PLGA组织工程支架的构建及降解行为研究

用本体开环聚合方式合成不同摩尔比的PLGA（n(dl-LA)n(GA)分别为85／15，75／25，65／35，55／45)共聚物。^H NMR和溶解试验结果表明，共聚物各链段呈无规分布，GA序列长度在1.3-1.8之间。通过溶液浇铸造-低热模压-粒子沥滤技术构建了高度多孔的PLGA组织工程支架，考察了它们在Na2HPO4-NaH2PO4缓冲溶液中的降解行为。结果表明：随着水解的进行，PLGA的特性粘度及构建的多孔支架的压缩强度迅速下降，共聚物中GA组分含量赵大，下降的速度越快，与之对应的多孔支架的多孔结构形态保持时间也随共聚物中GA组合分含量增加而下降，分别为8周（n(dl-LA)/n(GA)分别为85/15和75/25）、4周（n(dl-LA)/n(GA)为65/35）和2周（n(dl-LA)/n(GA)为55/45）；但质量损失速率比[η下降速度慢得多，多孔支架的降解速率慢于薄膜的降解速率。     

秦淮河水质改善现场调水试验

为了探究不同水闸调度方案对秦淮河水质改善的效果,进行了洪水期、丰水期调度、枯水期调度和降雨初期雨水污染调度等典型时段调水试验。结果表明:通过合理调控闸泵可对秦淮河水质产生积极效果,上游来水、引水的质量和调度时段对于调度效果具有明显影响。     

Gene polymorphism in Netherton and common atopic disease.

Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions, including the chromosome 5q31 cytokine cluster. Netherton disease is a rare recessive skin disorder in which atopy is a universal accompaniment. The gene underlying Netherton disease (SPINK5) encodes a 15-domain serine proteinase inhibitor (LEKTI) which is expressed in epithelial and mucosal surfaces and in the thymus. We have identified six coding polymorphisms in SPINK5 (Table 1) and found that a Glu420-->Lys variant shows significant association with atopy and AD in two independent panels of families. Our results implicate a previously unrecognized pathway for the development of common allergic illnesses.     

液固流化床粗煤泥分选机理与应用研究

粗煤泥分选问题成为影响精煤产率提高的主要瓶颈.液固流化床分选机的分选原理能够吻合粗煤泥本身的粒度范围窄、需要低密度分选的特点,是一种结构简单、分选效果较好的新技术.本文分析了我国粗煤泥分选的现状及存在的问题,指出TBS干扰床分选机处理粗煤泥的优势.阐述了颗粒特性、流体性质等对分选效果的影响,提出了在试验过程中加大对上升...     

一类关联时滞广义大系统的稳定性与分散镇定

该文研究了一类关联时滞广义大系统的稳定性和分散镇定问题，目的是设计一状态反馈分散控制器，使得闭环系统正则、脉冲自由且稳定。应用线性矩阵不等式方法，给出了该类关联时滞广义大系统的稳定性与分散镇定的充分条件。它们是一组严格的线性矩阵不等式。当这组条件可解时，给出了分散状态反馈控制器的严格线性矩阵不等式设计方法和控制律的表达式。最后给出算例仿真说明所给方法的应用。     

The avian nature of the brain and inner ear of Archaeopteryx

Archaeopteryx, the earliest known flying bird (avialan) from the Late Jurassic period, exhibits many shared primitive characters with more basal coelurosaurian dinosaurs (the clade including all theropods more bird-like than Allosaurus), such as teeth, a long bony tail and pinnate feathers. However, Archaeopteryx possessed asymmetrical flight feathers on its wings and tail, together with a wing feather arrangement shared with modern birds. This suggests some degree of powered flight capability but, until now, little was understood about the extent to which its brain and special senses were adapted for flight. We investigated this problem by computed tomography scanning and three-dimensional reconstruction of the braincase of the London specimen of Archaeopteryx. Here we show the reconstruction of the braincase from which we derived endocasts of the brain and inner ear. These suggest that Archaeopteryx closely resembled modern birds in the dominance of the sense of vision and in the possession of expanded auditory and spatial sensory perception in the ear. We conclude that Archaeopteryx had acquired the derived neurological and structural adaptations necessary for flight. An enlarged forebrain suggests that it had also developed enhanced somatosensory integration with these special senses demanded by a lifestyle involving flying ability.     

Genome-wide genetic association of complex traits in heterogeneous stock mice

Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress in the molecular dissection of complex traits in mice. Here we show that genome-wide high-resolution mapping of multiple phenotypes can be achieved using a stock of genetically heterogeneous mice. We developed a conservative and robust bootstrap analysis to map 843 QTLs with an average 95% confidence interval of 2.8 Mb. The QTLs contribute to variation in 97 traits, including models of human disease (asthma, type 2 diabetes mellitus, obesity and anxiety) as well as immunological, biochemical and hematological phenotypes. The genetic architecture of almost all phenotypes was complex, with many loci each contributing a small proportion to the total variance. Our data set, freely available at http://gscan.well.ox.ac.uk, provides an entry point to the functional characterization of genes involved in many complex traits.     

广义系统的非脆弱观测器设计与镇定控制

为了进一步提高控制器的适应能力,该文研究了基于观测器的广义系统非脆弱控制问题.针对控制器和观测器不确定性都是时不变且有界的情况,应用线性矩阵不等式( Linear matrix inequalities,LMI)方法给出了非脆弱观测器存在条件,应用广义代数Riceati不等式(Generalized algebraic Riccati inequalities,GARI)方法解决了基于观测器的广义系统非脆弱控制问题;给出了非脆弱控制器和非脆弱观测器的参数表达式.数值仿真结果验证了所给方法的有效性和应用.     

浅析环渤海港口群的经济运行情况及对策

环渤海港口群,是我国北方最大的港口群,发展相对落后于长江三角洲港口群,珠江三角洲港口群。与这两个港口群相比,环渤海经济区内的国有经济比重较大,行政干预经济发展的力量比较强,市场力量决定资源配置还相对较弱。因此,如何充分发挥环渤海港口群的整体优势,立足于国内国际航运发展形势,改变其当前的不利处境,推动区域经济,的可持续发展是我们面临的重要课题。