基于规则分组的DFA正则表达式匹配算法

模式匹配因误报率低和漏报率低被入侵检测所采用.在使用正则表达式构造DFA时,因状态爆炸导致匹配算法需要较多的存储空间和运行时间,算法效率低下,采用规则分组后,可以在一定程度上抑制状态爆炸问题.根据缓存中的历史记录对正则表达式进行分组,既能利用规则分组减少状态总数,抑制状态爆炸,又能减少因每次重新构建DFA所带来的开销,提高了匹配效率,有利于提高入侵检测的实时性、准确性和高效性.     

The Effectiveness of Structural Monetary Policy and Macro-Prudential Policies — Based on the DSGE Model That Includes Bank Heterogeneous Credit

Journal of Systems Science and Complexity - Structural monetary policy and macro-prudential policies are important parts of the policy system of the People’s Bank of China. By constructing a...     

科技创新、科技产业与科技金融时空耦合分析

选取我国30个省市2008～2017年的面板数据,利用科技创新、科技产业和科技金融三系统耦合协调度模型进行测算,针对各省市三系统耦合协调度进行空间相关性检验.结果显示,我国科技创新、科技产业与科技金融整体处于中度耦合协调水平,且时间上呈现出周期波动的特征,空间上呈现出"东高西低"的态势;长三角地区始终位于H-H区域,而西北地区位于L-L区域.得出如下建议,科技金融应形成支持科技发展的长效机制;地方政府应推出因地制宜的科技金融政策;中央政府应对低度耦合发展集聚的区域给予相应的优惠补贴和鼓励措施.     

Impact of the RMB Joining in the SDR Basket on Its Internationalization from the Perspective of Risk Spillover

For evaluating the influence of the Chinese renminbi(RMB) joining in the special drawing right(SDR) basket on RMB's internationalization, the authors systemically study the risk spillover networks and examine the dynamic relationship of exchange rates among the SDR currencies including the US dollar(USD), European Union euro(EUR), Japanese yen(JPY) and British pound(GBP).The empirical results demonstrate that the USD takes a dominant position and holds the biggest risk spillover to other currencies, and the RMB's inclusion to the SDR basket makes the risk spillover to get average, giving rise to the SDR currency system more stable to a certain degree. The inclusion of the RMB in the SDR not only can reduce the systematic risk of the SDR, but also has a certain impact on the international exchange rate markets. Nowadays, in front of the growing trade friction, more such researches could help to effectively deal with the currency disputes.     

Molecular function of the novel α7β2 nicotinic receptor

The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional contribution of the β2 subunit, we generated heteromeric receptors with fixed stoichiometry by two different approaches comprising concatenated and unlinked subunits. Receptors containing up to three β2 subunits are functional. As the number of β2 subunits increases in the pentameric arrangement, the durations of channel openings and activation episodes increase progressively probably due to decreased desensitization. The prolonged activation episodes conform the kinetic signature of α7β2 and may have an impact on neuronal excitability. For activation of α7β2 receptors, an α7/α7 binding-site interface is required, thus indicating that the three β2 subunits are located consecutively in the pentameric arrangement. α7-positive allosteric modulators (PAMs) are emerging as novel therapeutic drugs. The presence of β2 in the pentamer affects neither type II PAM potentiation nor activation by an allosteric agonist whereas it impairs type I PAM potentiation. This first single-channel study provides fundamental basis required to decipher the role and function of the novel α7β2 receptor and opens doors to develop selective therapeutic drugs.     

Macropinocytosis,mTORC1 and cellular growth control

The growth and proliferation of metazoan cells are driven by cellular nutrient status and by extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical signals that increase anabolic metabolism and macropinocytosis, an actin-dependent endocytic process in which relatively large volumes of extracellular solutes and nutrients are internalized and delivered efficiently into lysosomes. Macropinocytosis is prominent in many kinds of cancer cells, and supports the growth of cells transformed by oncogenic K-Ras. Growth factor receptor signaling and the overall metabolic status of the cell are coordinated in the cytoplasm by the mechanistic target-of-rapamycin complex-1 (mTORC1), which positively regulates protein synthesis and negatively regulates molecular salvage pathways such as autophagy. mTORC1 is activated by two distinct Ras-related small GTPases, Rag and Rheb, which associate with lysosomal membranes inside the cell. Rag recruits mTORC1 to the lysosomal surface where Rheb directly binds to and activates mTORC1. Rag is activated by both lysosomal luminal and cytosolic amino acids; Rheb activation requires phosphoinositide 3-kinase, Akt, and the tuberous sclerosis complex-1/2. Signals for activation of Rag and Rheb converge at the lysosomal membrane, and several lines of evidence support the idea that growth factor-dependent endocytosis facilitates amino acid transfer into the lysosome leading to the activation of Rag. This review summarizes evidence that growth factor-stimulated macropinocytosis is essential for amino acid-dependent activation of mTORC1, and that increased solute accumulation by macropinocytosis in transformed cells supports unchecked cell growth.     

Comparison of Travel Mode Choice Between Taxi and Subway Regarding Traveling Convenience

In this study, we investigate travel mode choice behavior between taxi and subway with an emphasis on the influence of traveling convenience. In the first stage, we examine the Origin-Destination(OD) points of Beijing taxi trips and compare these locations with the respective nearest subway station. Statistics reveal several interesting conclusions. First, for approximately 24.89% of all trips, no convenient subway connections exist between the OD pairs. As such, a taxi becomes the only viable choice. Second, for 80.23% of the remaining 75.11%of trips(equivalent to 60.26% of all trips), access distance from either the origin or the destination to the nearest subway station is greater than 500 meters. This phenomenon indicates that walking distance plays an important role in travel mode choice. In the second stage, we examine groups of taxi trips with similar travel distances and travel times to reveal common features. We establish a preference rule in terms of travel distance and travel time.This determines whether an individual driver will take a taxi or the subway, using a pairwise comparison-based preference regression model. Tests indicate that more than 95% of taxi trips can be correctly predicted by this preference rule. This conclusion reveals that traveling convenience dominates the travel model choice between taxi and subway. All these findings shed light on the factors that influence travel mode choice behavior.