Ⅰ-65增强柔红霉素抗癌活性的研究

采用体外细胞培养技术,观察了钙离子阻断剂3、6-[=甲氨基]-=苯骈碘杂六环枸橼酸盐(I-65)单独和与柔红霉素(DNR)合用对L_(1210)细胞增殖的影响。结果:单独应用I-65时对细胞的增殖和集落形成抑制作用极小;与DNR合用,可显著增强DNR对细胞增殖的抑制作用。其ID_(50)为单用DNR的1/11。联合用药时细胞集落形成率较单用DNR(0.15μg/ml)下降14倍,证实I-65能显著增强DNR的抗癌活性,为广泛应用DNR,减轻心脏毒性,防止耐药提供新手段,为临床提供了一种新的抗癌药物增效剂。     

Molecular fossils and oil-source rock correlations in Tarim Basin, NW China

The distribution of "molecular fossils" (bio-markers) of steroid compounds in extracts from some spe-cific geologic age in the Tarim Basin have been analyzed andare used as the fingerprints for the oil-source rock correla-tion. Having been affected by maturation, migration, phasefractionation and biodegradation, not any molecular fossilsrelated to source and environment can be used as the finger-prints for oil-source rock correlation. Some special bio-markers widely existed in the extracts from Cambrian andOrdovician rocks in the Tarim Basin and showed obviousdifference in each stratum, including dinosteranes (C₃₀),4-methyl-24-ethyl-cholestanes (C₃₀) and their aromatizedsteroids, C₂₄-norcholestanes and C₂₈ steranes originated fromdinoflagellates and diatom. Few oils such as the heavy oildrilled in the Cambrian reservoir from Tadong 2 well (TD2)correlated well with the extracts from the Cambrian. Theamazing similarity of the relative contents of these com-pounds between the marine oils produced in Tazhong andTabei uplifts and the extracts from the Upper Ordoviciansuggests that the Middle-Upper Ordovician is the very likelymain source for the marine oils.     

一种用于气体浓度监测的无线局域网络系统的设计

基于无线收发模块nRF24E1，设计了一种无线局域网络系统，实现点对多点H2S气体浓度的无线监测功能，阐述了系统硬件和软件的设计方法，通过构建合理的通信协议，有效地解决了节点间的通信寻址问题，保证了通信的可靠性；采用时分多路技术，提高了大容量系统的抗干扰性能，该系统可适用于区域内无线通信场合，具有良好的实用价值。     

环形区域上具有变号线性项的椭圆型方程的正径向解

讨论环形区域?={x∈RN|R1<|x|?a0(r);;f(u)超线性或次线性增长时;;该问题至少存在一个正径向解.     

单片机在注塑机压力设置技术中的应用

传统的注塑机压力设置采用机械拨码盘人工设置的方法,寿命短、可靠性差.本文采用单片机来改进传统注塑机的压力设置技术,可对近百种注塑产品的各道工序所需压力值进行预设、存储,并能使所设置数据在系统掉电后永久保持,提高了注塑机的生产效率和设备的可靠性.     

基于单片机控制的学生公寓用电系统的设计

随着高校现代化、智能化学生公寓的兴建,学生公寓用电智能管理控制系统得到了广泛应用,利用AT89S52单片机控制学生公寓用电的数据采集、处理、显示以及对异常用电的自动处理;通过RS485串口实现上位机与单片机之间的通信对学生公寓用电系统进行管理;采用电脑集中查询与LED自动显示相结合的查询方式,可方便地查询每个房间的用电量、剩余电量。目前该系统运行稳定、可靠,实现了学生公寓用电的智能化控制和管理。     

Effect of mutation in ribosomal protein on translation elongation

Translation accuracy, translation elongation rate and translation processivity are three important parameters for each elongation cycle. To study the role of ribosomal protein in translation elongation, these parameters were measured simultaneously for the first time in threeEscherichia coli T83 mutantsrpsL, rplX andrpmA. The results suggested that the mutants of ribosomal protein S12(rpsL) and ribosomal protein L24(rplX) decreased the processivity of ribosome while the mutant of ribosomal protein L27(rpmA) had little effect on the processivity;rplX mutant andrpmA mutant had higher accuracy; the elongation rate ofrplX mutant was faster than that of the wild type, whereas the elongation rate ofrpmA mutant was the same as that of the wild type.     

一个1.5V低相位噪声的高频率LC压控振荡器的设计

介绍了一种适用于DCC-1800系统的压控振荡器的设计,中心频率为3．6GHz．分析并比较了三种降低相位噪声的方法并进行了仿真验证,然后阐述了3．6GHz压控振荡器器件尺寸的优化分析．采用电感电容滤波技术降低相位噪声,在偏离中心频率600kHz处,仿真得到相位噪声为-117dBc／Hz,调谐范围达到26．7％．VCO电路在1．5V电压下工作,静态电流为6mA．     

无源LC传感器耦合线圈参数优化设计研究

通过对比实验,研究了无源LC传感器的相关电感线圈参数对耦合距离的影响,为传感器的参数优化设计提供指导。实验得出,线圈内径小的传感器耦合距离较远,但增加不明显;线圈外径越大的传感器的耦合距离越远,但是外径过大增强效果不明显;线宽1 mm的传感器相比线宽0.5 mm和0.3 mmm的传感器耦合距离增大较明显。由于线圈电阻的增加,匝数10以上的传感器并不能较大的增大耦合距离。圆形电感线圈传感器的耦合距离明显大于方形电感线圈的传感器,并且在相同耦合距离下圆形电感线圈的传感器的耦合效果要好于方形电感线圈的传感器。综上,在进行无源LC传感器电感线圈设计时,在一定的尺度范围内,线圈的内径要做小,外径和线宽要做大,匝数取10为宜,形状选取圆形。     

采用抗体包被金磁纳米微粒修饰电极的HIV p24/gp36安培联检芯片

研制了以聚碳酸酯为基底的双通道安培检测微流控免疫芯片,在其中分别集成了修饰有HIV核心抗原p24/gp36的单克隆一级抗体的纳米金修饰电极,并应用于人血清中p24和gp36抗原的同时分析.检测原理是:基于夹心免疫分析法,在电压驱动下,一次性加入含有p24和gp36样品及HRP酶标记的p24和gp36二级抗体溶液,与电极表面的一级抗体生成夹心免疫复合物;接着在体系中加入H2O2,以方波溶出伏安法检测免疫复合物上HRP催化H2O2的还原电流.在pH为6.2的磷酸缓冲液中,对HIV p24和gp36的检测时间均少于2 min,线性范围为0.5～400 μg/L,检测限为0.25 μg/L.该芯片集成了加样、分离和检测系统,检测时间短,灵敏度明显高于传统的酶联免疫吸附分析法,可应用于对艾滋病的旱期诊断和大范围筛查.