方丝绸之路为出发点,建议今天大理的"一带一路"定位为交往之路、人情之路。     

上海黄浦江两支流河流甲烷含量研究

甲烷是一种重要的温室气体,虽然目前大气中含量远小于二氧化碳,但排放增长率却大于后者.研究区域为上海市黄浦江支流苏州河和淀浦河,通过实验数据对比城郊春夏的甲烷排放的差异,探讨甲烷产生的机制及其与环境因子的关系,这将有助于研究河流甲烷排放对于环境变化的影响.研究结果认为河流甲烷主要来源于水中沉积物,其产生与水质、温度等因素相关;同时甲烷摩尔浓度与硝酸根离子质量体积比存在负相关性,与铵根离子质量体积比和有机碳质量分数存在正相关性.     

Study on the Centralization Strategy of the Blood Allocation Among Different Departments within a Hospital

By far, the researches on how to distribute blood products among different departments in hospital have not been further studied, though the problem of blood shortage and wastage that caused by improper blood allocation is severe, which may endanger patient’s lives and impose considerable costs on hospitals. In order to solve this problem, this paper mainly studies on how to distribute the blood items among different departments within a hospital and investigates the allocation approach with the novel management method by centralizing the inventory of several different departments. By integrating the blood inventory requirements of some departments, the hospital could reduce the rate of blood shortage and wastage effectively, release the pressure of the occupancy of resources and reduce the bullwhip effect of blood products. This paper illustrates the centralization principle in hospital and formulates the mixed integer programming model to work out the optimal allocation network scheme and the optimal inventory setting for every department. And the results of the numerical example demonstrate that this centralization method could considerably reduce blood shortage and wastage in hospital by about 72% and 90% respectively. Furthermore, it could decrease the total cost by about 108,540 RMB a month on blood supply chain management in the hospital and improve the effect of some certain surgeries by transfusing the fresh blood to patients.     

四-对羟基苯基卟啉的自组装及光电特性

利用X射线光电子能谱(XPS)测试5,10,15,20-四-(对羟基苯基)卟啉单体和5,10,15,20-四-(对羟基苯基)卟啉自组装二聚体,并通过化学模拟得到卟啉自组装二聚体分子的最优构象.结果表明:两种卟啉化合物中氧原子的类型不同;在单体卟啉中未检测到瞬态表面光电压信号,卟啉自组装二聚体表现出较好的瞬态表面光伏特性;卟啉自组装二聚体的光限幅性质优于卟啉1单体.     

基于稳健协方差矩阵的ADS-B压制式干扰抑制

压制式干扰是广播式自动相关监视(automatic dependent surveillance broadcast, ADS-B)系统面临的最常见且最有威胁的干扰之一。提出基于稳健协方差矩阵估计的ADS-B压制式干扰抑制算法。首先,考虑了ADS-B信号的脉冲特性,将协方差矩阵的求解转化成凸优化问题。然后,利用求解凸优化问题得到的稳健协方差矩阵设计最优权矢量。最后,对观测信号进行空域滤波,完成ADS-B的压制式干扰抑制,并对抑制结果进行性能分析。提供的仿真实验结果也验证了算法的有效性,该方法不需要知道ADS-B信号来向,且在非高斯噪声情况下同样有效。     

水溶性La_(0.88)Sr_(0.12)MnO_3纳米粒子的非水相合成

采用纳米微乳液法,以三嵌段共聚物聚氧乙烯-聚氧丙烯-聚氧乙烯(PEO-PPO-PEO)为表面活性剂,乙酰丙酮镧(III),乙酰丙酮锰(III)和乙酰丙酮锶(II)为前驱体,1,2-十六烷二醇为还原剂成功合成了水溶性La0.88Sr0.12MnO3纳米粒子.FT-IR分析证实该纳米粒子表面存在PEO-PPO-PEO分子,XRD和TEM分析表明该纳米粒子基本上呈球形、粒径分布窄、结晶度高,VSM测试表明该纳米粒子室温下显示软铁磁性.纳米粒子在水中快速和高效的分散收集过程,表明该纳米粒子具有良好的水溶性和磁操控性.