Comparative genomics of the neglected human malaria parasite Plasmodium vivax

The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.     

Specific and non-specific immunoglobulin synthesis in germfree mice immunized with ferritin by different routes

Résumé Après injection de ferritine de cheval, des souris C₂H axéniques développèrent des anticorps circulants ainsi que des immunoglobulines sans affinité pour l'antigène dans chacune des classes: IgA, IgM, IgG₁, et IgG₂. Après immunisation orale, la réponse spécifique fut exclusivement du type IgA, et la réponse non-spécifique principalement du type IgG₂ et IgA.

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Belgian American Educational Foundation Fellow.

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Staff Member of the Biology Division of Euratom, Euratom Publication No. 486.

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The Rega Institute for Medical Research, Louvain.     

一类非线性系统的稳定性

研究了一类非线性系统的输入输出稳定性问题，这类系统的特点是其模型为系统输出的线性拟函数。对非线性稳定性系统，利用稳定性的线性等价原理，提出了这一类非线性系统的稳定性判据；对非线性随机系统，给出了m阶均值意义下的稳定性定义，提出了一种二阶均值下的输入输出稳定性条件，给出了几个示例说明。