Combretastatin B-1的化学合成及结构衍生化研究

近来,Combretastatin B-1（CB1）由于在抗肿瘤活性尤其在靶向恶性肿瘤血管的选择性方面引起了医学界广泛关注.该化合物提取自药用植物Combretum caffrum,其抑制肿瘤细胞生长,抑制血管生成和微管蛋白聚合方面的应用前景激发了人们对CB1化学合成的极大兴趣.CB1及其衍生物是一类具有广泛生物活性和良好应用前景的化合物,因此CB1的化学合成及结构衍生化研究显得极为重要.     

基于 Web Services的MIS结构研究与应用

针对基于传统C/S(C lient/Server)结构的管理信息系统(M IS:M anagem ent Inform ation System s)已经不能满足当前的需求,并且当前流行的B/S(B rowser/Server)和B/C/S(B rowser/C lient/Server)结构等也存在着很多的不足,研究了基于W eb Services的M IS结构,讨论了该结构的特点和实现,并在此基础上以“某省学位管理信息系统”为例,讨论了系统的开发方法。该结构可以解决当前M IS结构的不足,该设计思想也可以应用于其他系统的结构设计中。     

固体酸催化合成环已酮1,2-丙二醇缩酮进展

评述了对甲苯磺酸、氨基磺酸、强酸性阳离子交换树脂、六水三氯化铁、二水氯化亚锡、硫酸铜、水合硫酸铁、十二水合硫酸铁铵、硫酸钛、四水硫酸铈、铌酸、树脂固载Lewis酸、一水硫酸氢钠、碘、固体超强酸、杂多酸、分子筛和维生素C等催化剂催化合成环已酮1,2-丙二醇缩酮的实验结果.建议对近年来开发的有应用前景的催化剂进行扩大试验与筛选.     

Synthesis of novel superhard materials under ultrahigh pressure

Superhard materials are solids whose Vickers hardness is beyond 40 GPa. They have wide applications in industry such as cutting and polishing tools, wear-resistant coatings. Most preparations of superhard materials are conducted under extreme pressure and temperature conditions, not only for scientific investigations, but also for the practical applications. In this paper, we would introduce the recent progress on the design and preparations of novel superhard materials, mainly on nanopolycrystalline diamond, B–C–N superhard solid solutions, and cubic-Si3N4/diamond nanocomposites prepared under ultrahigh pressure and high temperature（HPHT）, using multi-anvil apparatus based on the hinged-type cubic press. Bulk materials of all these superhard phases have been successfully synthesized and are systematically tested. We emphasize that ultra-HPHT method plays an important role in the scientific research and industrial production of superhard materials. It provides the driving forces for the light elements forming novel superhard phases as well as the way for sintering high-density nanosuperhard materials.     

MiR-205 inhibits the invasion and migration of esophageal squamous cell carcinoma by modulating SMAD1 expression

Esophageal squamous cell carcinoma （ESCC） is one of the most lethal cancers worldwide. In this study, we aimed to investigate the underlying mechanisms of metastasis inhibition by miR-205 in ESCC. In microRNA （miRNA） array and quantitative RT-PCR analyses, we found that the expression level of miR-205 was significantly lower in patients with lymph node metastasis compared with that in patients without lymph node metastasis. After transfection of miR-205 mimics or inhibitors into ESCC cell lines, a significant negative correlation was observed between the expression level of miR-205 and Smad 1. In luciferase reporter assays, we revealed that miR- 205 inhibited the expression of SMAD1 by targeting the 3＇ untranslated region （3＇-UTR） of SMAD1 mRNA in ESCC cells. Furthermore, our results showed that miR-205 sup- pressed the invasion and migration of ESCC cells, whereas Smadl increased their invasion and migration. Taken together, our study demonstrates that miR-205 functions as a suppressor of tumor metastasis by regulating SMAD1 expression through targeting the 3＇-UTR of SMAD1 mRNAin ESCC. Therefore, miR-205 may be a potential therapeutic target for miRNA-based therapy of ESCC.     

DanHong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice

Clinical observations indicate that DanHong Injection （DHI） can increase blood flow and reduce various syndromes in patients with cardiovascular disease. How- ever, it still needs to define the function of DHI and the involved mechanisms in details, such as the protective effect on the development of primary abdominal aortic aneurysms （AAAs）. In this study, we determined whether DHI is able to inhibit AAA in apoE knockout （apoE-/-） mice. Thirty apoE-/- male mice on high-fat diet （0.5 % cholesterol, 21% fat） were randomly divided into two groups and received i.p. injection of saline （100 μL/day） and DHI （100 μL/day）, respectively, for 16 weeks. At the end of experiment, we determined the development of atherosclerosis in en face aorta and aneurysms,pathological morphology of arterial wall, and serum lipid levels. We also determined the expression of monocyte chemoattractant protein-1 （MCP-1）, MMP-2, and MMP-9 mRNA in aortic wall using real-time RT-PCR. Our results indicated that high-fat diet induced the development of AAAs in apoE-/- mice, but the induction was totally blocked by DHI （P 〈 0.01）. The result of staining of abdominal aortic cross sections showed that DHI main- tained the collagen content in arterial wall, thereby pre- venting the animals from the development of AAA. Although DHI had little effect on serum total- and LDL- cholesterol levels, it reduced the expression of MCP-1, MMP-2, and MMP-9 mRNA in aortic wall （P 〈 0.01）. Taken together, our study suggests that DHI can inhibit the high-fat diet-induced AAA formation. The inhibitory effects may be related to the maintenance of the collagen content and inhibition of expression of AAA-related genes. Our study may suggest a new application of DHI in clinics.     

Description of rotational properties of the superheavy nucleus ^256,258,260Rf by projected shell model

Band structure of the Z = 104 nucleus 256Rf has been a recent research focus in nuclear physics. We performed projected shell model calculations for this and some other neighboring Rf isotopes. Specifically, we studied rotational properties of these nuclei and showed that variations in dynamic moment of inertia were sensitive to single-particle structures, which may be useful information for locating the anticipated island of stability. Electromagnetic transition properties were also calculated, and measurable quantities were predicted for further experimental test.     

基于l1范数主成分分析的极化SAR图像变化检测

为提高极化合成孔径雷达(synthetic aperture radar, SAR)图像变化检测算法的鲁棒性以及检测精度,提出基于范数主成分分析(linorm principal component analysis,l1-PCA)模型的变化检测算法。首先,采用基于Hotelling-Lawley复矩阵迹变化检测算子构造差异图;其次,采用l1-PCA模型获取差异图的变化信息,使得每个像素以一个特征向量来表示;最后,使用k-means算法对变化信息进行聚类,得到变化检测结果。该方法是一种非监督变化检测方法,相比于基于2范数的PCA检测方法,l1-PCA在特征提取方面具有更高的鲁棒性,并且可以进一步提高变化检测精度。基于RADARSAT-2卫星获取的3幅图像进行的实验结果表明,相较于其他两种典型算法,所提算法更加稳定,精确度更高。     

Molecular and morphological identification of two new African species of Dugesia (Platyhelminthes,Tricladida, Dugesiidae) from Cameroon

The paper describes two new Dugesia species collected from the rivers Messassi and Ntsetsensooh in Cameroon, representing the first planarian flatworms documented from this country. Based on morphological data, the new species Dugesia bijuga Harrath & Sluys, sp. nov. is characterized mainly by the presence of two diaphragms, a barrel-shaped penis that is traversed by numerous ducts of penis glands and is provided with a short nozzle, and the presence of two atrial folds. The other new species, Dugesia pustulata Harrath & Sluys, sp. nov., is characterized mainly by absence of a penis bulb, presence of a large, elongated and weakly muscular seminal vesicle, and by the ventroposterior section of the bursal canal being thrown into distinct folds. The phylogenetic position of the two new species was determined through a molecular phylogenetic tree, based on a mitochondrial and a nuclear gene, including species from the major geographical range of distribution of the genus Dugesia. The phylogenetic tree revealed that the Cameroon lineage does not constitute a monophyletic group with the other Afrotropical species; it also showed that the African continent may house a great diversity of Dugesia species that still remains to be discovered.

urn:lsid:zoobank.org:pub:007441A5-F037-4950-9F5B-AD6ED12A40ED     

利用探空秒数据估算北京地区日最大混合层高度

研究利用北京地区L波段探空秒数据和地面日最大位温, 采用气块法反演北京地区日最大混合层高度(MMH)的可行性。将08时探空秒数据以及常规探空数据反演结果分别与对应的微脉冲激光雷达反演结果相比较, 发现前者与激光雷达反演结果的一致性好于后者, 常规探空数据垂直空间分辨率低可能是导致其反演结果误差较大的原因。分别用春夏秋冬的探空秒数据反演结果与激光雷达反演结果相比较, 发现春夏秋反演结果的一致性较好, 而冬季较差。利用08时探空秒数据结合地面日最大位温, 采用气块法反演北京地区2010—2017年的MMH, 发现MMH 每年均表现出春夏秋冬逐次递减的分布特征。通过对长期资料的统计分析发现, 北京地区日地面最高气温与850 hPa温度差定义的热力稳定度与MMH之间存在较强的正相关性。