排序方式: 共有4条查询结果,搜索用时 140 毫秒
1
1.
Carlton JM Adams JH Silva JC Bidwell SL Lorenzi H Caler E Crabtree J Angiuoli SV Merino EF Amedeo P Cheng Q Coulson RM Crabb BS Del Portillo HA Essien K Feldblyum TV Fernandez-Becerra C Gilson PR Gueye AH Guo X Kang'a S Kooij TW Korsinczky M Meyer EV Nene V Paulsen I White O Ralph SA Ren Q Sargeant TJ Salzberg SL Stoeckert CJ Sullivan SA Yamamoto MM Hoffman SL Wortman JR Gardner MJ Galinski MR Barnwell JW Fraser-Liggett CM 《Nature》2008,455(7214):757-763
The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species. 相似文献
2.
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus 总被引:1,自引:0,他引:1
Nierman WC Pain A Anderson MJ Wortman JR Kim HS Arroyo J Berriman M Abe K Archer DB Bermejo C Bennett J Bowyer P Chen D Collins M Coulsen R Davies R Dyer PS Farman M Fedorova N Fedorova N Feldblyum TV Fischer R Fosker N Fraser A García JL García MJ Goble A Goldman GH Gomi K Griffith-Jones S Gwilliam R Haas B Haas H Harris D Horiuchi H Huang J Humphray S Jiménez J Keller N Khouri H Kitamoto K Kobayashi T Konzack S Kulkarni R Kumagai T Lafon A Lafton A Latgé JP Li W Lord A Lu C Majoros WH May GS 《Nature》2005,438(7071):1151-1156
Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A. fumigatus is isolated from human habitats and vegetable compost heaps. In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref. 2). The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis. Although the burden of invasive disease caused by A. fumigatus is substantial, the basic biology of the organism is mostly obscure. Here we show the complete 29.4-megabase genome sequence of the clinical isolate Af293, which consists of eight chromosomes containing 9,926 predicted genes. Microarray analysis revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus. 相似文献
3.
Galagan JE Calvo SE Cuomo C Ma LJ Wortman JR Batzoglou S Lee SI Baştürkmen M Spevak CC Clutterbuck J Kapitonov V Jurka J Scazzocchio C Farman M Butler J Purcell S Harris S Braus GH Draht O Busch S D'Enfert C Bouchier C Goldman GH Bell-Pedersen D Griffiths-Jones S Doonan JH Yu J Vienken K Pain A Freitag M Selker EU Archer DB Peñalva MA Oakley BR Momany M Tanaka T Kumagai T Asai K Machida M Nierman WC Denning DW Caddick M Hynes M Paoletti M Fischer R Miller B Dyer P Sachs MS Osmani SA Birren BW 《Nature》2005,438(7071):1105-1115
The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake, miso and soy sauce. Our analysis of genome structure provided a quantitative evaluation of forces driving long-term eukaryotic genome evolution. It also led to an experimentally validated model of mating-type locus evolution, suggesting the potential for sexual reproduction in A. fumigatus and A. oryzae. Our analysis of sequence conservation revealed over 5,000 non-coding regions actively conserved across all three species. Within these regions, we identified potential functional elements including a previously uncharacterized TPP riboswitch and motifs suggesting regulation in filamentous fungi by Puf family genes. We further obtained comparative and experimental evidence indicating widespread translational regulation by upstream open reading frames. These results enhance our understanding of these widely studied fungi as well as provide new insight into eukaryotic genome evolution and gene regulation. 相似文献
4.
1