曲线连续箱梁桥的偏心距及其对支座反力的影响

讨论圆弧曲线箱梁桥的偏心距及其对支座反力的影响.结果表明:内支座采用单支座布置的曲线连续箱梁桥可以通过改变支座的偏心距来调整支座的反力差.不同的支座布置形式合适的偏心距不同,并随着圆心角的增大而增大,边跨端部布置固定支座时偏心距较大,中间内支座采用墩梁固结时偏心距较小.     

三维帧间配准预测的V-PCC改进算法

针对视频点云压缩(video-based point cloud compression,V-PCC)把点云序列分解成2D的非规则图像块(patch)进行编码,破坏点云连续性,不利于后续帧间预测的问题,设计一种三维配准帧间预测结合V-PCC帧间预测的改进算法.首先,为了提高点云配准的有效性,设计一种基于运动一致性的二叉...     

混凝土泵车输料管流构耦合振动研究

混凝土泵车在浇注过程中,输料管振动和混凝土流动是典型的流构耦合现象.建立了输料管和混凝土的耦合运动微分方程;通过无量纲化、离散化得到了在不同流速和不同压力下进行混凝土输送时管道的固有频率曲线.随着输送压力的提高,一阶和二阶固有频率降低;而随着输送速度的提高,固有频率则逐渐升高.在确定压力和流速之后,可以避免浇注过程工作在共振频率范围之内,从而减少对臂架的疲劳破坏.为混凝土浇注过程压力、输送速度及混凝土泵的工作频率选择提供了依据.     

关联规则算法的电信网络告警应用

为提高网络告警数据的处理效率,迅速找出故障根源,以保证整个电信网络的正常运行。针对告警数据的特点对传统的关联规则算法进行了相应的改进,提供了优先剪枝策略,避免了生成没有意义的频繁项集;k-1-项集通过连接操作生成k项集,避免了反复扫描数据库所带来的压力。结果表明,改进算法提高了挖掘效率,达到快速诊断网络故障的目的。     

适应气候变化技术识别标准研究

 适应气候变化是现阶段应对气候变化行动的重要举措。适应气候变化技术的识别标准是编制适应气候变化清单的基础, 是适应气候变化方法学的重要组成部分。本研究通过对气候变化及其影响进行分析, 明确人类所面对的气候变化问题的内涵;结合适应技术定义, 确立适应气候变化技术核心识别标准是气候变化问题的针对性, 其关键在于将技术的适应方面与常规方面区分开来。另一方面, 对比分析适应技术与减缓技术, 明确有效区分技术的减缓效果与适应效果是适应气候变化技术识别的重要标准。依托识别标准, 不但可以对不同领域、不同地域已有的适应技术进行识别筛选, 也可为未来适应气候变化技术研发提供指导, 为适应气候变化技术体系构建奠定基础。     

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.     

Regulation of self-renewal and differentiation by the intestinal stem cell niche

The gastrointestinal epithelium is a highly organised tissue that is constantly being renewed. In order to maintain homeostasis, the balance between intestinal stem cell (ISC) self-renewal and differentiation must be carefully regulated. In this review, we describe how the intestinal stem cell niche provides a unique environment to regulate self-renewal and differentiation of ISCs. It has traditionally been believed that the mesenchymal myofibroblasts play an important role in the crosstalk between ISCs and the niche. However, recent evidence in Drosophila and in vertebrates suggests that epithelial cells also contribute to the niche. We discuss the multiple signalling pathways that are utilised to regulate stemness within the niche, including members of the Wnt, BMP and Hedgehog pathways, and how aberrations in these signals lead to disruption of the normal crypt–villus axis. Finally, we also discuss how CDX1 and inhibition of the Notch pathway are important in specifying enterocyte and goblet cell differentiation respectively.     

圆柱与圆锥轴线正交时特殊点的探讨

本文讨论圆柱面与圆锥面轴线正交时，非转向线上相贯线的特殊，点的定位与两回转面主要参数之间的关系。     

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

Bacterial infection of the mammalian bloodstream can lead to overwhelming sepsis, a potentially fatal syndrome of irreversible cardiovascular collapse (shock) and critical organ failure. Cachectin, also known as tumour necrosis factor, is a macrophage-derived peptide hormone released in response to bacterial lipopolysaccharide, and it has been implicated as a principal mediator of endotoxic shock, although its function in bacterial sepsis is not known. Anaesthetized baboons were passively immunized against endogenous cachectin and subsequently infused with an LD100 dose of live Escherichia coli. Control animals (not immunized against cachectin) developed hypotension followed by lethal renal and pulmonary failure. Neutralizing monoclonal anti-cachectin antibody fragments (F(ab')2) administered to baboons only one hour before bacterial challenge protected against shock, but did not prevent critical organ failure. Complete protection against shock, vital organ dysfunction, persistent stress hormone release and death was conferred by administration of antibodies 2 h before bacterial infusion. These results indicate that cachectin is a mediator of fatal bacteraemic shock, and suggest that antibodies against cachectin offer a potential therapy of life-threatening infection.