~(131)I标记抗人结肠癌单克隆抗体MC_3对裸鼠载人肠癌的放射免疫显像和导向治疗研究

用~(131)I标记的抗人结肠癌单克隆抗体(McAbMC_3)对裸鼠载人肠癌进行放射免疫显像诊断和实验性治疗研究。结果显示:体外标记抗体特异性结合率分别为37.5％和32.1％。裸鼠体内在48~120h的ECT照相可见在肿瘤部位均有放射性的特异性浓聚,其摄取量随时间延长逐渐增加,肿瘤显影清晰,显像的合适时间为96～120h。而给予非特异性的~(131)I-NMIgG后肿瘤部位来见放射性浓聚,而呈全身均匀性分布。120h肿瘤组织与肝脏及正常肠组织的比值分别为3.61和9.81,肿瘤定位指数为4.26。实验治疗显示与对照相比~(131)I-MC_3对肿瘤有明显的抑制生长作用,治疗后第14天肿瘤抑制率为90.14％,与~(131)I-NMIgG对照组比较差异极显著(P<0.01)。治疗后第32天裸鼠血清CEA含量与~(131)I-NMIgG组比较差异显著(P<0.05)。病理组织学检查结果显示治疗后8天注射~(131)I-MC_3裸鼠肿瘤呈大片坏死,仅局部肿瘤边缘尚存少数完整的肿瘤细胞,而其它正常组织、器官未见明显辐射损伤。提示McAbMC_3用于肠癌的诊断和导向治疗可能有良好的前景。     

成层软粘土地基非线性流变固结理论研究

研究了具有非线性流变特性的成层地基一维固结问题,并考虑了土的自重、渗透性变化和变荷载。基于多层地基一维线弹性固结解析解和迭代法,建立了求解该复杂问题的半解析算法,并编制了相应的计算程序AODNRCLS;此工作使固结理论更趋完善。     

One-Class Support Vector Machine with Relative Comparisons

One-class support vector machines (one-class SVMs) are powerful tools that are widely used in many applications. This paper describes a semi-supervised one-class SVM that uses supervision in terms of relative comparisons. The analysis uses a hypersphere version of one-class SVMs with a penalty term appended to the objective function. The method simultaneously finds the minimum sphere in the feature space that encloses most of the target points and considers the relative comparisons. The result is a standard...     

经济决策的神经化学与遗传基础

神经成像技术的快速发展, 使得经济决策研究进入了一个新阶段, 即在行为决策科学、行为经济学的基础上, 借鉴自然科学的研究手段与方法开展跨学科领域的探索, 神经经济学在本世纪诞生并迅猛发展. 随着该交叉学科研究的进一步深入, 遗传学、基因组学等更多自然科学学科也开始与经济决策研究结合, 使得研究者从个体的微观视角对经济决策的理论与观点进行更为深入地理解和阐释. 最新的研究表明, 大脑内的神经递质与人们的包括经济决策在内的决策紧密相关, 而决定大脑神经递质的遗传基因又通过影响神经递质的水平与功能, 间接地影响人们的决策行为. 本文以神经递质多巴胺、5-羟色胺、催产素为例, 着重介绍大脑内的3种神经递质及其对应的相关基因与人们经济决策中风险决策、社会决策的密切联系与内在机理.     

Clapping and Broadcasting Synchronization in Wireless Sensor Networks

The Clapping and Broadcasting Synchronization (CBS) algorithm,which is specifically designed for large-scale sensor networks with low communication overhead and high synchronization accuracy,is introduced.The CBS protocol uses broadcasting rather than pairwise communication to accomplish synchronization.In the CBS scheme,the initial offset of local clocks can be successfully eliminated by the operation of clapping nodes,which leads to significant improvement in synchronization accuracy.The CBS protocol was implemented on the TelosB platform and its performance was evaluated in a variety of experiments.The results demonstrate that the CBS protocol outperforms the current state-of-the-art approach,the Flooding Time Synchronization Protocol (FTSP),in both single-hop and multi-hop scenarios in terms of synchronous precision and energy consumption.In multi-hop scenarios,the CBS algorithm keeps about 50% of its synchronization errors within 1 ms.In comparison,the FTSP keeps less than 7% of its synchronization errors within this range.In both single-hop and multi-hop scenarios,the CBS protocol is over 3.2 times more energy-efficient than the FTSP.     

Controlling the probability density of quantum systems

A new method to design a quantum controller which directly controls the probability density function(PDF) of quantum systems is proposed.Based on the quantum model from the PDF perspective,two specific control algorithms are proposed with uniform and non-uniform fields,respectively.Then a detailed control algorithm with convergence analysis is given for the small error case.By appropriately estimating the selected Lyapunov function,more accurate control effect is achieved.The proposed scheme provides a constructive method to find appropriate parameters for controller design.     

Modeling large reversible electric-field-induced strain in ferroelectric materials using 90° orientation switching

Reversible large electric-field-induced strain caused by reversible orientation switchings in BaTiO3 is modeled using the Landau's theory of phase transition.A triple well free energy function is constructed.Each of its minima is associated with one of the polarization orientations involved.Nonlinear constitutive laws accounting for reversible orientation switchings and electrostriction effects are obtained by using thermodynamic equilibrium conditions.Hysteretic dynamics of onedimensional structures is des...     

Equilibrium equations for nonlinear buckling analysis of drill-strings in 3D curved well-bores

With the development of drilling technology,the oil/gas well has evolved from its early vertical straight form to the inclined,horizontal,plane curved,or even 3D curved well-bore.Understanding of the buckling behavior of a drill-string in a well-bore is crucial for the success of a drilling operation.Therefore,equilibrium equations for analyzing the buckling behavior of a drill-string in a 3D curved well-bore are required.Based on Love's equilibrium equations for a curved and twisted rod in space,a set of e...     

A New Network Planning Method Based on the Connection Number a bi of SPA

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