Tumeurs mammaires et leucémies dans une nouvelle souche de souris (PS): Etude au microscope électronique

Summary In the recently isolated Mouriquand strain of mice, virus-like particles of the A and B type are abundant in mammary tumours, and fewer particles of the C type are present in leukaemic and non-leukaemic organs. In one animal all three kinds of particles have been shown. Striking cytological features of the mammary tumours are described.     

轿车车门断面设计的原则和方法

介绍了轿车车门断面设计的基本方法,探讨了控制断面的作用和设置原则．结合车门间隙、车门密封、车门运动校核及车门结构件连接等具体设计过程,分析了车门断面设计中需要考虑的控制要素,阐述了轿车车门断面设计的基本思路和程序．     

Les cellules mammotropes et somatotropes de l'antehypophyse chez la souris C3H porteuse de tumeur mammaire spontanée. Etude quantitative au microscope électronique

Summary Pituitaries of mammary tumor-bearing mice (C3H) were examined by quantitative electron microscopy. The results indicate that considerable modifications occur in mammotropic and somatotropic cells. Both types show an increase of the surface of the endoplasmic reticulum and a decrease of the volume of secretory granules (in percent of cytoplasmic volume), suggesting a heightened secretory activity of these cells during mammary carcinogenesis.

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Une partie de ce travail a fait l'objet du mémoire pour le titre d'Assistant étranger de Mlle G. G. Sotiropoulou.

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Avec la collaboration technique dévouée de Mme J. Garaudel et l'aide de l'I.N.S.E.R.M., du C.N.R.S. et de la Ligue Nationale Française contre le Cancer.     

Cloning by functional expression of a member of the glutamate receptor family

We have isolated a complementary DNA clone by screening a rat brain cDNA library for expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single protein of relative molecular mass (Mr) 99,800 which on expression in oocytes forms a functional ion channel possessing the electrophysiological and pharmacological properties of the kainate subtype of the glutamate receptor family in the mammalian central nervous system.     

Histopathological modifications following immunotherapy with P 40 in rats bearing DMBA-induced mammary carcinoma

Summary Female Sprague-Dawley rats bearing primarily-induced mammary carcinomas were treated with a new immunostimulating agent (P 40). The histopathological modifications encountered in tumors, lymph nodes, liver and spleen are described. Intratumoral injections provoke a more widespread response of the RES, and particularly a more intense reaction in the draining lymph nodes, than systemic treatment.This work was partly supported by a contract from CHU Necker Enfants Malades (Prof. J. Reynier), with the help of the Ligue Nationale Française contre le Cancer, the FEGE-FLUC and the International Society against Breast Cancer.We thank also the Ecole de Chirurgie, Paris, and the Pasteur Institute which kindly provided the immunostimulating agent P 40. The skillfull collaboration of Dr R. Villet, Mlle G. Amichot and Mme J. Garaudel is gratefully acknowledged.