一种含N低Ni经济型双相不锈钢的抗氢脆性能的研究

设计了一种新型低Ni经济型双相不锈钢，通过金相显微镜、X射线衍射仪和扫描电子显微镜对不同固溶温度处理后的试样进行表征，通过常规拉伸实验得到综合力学性能最佳的热处理温度点，并通过电化学预充氢后的慢应变速率拉伸实验探究了其氢脆敏感性能。实验表明，随着温度的升高，奥氏体体积分数明显下降，铁素体体积分数升高，氢在双相不锈钢中的扩散能力提高。在1 050 ℃下固溶处理5 min后水淬的经济型双相不锈钢（lean duplex stainless steel，LDSS）综合性能最佳，其屈服强度和抗拉强度分别为744.7 MPa和807.7 MPa，总伸长率为62%，并且该材料在不同温度都具有优异的加工硬化性能。通过对1 050 ℃热处理后的试样进行不同电流密度和时间的预充氢处理，发现其氢脆敏感性能受充氢时间影响大于充氢电流，氢原子主要在塑性变形阶段降低材料抗拉强度和伸长率，对屈服强度影响较小。     

打造新时代创新策源地——以湖北科技特派员制度为例

湖北省多年来深入推行科技特派员制度,在全国科技特派员制度推行和科技服务的伟大实践中拼搏奋进,从启动科技特派员地市试点工作,到全面开展科技特派员基层创业行动,从出台深入推行科技特派员制度实施意见,到开展湖北省科技特派员"百县千镇万人"工程实施,围绕产业链布局人才链的科技生态日臻完善.科技特派员个人、团队和法人单位点面结合,工作室与工作站交相辉映,他们立足湖北服务华中片区和秦巴山区,辐射服务全国各地,湖北科技特派员的服务足迹遍布荆楚星辰大地,谱写着新时代湖北科技特派员服务体系的新篇章.     

基于知识图谱的核电设备健康管理知识建模与分析

随着信息技术发展,设备健康数据与知识图谱技术结合为设备健康发展带来新的发展机遇,知识图谱利用其多种特异性优势,使企业系统中积累的海量设备维修数据得到有效整合利用.本文提出基于知识图谱的核电设备健康管理知识建模与分析方法,并根据实体关系模型构建维修知识图谱本体框架,同时基于核电企业实际的维修工单数据,从统计分析和关联分析两方面取得良好的实践效果.研究结果表明,知识图谱能够在设备维修知识的集成上解决传统的数据孤岛问题,同时能基于故障的可视化分析为维修人员和管理人员提供决策和知识支持.     

产后早期肛提肌裂孔扩张程度及相关因素分析

目的 分析产后早期肛提肌裂孔扩张的影响因素.方法 盆底超声测量产后早期女性肛提肌裂孔面积,其中研究组为105名肛提肌裂孔扩张者,对照组为145名肛提肌裂孔正常者,对肛提肌裂孔扩张的相关因素进行二元Logistic回归分析.结果 研究组中盆底疾病的发生率高于对照组(P＜0.05),Logistic回归分析显示第二产程时间、胎儿体重、催产素使用和盆腔器官脱垂与肛提肌裂孔扩张显著相关(P＜0.05).结论 第二产程时间延长、催产素增加和胎儿体重增加是肛提肌裂孔扩张的影响因素,对预测和精确诊断盆底疾病有临床意义.     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

时标轴上二阶Dirichlet边值问题的弱解（英文）

采用变分方法和临界点理论研究一个时标轴上二阶Dirichlet边值问题弱解的存在性.     

关于二面体群的共轭类长素图

讨论二面体群的结构问题,利用GAP软件给出二面体群D2n的共轭类长素图,并完整给出当n以及n/2分别是奇数和偶数时的共轭类长素图情况.     

A Layer-Stripping Method for 3D Near-Surface Velocity Model Building Using Seismic First-Arrival Times

In order to improve the efficiency of 3D near-surface velocity model building, we develop a layer-stripping method using seismic first-arrival times. The velocity model within a Common Mid-Point (CMP) ...     

An Economic Model-Based Matching Approach Between Buyers and Sellers Through a Broker in an Open E-Marketplace

A broker in an open e-marketplace enables buyers and sellers to do business with each other. Although a broker plays an important role in e-marketplaces, theory and guidelines for matching between buyers and sellers in multi-attribute exchanges are limited. Therefore, a challenge for a broker’s responsibility is how to maximize a buyer’s total satisfaction degree as its goals under the consideration of trade-off between a buyer’s buying quantity and price paid to a seller, and other attributes. To solve this challenge, this paper proposes an economic model-based matching approach between a buyer’s requirements and a seller’s offers. The major contributions of this paper are that (i) a broker can model a seller’s price policy as per a buyer’s buying quantity through communication between a broker and a seller; (ii) due to each buyer’s different quantity demand, a broker models a buyer’s satisfaction degree as per a buyer’s buying quantity based on communication between a broker and a buyer; and (iii) to carry out a broker’s matching processes, an objective function and a set of constraints are generated to help a broker to maximize a buyer’s total satisfaction degree. Experimental results demonstrate the good performance of the proposed approach.