大学生勤工助学体验性学习实践模式探索

以北京联合大学的大学生勤工助学体验性学习实践为例,通过课题研究,探讨了适用于高校大学生勤工助学体验性学习实践的模式。     

变频调速泵在滤池反冲洗中的节能效果

为了响应现在我国大力倡导的节能的政策,决定将滤池反冲洗中所用的水泵进行改造,把原来的高位水箱反冲洗系统改为利用变频技术.采用水泵直接反冲洗来达到节能的目的,计算了滤池反冲洗采用变频调速泵所节约的电耗,并对其节能效果进行了分析.     

读宋诗辨昭君、玉环之宋代际遇

王昭君、杨玉环及其关联的人和事,是古代文人经常选用的题材和载体,尤其是在国势相对衰微、女性观念尤重"妇德"及文学"尚古"之风盛行的宋代。文章即从解读王安石、欧阳修、苏轼、陆游及杜甫、李商隐、罗隐等相关诗作入手,辨析宋人有别于唐人的立场和态度及产生的原因,从而证明昭君、玉环在宋代虽际遇不同,但在文学功用上却异中有同、殊途同归。     

“二三结合”开发模式渗流特征研究

L油田B区块开展"二三结合"实验区,"二三结合"开发模式渗流特征对区块的合理高效开发具有重要意义。为了明确其渗流特征,利用油藏数值模拟软件Eclipse建立代表意义的油藏数值模型,研究区块"二三结合"开发模式下原射孔层和补孔层的渗流特征,分析了"二三结合"开发模式下,不同开发阶段综合含水率、采出程度、井底压力、地层压力及含水饱和度的变化特征。研究表明,"二三结合"开发模式先通过水驱开发挖潜原射孔层剩余油,提高厚油层顶部剩余油的采出程度,再通过聚合物驱进一步提高开发效果,通过水驱与聚驱的综合作用,最终得到较好的开发效果。     

Learning Multi Labels from Single Label——An Extreme Weak Label Learning Algorithm

This paper presents a novel algorithm for an extreme form of weak label learning, in which only one of all relevant labels is given for each training sample. Using genetic algorithm, all of the labels in the training set are optimally divided into several non-overlapping groups to maximize the label distinguishability in every group. Multiple classifiers are trained separately and ensembled for label predictions. Experimental results show significant improvement over previous weak label learning algorithms.     

基于改进多目标遗传算法的连铸二冷过程优化

采用一种改进的多目标遗传算法对二冷工艺进行优化.改进的多目标遗传算法应用概率法选取选择算子，根据适应度值来动态计算交叉和变异概率，能够得到更好的全局最优解，提高算法精度和整体性能.在基于凝固传热模型的二冷优化过程中，采用变间距差分法离散求解传热方程，对比粒子群算法、多目标遗传算法，改进的多目标遗传算法搜索效率高，得到的价值函数最小.在实际生产中，采用优化后的二冷工艺，使得总用水量减少约10%，提高了铸坯质量，达到了节能降耗的要求.     

基于曼哈顿距离构建非参数Q矩阵修正方法

将被试得分、理想反应距离和被试得分异常原理相结合,并加入属性计分下的被试得分特性,开发了用于多级评分情境下属性计分曼哈顿距离法(SA-MD),在不同条件下验证了SA-MD的稳定性和适宜性.通过模拟研究和实证研究表明:(i)从逻辑推导出SA-MD用于多级评分情境下Q矩阵修正更合理;(ii)在多种条件中,SA-MD 均有较优的修正效果,适用范围更广,稳定性更高;(iii)当小样本测验进行Q矩阵修正时,使用SA-MD方法可获得更优的效果.     

工程实践中的体系与系统

 介绍了国际上通行的体系概念，通过实例阐述了常见的体系类型，从多个维度描述了系统与体系的区别，根据实践总结，提出体系与系统的核心界定准则，并结合工程实践进行了详细描述。     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

彩虹黑弦的热力学性质

双重相对论(DSR)是描述平直时空中的量子引力的一个有效模型.当试图将该模型纳入到弯曲时空中考虑时,一种被称为"彩虹引力"的理论可帮助实现这一推广,此时背景时空依赖于探测粒子的能量.事实上受粒子能量影响的度规的形式依赖于正交系的选取.本文主要考虑了自由落体参考系下的彩虹静态柱对称黑洞(彩虹黑弦).得到了取一阶近似的彩虹黑弦的霍金温度和熵,这种修正来源于考虑的彩虹引力效应.