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排序方式: 共有125条查询结果,搜索用时 15 毫秒
91.
92.
14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome 总被引:4,自引:0,他引:4
Toyo-oka K Shionoya A Gambello MJ Cardoso C Leventer R Ward HL Ayala R Tsai LH Dobyns W Ledbetter D Hirotsune S Wynshaw-Boris A 《Nature genetics》2003,34(3):274-285
Heterozygous deletions of 17p13.3 result in the human neuronal migration disorders isolated lissencephaly sequence (ILS) and the more severe Miller-Dieker syndrome (MDS). Mutations in PAFAH1B1 (the gene encoding LIS1) are responsible for ILS and contribute to MDS, but the genetic causes of the greater severity of MDS are unknown. Here, we show that the gene encoding 14-3-3epsilon (YWHAE), one of a family of ubiquitous phosphoserine/threonine-binding proteins, is always deleted in individuals with MDS. Mice deficient in Ywhae have defects in brain development and neuronal migration, similar to defects observed in mice heterozygous with respect to Pafah1b1. Mice heterozygous with respect to both genes have more severe migration defects than single heterozygotes. 14-3-3epsilon binds to CDK5/p35-phosphorylated NUDEL and this binding maintains NUDEL phosphorylation. Similar to LIS1, deficiency of 14-3-3epsilon results in mislocalization of NUDEL and LIS1, consistent with reduction of cytoplasmic dynein function. These results establish a crucial role for 14-3-3epsilon in neuronal development by sustaining the effects of CDK5 phosphorylation and provide a molecular explanation for the differences in severity of human neuronal migration defects with 17p13.3 deletions. 相似文献
93.
Quasicrystals have long-range order with symmetries that are incompatible with periodicity, and are often described with reference to a higher-dimensional analogue of a periodic lattice. Within the context of this 'hyperspace' crystallography, lattice dynamics of quasicrystals can be described by a combination of lattice vibrations and atomic fluctuations--phonons and phasons. However, it is difficult to see localized fluctuations in a real-space quasicrystal structure, and so the nature of phason-related fluctuations and their contribution to thermodynamic stability are still not fully understood. Here we use atomic-resolution annular dark-field scanning transmission electron microscopy to map directly the change in thermal diffuse scattering intensity distribution in the quasicrystal, through in situ high-temperature observation of decagonal Al72Ni20Co8. We find that, at 1,100 K, a local anomaly of atomic vibrations becomes significant at specific atomic sites in the structure. The distribution of these localized vibrations is not random but well-correlated, with a quasiperiodic length scale of 2 nm. We are able to explain this feature by an anomalous temperature (Debye-Waller) factor for the Al atoms that sit at the phason-related sites defined within the framework of hyperspace crystallography. The present results therefore provide a direct observation of local thermal vibration anomalies in a solid. 相似文献
94.
95.
M. T. Lin W. Y. Chia C. T. Tsai T. H. Yin 《Cellular and molecular life sciences : CMLS》1978,34(6):756-757
Summary Intraventricular administration of 6-OHDA or 5,6-DHT suppressed food intake, whereas their effect on active avoidance produced a suppression with the former and an enhancement with the latter. The increased water intake was specifically associated with 5,6-DHT treatment in rats.This work supported by grants from the National Science Council (Republic of China), J. Aron Charitable Foundation (USA) and John B. Pierce Foundation (USA). The authors are grateful to Drs C.Y. Chai and H. H. Lu for their support and advice. 相似文献
96.
Actively transcribed genes are associated with the nuclear matrix 总被引:13,自引:0,他引:13
97.
应用群分解BHMO程序,研究了含S_2的固氮酶活性中心模型和N_2的络合活化模式.结果表明,在结构参数优化的情况下,平躺式络合与微斜插入式络合的键能差别不大(前者仅高约1ev),实际的络合方式很可能是直插式的或微斜插入式的,这样在加进1个H或两个H后,μ_3-H_2就转化为端基络合在Mo上的-N=NH或=N-NH_2。对奇数电子体系,由于其LUMO和NHOMO之间能级差别小,如对称性相同,易于产生d—d跃迁,从而为S=3/2的实验事实提供了可能的解释. 相似文献
98.
发现掺有碱土金属组份的ZrO2样品形成AZrO3相,其对甲烷氧化偶联反应显示出相当好的催化活性和选择性(其中A=Ca,Sr,Ba,尤以Ba为佳).大量BaCO3相的存在有利于进一步提高催化剂的选择性;对于90mol%Ba-ZrO2催化剂在750℃,60000ml·g-1·h-1,CH4:O2:N2=3.8:1.0:9.0(摩尔比)的条件下,C2烃选择性为56.9%,C2烃得率达17.2%.讨论了BaCO3对几种催化剂的促进作用. 相似文献
99.
考察碱土金属氟化物/三氧化二钆在甲烷氧化偶联反应中的催化性能.发现在Gd_2O_3中添加碱土金属氟化物,C_2选择性和收率都有明显提高。当Gd_2O_3摩尔含量相同时,催化性能按Ca-Sr-Ba顺序递增,在80%BaF_2/Gd_2O_3催化剂上C_2选择性和收率分别达59.5%和18.7%.XRD分析结果表明,在含氟催化剂中出现了四方Gd_4O_3F_6新相,其结构与立方CaF_2,SrF_2和BaF_2相似.可能有利于物相之间的匹配及载流子传递.XPS测试发现,催化剂表面上存在着(或O ̄-)物种.与Gd_2O_3相比,在含氟的催化剂中,O_1s结合能较高,表明该吸附氧物种所带电荷较少,对提高C_2选择性有利。 相似文献
100.
对用共沉淀法制备并经氢预还原活化的三组份 Cu-ZnO-Al_2O_3 和四组份Cu-ZnO-Al_2O_3-M_2O_3(M=Sc~(3+)、Cr~(3+)或In~(3+))铜基甲醇合成催化剂进行 XPS,XPS-Augcr,TPD谱表征及CO吸附量测定,研究铜基甲醇合成催化剂活性表面铜的化学态。根据原子价补偿原理及本实验结果,在温和还原条件下,催化剂活性表面存在少量Cu~+,它是 CO、H_2 的吸附活性位。 相似文献