基于网络药理学和分子对接探讨智脑胶囊改善阿尔茨海默病的作用机制

借助网络药理学和分子对接技术,探讨智脑胶囊改善阿尔茨海默病的干预机制。通过TCMSP、TCMID等多个数据库寻找与智脑胶囊相关的化学成分及其作用靶点;利用GeneCard等数据库获取阿尔茨海默病的作用靶点;运用Venny2.1网站筛选出药物与疾病的交集靶点;使用STRING平台和Cytoscape软件进行拓扑分析得到智脑胶囊治疗阿尔茨海默病的核心作用靶点;采用Metaspace数据库对潜在核心作用靶点进行GO(gene ontology)及KEGG(Kyoto encyclopedia of genes and genomes)通路富集分析;利用AutoDock软件使用分子对接验证活性化合物与核心靶点的结合能力。结果表明：在智脑胶囊中共筛选出44个活性成分和292个有效靶点,智脑胶囊与阿尔茨海默病共同靶点58个;蛋白质-蛋白质相互作用得出关键靶点包括AKT1、IL-6、TNF等;GO分析共包含1 419条,KEGG得到175条代谢通路,主要包括脂质与动脉硬化、TNF信号通路;分子对接显示关键成分与靶点具有良好的结合能力。研究表示智脑胶囊可能通过脂质与动脉硬化和TNF信号通路等途径来减轻...     

一种新的模糊决策树算法 ——基于加权毕达哥拉斯模糊熵

传统的模糊决策树虽然可以从模糊数据中抽取模糊分类规则,但只能获取节点的隶属度信息,无法得出样本数据对于节点的非隶属度和犹豫度信息,导致数据分类的准确率不高。针对此,基于毕达哥拉斯模糊集理论,提出了一种新的加权毕达哥拉斯模糊决策树算法（Weighted Pythagorean Fuzzy Decision Tree,WPFDT）。首先,通过改进的K-means聚类算法得到连续属性数据的聚类中心,并结合三角模糊数对连续数据进行模糊处理;其次,定义并计算每一个属性的加权毕达哥拉斯模糊熵,选择加权毕达哥拉斯模糊熵最小的属性作为决策树根节点,在根节点下递归选择模糊熵最小的属性作为分裂节点,同时通过阈值控制树的规模,得到从根节点到叶子节点路径的模糊规则以及模糊规则的隶属度、非隶属度以及犹豫度,并完成预测分类,直至生成WPFDT模型;最后,选取UCI上的3个医学数据集（Haberman、Breast Cancer、Parkinson）进行实验,在分类准确率和得出模糊规则的数量与3种传统决策树算法（模糊ID3算法、C4.5算法、CART算法）比较,实验结果表明：WPFDT在分类精度和树大小上都优于其他传统决策树算法,并且有较高的召回率和精确率。     

Lattice distortion of nanoscale silver particles

The lattice distortion of nanoscale silver particles prepared is studied by using the chemical method. The particles lattice contract was found, and the lattice contraction become greater while the particle size decreases. The results were explained with surface energy and surface tension.     

Preparation of InSb nanocrystals embedded in SiO2 thin films

InSb nanocrystals embedded in SiO₂ thin films were prepared by rf magnetron cosputtering technique. THe observation by transmission electron microscope showed that InSb nanocrystals dispersed uniformly in SiO₂ matrices. InSb nanocrystals with different sizes can be obtained by changing the annealing condition. The average size of InSb nanocrystals depended on annealing temperature and time, but not on the t_1/3 rules. X-ray photoelectron spectroscopy and X-ray diffraction were also applied to the analyses of the composite thin films.     

数字在屏幕显示控制核的设计与FPGA实现

设计了一种数字在屏幕显示(On Screen Display,OSD)控制核,在水平和垂直扫描信号同步下,根据用户软件设置字符及位图的显示属性,合成OSD图像数据,与输入视频叠加显示.利用现场可编程门阵列(Fied Programmable Gate Array,FPGA)进行验证和性能测试,并通过温度实验,工作稳定可靠.将其应用于一款军用液晶显示器(Liquid Crystal Display,LCD),解决了实际问题.该OSD控制核的特点在于把基于字符和位图的两种OSD图像生成方法融合在一起,功能得到增强,生成了图文信息丰富的OSD图像,串、并行两种用户接口提高了系统兼容性.     

Development of the CAS-IBB single-particle microbeam for localized irradiation of living cells

A single-particle microbeam facility has been constructed at the Key Laboratory of Ion Beam Bioengineering (LIBB), Chinese Academy of Sciences (CAS). The system was designed to deliver a defined numbers of hydrogen ions, produced by a van de Graaff accelerator, in an energy range of 2.0-3.0 MeV, into an area smaller than that of the nucleus of an individual living cell. The beam is collimated by a borosilicate glass capillary that forms the beam-line exit. An integrated computer program recognizes the cells and locates them one by one over the microbeam exit for irradiation. We present technical details of the CAS-LIBB microbeam facility, particularly on the collimator, hardware, control program, as well as cell irradiation protocols available. Various factors contributing to the targeting and positioning precision are discussed along with accuracy measurement results.