Cloning by functional expression of a member of the glutamate receptor family |
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| Authors: | M Hollmann A O'Shea-Greenfield S W Rogers S Heinemann |
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| Institution: | Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037. |
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| Abstract: | We have isolated a complementary DNA clone by screening a rat brain cDNA library for expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single protein of relative molecular mass (Mr) 99,800 which on expression in oocytes forms a functional ion channel possessing the electrophysiological and pharmacological properties of the kainate subtype of the glutamate receptor family in the mammalian central nervous system. |
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