| Ⅰ-65增强柔红霉素抗癌活性的研究 |
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| 引用本文： | 赵丽.Ⅰ-65增强柔红霉素抗癌活性的研究[J].西北民族学院学报,1997(1). |
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| 作者姓名： | 赵丽 |
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| 作者单位： | 兰州医学院第一附属医院血液科 兰州，730000 |
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| 摘 要： | 采用体外细胞培养技术,观察了钙离子阻断剂3、6-=甲氨基]-=苯骈碘杂六环枸橼酸盐(I-65)单独和与柔红霉素(DNR)合用对L_(1210)细胞增殖的影响。结果:单独应用I-65时对细胞的增殖和集落形成抑制作用极小;与DNR合用,可显著增强DNR对细胞增殖的抑制作用。其ID_(50)为单用DNR的1/11。联合用药时细胞集落形成率较单用DNR(0.15μg/ml)下降14倍,证实I-65能显著增强DNR的抗癌活性,为广泛应用DNR,减轻心脏毒性,防止耐药提供新手段,为临床提供了一种新的抗癌药物增效剂。
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| 关 键 词： | I-65 柔红霉素 增强 抗癌活性 |
The Study on the I-65 Enhancing Antitumor Activity of Daunomycin (DNR) |
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| Zhao Li,Dept of Hematology,First Affiliated Hospital Lanzhou Medical College Lanzhou.The Study on the I-65 Enhancing Antitumor Activity of Daunomycin (DNR)[J].Journal of Northwest Minorities University(Natural Science ),1997(1). |
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| Authors: | Zhao Li Dept of Hematology First Affiliated Hospital Lanzhou Medical College Lanzhou |
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| Institution: | Zhao Li,Dept of Hematology,First Affiliated Hospital Lanzhou Medical College Lanzhou 730000 |
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| Abstract: | 3'6-dimethamidodibenzopyriodonium citrate (I-65) a new calcium cannel blocker for enhancing the cytotoxicity of daunomycin (DNR) in cultured L_(1210) leukemia cells in vitro. The ID_(50) of DNR to the cells is about 1.61vg/ml when the cells are treated with DNR alone. But when the cells are treated with DNR plus I-65 (5μg/ml), the ID_(50) of DNR is decreased to 1/11. In colony test. the survival ratio of the cells treated with DNR plus I-65 is decreased 14 times to the cells treated with DNR alone. So we suggest that I-65 can enhancing antitumor activity of DNR in vitro and may be used clinically as an antitumor drug enhancing DNR. |
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| Keywords: | I-65 DNR Enhance Antitumor Activity |
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