A Survey of the Use of the Discrete-event Simulation in Manufacturing Industry

In this work, a survey of companies has been produc ed from a questionnaire and in-depth inter-views. The aimof the paper is to give a current view of the use of DES (Discrete- Event Simulation) in the indust ry. The companies have been selected in a wide range in e.g. size, capital turno ver and employees. The survey was restricted to Sweden, although the results may be applicable to other countries with similar industrial structure. Some of the companies investigated are also multinational with branc...     

Family I.3 lipase: bacterial lipases secreted by the type I secretion system

Based on the classification of bacterial lipolytic enzymes, family I.3 lipase is a member of the large group of Gram-negative bacterial true lipases. This lipase family is distinguished from other families not only by the amino acid sequence, but also by the secretion mechanism. Lipases of family I.3 are secreted via the well-known type I secretion system. Like most of proteins secreted via this system, family I.3 lipases are composed of two domains with distinct yet related functions. Recent years have seen an increasing amount of research on this lipase family, in terms of isolation, secretion mechanism, as well as biochemical and biophysical studies. This review describes our current knowledge on the structure-function relationships of family I.3 lipase, with an emphasis on its secretion mechanism. Received 18 April 2006; received after revision 3 July 2006; accepted 24 August 2006     

Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration

Age-related macular degeneration (AMD) is a common, late-onset disease with seemingly typical complexity: recurrence ratios for siblings of an affected individual are three- to sixfold higher than in the general population, and family-based analysis has resulted in only modestly significant evidence for linkage. In a case-control study drawn from a US-based population of European descent, we have identified a previously unrecognized common, noncoding variant in CFH, the gene encoding complement factor H, that substantially increases the influence of this locus on AMD, and we have strongly replicated the associations of four other previously reported common alleles in three genes (P values ranging from 10(-6) to 10(-70)). Despite excellent power to detect epistasis, we observed purely additive accumulation of risk from alleles at these genes. We found no differences in association of these loci with major phenotypic categories of advanced AMD. Genotypes at these five common SNPs define a broad spectrum of interindividual disease risk and explain about half of the classical sibling risk of AMD in our study population.     

气候变迁、适应能力及其发展

政府间小组委员会(IPCC)提供的第三次有关气候变化评估报告，强有力的说明了由人类诱发的气候变迁正在发生，而且世界上所有的国家都将会受到影响。     

宽能带隙电子器件

硅集成电路和数据存贮是两种最成功的技术，目前，这两种技术继续以高速度发展。在集成电路技术中，按照摩尔定律，一块芯片上的晶体管数目每隔18个月就会翻一翻。而对于磁盘驱动技术，自1991年起磁头的总体位密度以每年60％至100％的速率增加。集成电路是通过对半导体应用电场控制载流子流动来工作的，因此关键的参数是电子或空穴上的电荷。而在磁性数据存贮中关键的参数是电子的自旋。     

应用量子力学

量子力学是当前物理学及其相关科学的重要科学分支，也是当前许多新科学技术中的重要应用的基础。本书包含了现代新科学技术工程师所需要的量子力学方面的新材料，如研究和了解原子核、原子、分子和固体材料，以及激光器和其他量子光学器件所需要的科学资料等。     

蝈蝈的冬夜春歌

我真不知道它有多么充沛的精力,在午夜三更时刻,冬天的蝈蝈在我的书房里,一口气吟唱了八百多声。那是春节午夜守岁时发生的,当北京的大钟报告鸡后来临的时候,书斋里留下它吟唱新春昂扬而欢快的歌声。说来像是一个童话:初夏时我曾养过两只蝈蝈,到了冬至后的11月18日,两只蝈蝈像是有“虽非同时生,但愿同时死”的情约那般,一块静卧于蝈蝈笼子中,结束了它们的歌唱生涯。死前它们还有一个相同的生命特征,像人走进天国之前都要衰老一样,先是哑然失声,后又掉了双腿,最后才蜷曲着身子在蝈蝈笼子中安息了。不知为了什么,在那几天我曾有失去两个小小挚…     

非线性极限点和极限圆问题

1910年H．weyl首次提出极限点和极限圆问题，导致了上世纪非线性微分方程渐近分析研究的一些新进展。本书是关于这个研究的专著，对问题的产生、发展、扩充及主要结果和研究趋势等方面进行了论述。