Variable Selection via Generalized SELO-Penalized Cox Regression Models

The seamless-L_0(SELO) penalty is a smooth function that very closely resembles the L_0 penalty, which has been demonstrated theoretically and practically to be effective in nonconvex penalization for variable selection. In this paper, the authors first generalize the SELO penalty to a class of penalties retaining good features of SELO, and then develop variable selection and parameter estimation in Cox models using the proposed generalized SELO(GSELO) penalized log partial likelihood(PPL) approach. The authors show that the GSELO-PPL procedure possesses the oracle property with a diverging number of predictors under certain mild, interpretable regularity conditions. The entire path of GSELO-PPL estimates can be efficiently computed through a smoothing quasi-Newton(SQN) with continuation algorithm. The authors propose a consistent modified BIC(MBIC) tuning parameter selector for GSELO-PPL, and show that under some regularity conditions, the GSELOPPL-MBIC procedure consistently identifies the true model. Simulation studies and real data analysis are conducted to evaluate the finite sample performance of the proposed method.     

土壤水分运动方程的径向基配点法

为解决一维土壤水分运动问题,结合径向基函数与配点法,提出了一种新的无网格方法———径向基配点法无网格算法,证明了解的存在性和唯一性,并通过具体的实例,将该方法与有限差分法比较,结果表明该方法具有计算精度高且易于实现的优点。     

软件能力成熟度模型及其应用

本文首先分析了软件开发过程中存在的问题,然后介绍了软件能力成熟度模型CMM(Capability Maturity Model),定义了CMM中有关概念,分析了CMM结构及每个成熟度等级,最后讨论了CMM的应用．     

一测多评法测定壮药三加皮中5个酚酸类成分的含量

为建立一种可同时测定三加皮中5种酚酸类成分（新绿原酸、绿原酸、异绿原酸B、异绿原酸A、异绿原酸C）含量的一测多评法（QAMS）,以绿原酸为内参物,采用色谱柱phenomenex C₁₈（4.6 mm×250 mm,5 μL）,以乙腈（C）-0.2%磷酸（A）为流动相进行梯度洗脱,流速1.0 mL/min,柱温30℃,检测波长325 nm。建立新绿原酸、异绿原酸B、异绿原酸A、异绿原酸C与内参物绿原酸的相对校正因子,计算待测成分的含量,与外标法（ESM）测定的结果比较,评价QAMS的可行性与准确性。结果显示,所建立的三加皮中新绿原酸、绿原酸、异绿原酸B、异绿原酸A、异绿原酸C的相对校正因子重现性良好;10个产地的三加皮中5种成分QAMS计算值与ESM实测值比较无显著差异。本研究建立的一测多评法（QAMS）可应用于三加皮中5种酚酸类成分含量测定。     

加强内涵建设 提升高专核心竞争力

内涵建设是高校永恒的主题。本文通过分析高专存在的主要问题,探讨如何通过内涵建设提升高专的核心竞争力提出了自己的一些建议。     

基于BTEC思维的《营销策划》课程项目驱动式教学应用研究

BTEC思维与项目驱动式教学模式在本质上是高度吻合的。BTEC思维对于《营销策划》课程项目驱动式教学模式具有启发意义。在分析BTEC思维的基本特点及其与项目驱动式教学关联的基础上,提出了BTEC思维下的《营销策划》课程项目驱动式教学的"一三四"模式。     

浅论和谐社会财富公平配置的方法

随着市场经济的发展,出现了社会财富分配不公和收入差距过大的问题,严重影响我国社会主义和谐社会的构建。本文提出按照市场调节初次分配、政府调节再次分配和效率与公平统一的方法配置社会财富。     

现代教育技术与智能计算机辅助教学

本文分析了现代教育技术与传统教育模式的各自特点，然后介绍了ICAI的实现原理及其在现代教育技术中利用ICM对教学的改进方案，并阐述了将计算机技术、人工智能技术与网络技术应用于教学活动中的必然性、必要性和有效性．     

Cloning and expression of HIV-1 p24 gene in insect cells by using BAC-TO-BAC system

Recombinant transposing vector pFHIV24 was constructed by cloning the HIV-1 p24 gene into the Multiple cloning site (MCS) of the transposing vector pFastBac1 in the correct orientation with respect to the polyhedrin promoter. Recombinant bacmid bHIV24 was obtained by transposing a mini-att Tn7 element from the recombinant pFHIV24 to the mini-att Tn7 attachment site on the bacmid by Tn7 transposition functions provided by the helper plasmid. Minipreparation of recombinant bacmid DNA was transfected intoSpodoptera frugiperda (Sf9) cells to get the recombinant virus. Fresh insect Sf9 cells were infected with the recombinant virus containing p24 to express the target protein. The target protein expressed was analyzed on a 15% polyacrylamide gels and then used as antigen to check HIV-1 positive serum by ELISA. Our positive result shows that the expressed p24 protein could be used as standard antigen for HIV-1 diagnosis by ELISA and other reliable diagnostic methods of HIV-1 infection. Supported by the World Bank Boan Program Mallam Nock Joshua: born in 1967, Master of Science To whom correspondence should be addressed (027-7882712-2938)     

江西省特色产业集群发展的问题与对策

特色产业集群要依托区域资源的比较优势,以特色产业链为纽带,形成具有一定竞争优势的集群体,这对区域经济的发展起到很大的促进作用。本文先从特色产业集群的含义出发,探讨了特色产业集群形成的动力机制,针对江西省在发展特色产业集群过程中面临的问题,进行深入分析,并对促进特色产业集群发展的对策进行了探讨。