坚持"四个面向",聚焦三大科创高地,早出重大标志性成果

近日,根据省委党史学习教育的统一部署要求,浙江省科技厅厅长高鹰忠,省财政厅党组成员、驻省财政厅纪检监察组组长徐首红带领社发处、机关党委相关负责人赴天台县开展"三为"专题实践活动,实地调研浙江圣达生物药业股份有限公司、浙江天皇药业有限公司,详细了解企业创新发展面临的困难与需求,共商加快科技创新的思路举措.台州市、天台县相关同志参加调研和座谈.     

新疆旅游关注度的时空差异及其影响因素

基于百度指数平台,获取了2011年、2013年及2015年我国大陆31个省、直辖市和自治区的新疆旅游搜索指数.运用季节集中指数、周内分布偏度指数、空间自相关方法对新疆旅游关注度的时空差异进行了分析并引入GWR模型探究其影响因素.结果表明:(1)新疆旅游关注度总体呈现增长态势,且各年关注度表现出明显的季节性特征,节假日、周存在"前兆效应";(2)全国各省、直辖市和自治区的新疆旅游关注度具有显著的空间自相关性,大多数地区呈现出持续的"低—低"集聚现象;(3)GWR模型优于OLS模型,从全域视角看,人口规模、经济发展水平、教育发展水平及互联网发展水平对新疆旅游关注度的影响均呈现不同程度的正向作用;从局域视角看,各影响因素作用整体上与OLS模型结果一致,但各影响因素的敏感度在空间上表现出西部地区高于东部地区的态势.     

全自动高清智能录播教室建设研究——以福建卫生职业技术学院为例

结合福建卫生职业技术学院建设全自动高清智能录播教室实践,研究和总结在录播教室室内装修需注意的问题及解决措施,并对录播教室需要配备的多媒体教学设备、视音频信息采集、师生的跟踪定位、录播导播等提出建议。     

有限群的π′－闭性

将Ｅｎｇｅｌ条件进行了推广，利用（ｐ，ｑ）－子群的性质，得到了有限群为π′－闭的几个重要结果。     

森林生物技术走出实验室举步艰难

新的、高密度树木种植正在给林业生物技术带来迅速的变化。但是如果不能克服生态风险和经济障碍．这些新的方法或许永远也无法使用——     

电磁场的生物效应

本书是一本关于电磁场生物效应的新著。电磁场可以对各种生物产生影响，包括低频率和高频率及不同强度的电磁场的作用，因此，电磁场的研究和技术应用及环境作用等方面都十分重要。本书的内容很广泛，涉及电磁场的机理、模型化、生物效应、治疗效应、国际标准、照射判别准则等。     

The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast

The autosomal recessive disorder Shwachman-Diamond syndrome, characterized by bone marrow failure and leukemia predisposition, is caused by deficiency of the highly conserved Shwachman-Bodian-Diamond syndrome (SBDS) protein. Here, we identify the function of the yeast SBDS ortholog Sdo1, showing that it is critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes. Using genome-wide synthetic genetic array mapping, we identified multiple TIF6 gain-of-function alleles that suppressed the pre-60S nuclear export defects and cytoplasmic mislocalization of Tif6 observed in sdo1Delta cells. Sdo1 appears to function within a pathway containing elongation factor-like 1, and together they control translational activation of ribosomes. Thus, our data link defective late 60S ribosomal subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition.     

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

Resequencing genes provides the opportunity to assess the full spectrum of variants that influence complex traits. Here we report the first application of resequencing to a large population (n = 3,551) to examine the role of the adipokine ANGPTL4 in lipid metabolism. Nonsynonymous variants in ANGPTL4 were more prevalent in individuals with triglyceride levels in the lowest quartile than in individuals with levels in the highest quartile (P = 0.016). One variant (E40K), present in approximately 3% of European Americans, was associated with significantly lower plasma levels of triglyceride and higher levels of high-density lipoprotein cholesterol in European Americans from the Atherosclerosis Risk in Communities Study and in Danes from the Copenhagen City Heart Study. The ratio of nonsynonymous to synonymous variants was higher in European Americans than in African Americans (4:1 versus 1.3:1), suggesting population-specific relaxation of purifying selection. Thus, resequencing of ANGPTL4 in a multiethnic population allowed analysis of the phenotypic effects of both rare and common variants while taking advantage of genetic variation arising from ethnic differences in population history.