用快速白光辐照生成钨硅化物

报导了用快速白光辐照、通过薄膜反应在GaAs衬底上生成单一化学相的硅化物W_5Si_3,对样品的结构方式和硅供应量对钨硅化物生成相的影响进行了讨论。     

一类两参数 Wiener 过程

本文讨论一类形为 W(x,n)的两参数 Wiener 过程,及其与单参数Wiener 过程相类似的连续模的几种形式.对于[2]中关于增量的与[4]中关于增量的的讨论,分别给出关于增量的与的相应结果。     

Historical development of the Chinese remainder theorem

Communicated by C. Truesdell     

用双波长分光光度法研究钙、镁与酸性铬蓝K的络合反应

用双波长分光光度法测定了钙、镁与酸性铬蓝K 所形成的络合物的组成比;用数学微分模型法测得了络合物的组成和稳定常数。     

共轭梯度法应用于解电磁场的散射和辐射问题

本文将共轭梯度法(CGM)应用于电大尺度(几个波长以))的散射和辐射问题的矩量法中.在二维、TM 情况下,对于用列表法有效地实现节约内贮作了比较详细的讨论;通过多个典型例子加以说明,并和传统方法进行了比较,归纳出应用CGM 的长处和存在的问题.在此基础上,将CGM 应用于解决散射体内部谐振对外影响的边界扩展中,并通过实例加以说明.     

光测综合应力模型实验研究

本文提出一种新的高容重、低弹模的实验材料，采用埋置在模型内的高灵敏度、低弹模的光测元件观测本身的应力。利用模型材料自身的重力可以产生与原型相似的累积的构筑荷重，同一个模型可以重复用于多种荷载工况。这种新的实验方法为研究由水压、自重等等荷载引起的综合应力提供有利的条件，并将提高实验效率。本文还给出了一个应用实例。     

"器官投影说"的现代解说

技术哲学创始人恩斯特·卡普于1877年出版的<技术哲学纲要>一书,提出了"器官投影说",即人类在制造工具和其他物体时通常使它们与人体有结构上和(或)功能上的相似性.卡普运用"器官投影说"解释了当时已知的各种技术现象.在技术迅猛发展的今天,结合现代高新技术对"器官投影说"进行哲学反思,仍有重要意义.     

Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway

Enhanced cell migration is one of the underlying mechanisms in cancer invasion and metastasis. Therefore, inhibition of cell migration is considered to be an effective strategy for prevention of cancer metastasis. We found that emodin (3-methyl-1,6,8-trihydroxyanthraquinone), an active component from the rhizome of Rheum palmatum, significantly inhibited epidermal growth factor (EGF)- induced migration in various human cancer cell lines. In the search for the underlying molecular mechanisms, we demonstrated that phosphatidylinositol 3-kinase (PI3K) serves as the molecular target for emodin. In addition, emodin markedly suppressed EGF-induced activation of Cdc42 and Rac1 and the corresponding cytoskeleton changes. Moreover, emodin, but not LY294002, was able to block cell migration in cells transfected with constitutively active (CA)-Cdc42 and CA-Rac1 by interference with the formation of Cdc42/Rac1 and the p21-activated kinase complex. Taken together, data from this study suggest that emodin inhibits human cancer cell migration by suppressing the PI3K-Cdc42/Rac1 signaling pathway.Received 7 February 2005; received after revision 11 March 2005; accepted 18 March 2005     

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

Signalling by Wnt proteins (Wingless in Drosophila) has diverse roles during embryonic development and in adults, and is implicated in human diseases, including cancer. LDL-receptor-related proteins 5 and 6 (LRP5 and LRP6; Arrow in Drosophila) are key receptors required for transmission of Wnt/beta-catenin signalling in metazoa. Although the role of these receptors in Wnt signalling is well established, their coupling with the cytoplasmic signalling apparatus remains poorly defined. Using a protein modification screen for regulators of LRP6, we describe the identification of Xenopus Casein kinase 1 gamma (CK1gamma), a membrane-bound member of the CK1 family. Gain-of-function and loss-of-function experiments show that CK1gamma is both necessary and sufficient to transduce LRP6 signalling in vertebrates and Drosophila cells. In Xenopus embryos, CK1gamma is required during anterio-posterior patterning to promote posteriorizing Wnt/beta-catenin signalling. CK1gamma is associated with LRP6, which has multiple, modular CK1 phosphorylation sites. Wnt treatment induces the rapid CK1gamma-mediated phosphorylation of these sites within LRP6, which, in turn, promotes the recruitment of the scaffold protein Axin. Our results reveal an evolutionarily conserved mechanism that couples Wnt receptor activation to the cytoplasmic signal transduction apparatus.     

浅谈程序设计语言课程教学方法

程序设计语言课程的一个最基本目的是:使学生既掌握程序设计语言的语法知识、编程技术和基本算法,又掌握程序设计的思想和方法,更具备利用计算机求解实际问题的能力,能灵活运用程序设计语言进行程序设计。现在很多高校都为学生开设了程序设计语言课程,但不论是计算机专业还是其他专业的学生在学习本类课程时,一般都处于计算机程序设计的初学者阶段,在教学过程中较难的是如何激发学生的兴趣、引导学生突破传统的思维方式,进而使学生建立起计算机世界的语言描述和解决问题的模式。为此,探究了一套程序设计语言课程的教学方法,即以学生为主体,教学与实验相伴授课,并扩展传统的实验课为“小课题实验讨论课”,同时根据学生情况分级教学,最终让学生兴奋、愉悦、主动、独立地解决实际问题,并作出科学的总结。