含铁赤泥还原分选机理探讨

本文着重从热力学和动力学上对广西三水铝土矿拜尔法赤泥还原焙烧机理进行分析和探讨.研究表明,在1150～1250℃左右进行还原焙烧,完成晶体结构重整,可使细粒分布的铁铝分离.这种新工艺对从矿石中固溶态的多金属分离与提取将是一项重大突破.     

形变和热处理条件对掺杂钨中钾泡弥散状态的影响

利用扫描电镜和透射电镜对采用不同形变和热处理工艺所生产的钨棒和钨丝进行了系统的研究,比较了钾泡的弥散状态和组织性能情况。研究结果表明,钾管的长宽比与变形程度之间有确定的关系,它随不同的变形阶段而变化。本文提出了钾管长宽比的关系式,计算结果与实验结果相符。研究还表明,旋锻加工再结晶退火后钨棒中钾泡的弥散状态,对于最终钨丝中钾泡的弥散状态及高温性能起决定的作用。     

共晶点左移理论在研制新型铸铁焊条时的应用

应用共晶点左移理论研制以奥氏体和铁素体为基体的两种类型铸铁冷焊焊条，具有较窄的白口区和较高的白口断续率，可以代替国家标准相应类型铸铁焊条。在研制中对共晶点左移理论的应用进一步作了分析     

Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex

A substantial decrease in the number of synapses occurs in the mammalian brain from the late postnatal period until the end of life. Although experience plays an important role in modifying synaptic connectivity, its effect on this nearly lifelong synapse loss remains unknown. Here we used transcranial two-photon microscopy to visualize postsynaptic dendritic spines in layer I of the barrel cortex in transgenic mice expressing yellow fluorescent protein. We show that in young adolescent mice, long-term sensory deprivation through whisker trimming prevents net spine loss by preferentially reducing the rate of ongoing spine elimination, not by increasing the rate of spine formation. This effect of deprivation diminishes as animals mature but still persists in adulthood. Restoring sensory experience after adolescent deprivation accelerates spine elimination. Similar to sensory manipulation, the rate of spine elimination decreases after chronic blockade of NMDA (N-methyl-D-aspartate) receptors with the antagonist MK801, and accelerates after drug withdrawal. These studies of spine dynamics in the primary somatosensory cortex suggest that experience plays an important role in the net loss of synapses over most of an animal's lifespan, particularly during adolescence.     

二级对角隐Runge-Kutta方法的B-收敛性

本文讨论了二级对角隐 Runge-Kutta 方法的 B-相容,B-稳定及 B-收敛性,导出了方法的1阶最优 B-收敛性,从而改进和推广了朱方生1988年的结果.本文讨论 B-相容,B-稳定性所用方法不同于 Dekker & Verwer 1984年的方法,所得误差估计较前更为精确,其中 B-稳定性的讨论也推广和修正了 Burrage & Butcher 1979年的结果.     

广东省入境旅游业发展差异时空演变研究

以广东省21地市为研究对象,基于1999—2009年数据,利用标准差、变异系数、集中指数、重心法、灰色关联分析等方法分析了广东省白1999年以来入境旅游发展差异的时空演变情况．结果表明：1）广东省入境旅游发展的绝对差异在不断扩大,相对差异呈缩小趋势,仇变幅较小,且入境旅游发展差异主要表现为珠三角内部地市之间的差异;2）广东省入境旅游发展差异的空间极化效应明显,发展极不平衡,集中度高,在空间上形成了明显的“双核四区（广州、深圳双核,珠三角、东翼、西翼、山区四区）”格局;3）灰色关联分析方法定量地揭示了广东省入境旅游发展地市差异与旅游资源分布的地市差异关联度不大,经济发展水平、区位条件、交通条件等是影响广东省各地市入境旅游业发展的主要因素．     

山东省经济社会协调发展格局及对策研究

经济社会协调发展是实现可持续发展的前提和基础,对于山东省和谐社会的构建意义重大．笔者根据山东省2010年17地市相关数据,选取经济和社会两个系统共30项基本指标,建立了一个多层次系统的评价模型,定量评价了山东省17城市的经济与社会发展的协调性,得出以下结论：山东省经济社会协调水平较低,在空间上存在由东向西明显的梯度性格局,社会发展水平落后导致了山东省17城市经济社会协调发展度偏低．最后从协调发展类型的角度提出山东省经济社会协调发展的相关对策建议．     

Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo

Many lines of evidence suggest that memory in the mammalian brain is stored with distinct spatiotemporal patterns. Despite recent progresses in identifying neuronal populations involved in memory coding, the synapse-level mechanism is still poorly understood. Computational models and electrophysiological data have shown that functional clustering of synapses along dendritic branches leads to nonlinear summation of synaptic inputs and greatly expands the computing power of a neural network. However, whether neighbouring synapses are involved in encoding similar memory and how task-specific cortical networks develop during learning remain elusive. Using transcranial two-photon microscopy, we followed apical dendrites of layer 5 pyramidal neurons in the motor cortex while mice practised novel forelimb skills. Here we show that a third of new dendritic spines (postsynaptic structures of most excitatory synapses) formed during the acquisition phase of learning emerge in clusters, and that most such clusters are neighbouring spine pairs. These clustered new spines are more likely to persist throughout prolonged learning sessions, and even long after training stops, than non-clustered counterparts. Moreover, formation of new spine clusters requires repetition of the same motor task, and the emergence of succedent new spine(s) accompanies the strengthening of the first new spine in the cluster. We also show that under control conditions new spines appear to avoid existing stable spines, rather than being uniformly added along dendrites. However, succedent new spines in clusters overcome such a spatial constraint and form in close vicinity to neighbouring stable spines. Our findings suggest that clustering of new synapses along dendrites is induced by repetitive activation of the cortical circuitry during learning, providing a structural basis for spatial coding of motor memory in the mammalian brain.     

CXCR7对HeLa细胞增殖、粘附和侵袭能力的影响

基质细胞衍生因子-1(SDF-1)在肿瘤侵袭、转移过程中起着重要的调控作用.此前认为SDF-1是通过其唯一受体CXCR4来起作用.近年来发现SDF-1还有另一作用受体——CXCR7,SDF-1/CXCR7在部分肿瘤侵袭转移过程中起重要作用,但其在宫颈癌HeLa细胞中的作用目前尚未明确.通过Western blotting检测HeLa细胞中CXCR4和CXCR7的表达,阻断CXCR4或CXCR7后,通过MTT法评价细胞增殖能力,细胞粘附实验评价细胞粘附能力,Transwell实验评价细胞侵袭能力.结果表明,CXCR4和CXCR7在HeLa细胞中表达.阻断CXCR4或CXCR7后,SDF-1诱导的HeLa细胞增殖、侵袭和与内皮细胞的粘附能力均被阻断.结果提示CXCR7在SDF-1诱导HeLa细胞增殖、侵袭和与内皮细胞的粘附过程中起着重要作用,将有望成为治疗宫颈癌转移的新靶点.     

聚晶金刚石拉丝模卧式超声加工运动轨迹的计算机仿真

分析了聚晶金刚石拉丝模卧式超声加工机床的运动关系,建立了工具和拉丝模之间的运动轨迹方程;采用计算机仿真技术对工具和拉丝模之间的运动轨迹进行研究,在仿真基础上对加工参数进行优化.结果表明,加工运动轨迹方程是以卡盘电机转速(N),偏心轮电机转速(F)和杠杆旋转中心位置(a)为参数的函数.当N与F之间存在关系N=zF/n(z,n为正整数)时,加工轨迹会出现严重的不均匀现象.当n值一定时,z越小,加工轨迹不均匀现象越明显.计算机仿真技术可以对聚晶金刚石拉丝模卧式超声加工的运动轨迹进行优化,并为机械结构的进一步优化提供有效指导.